Genetic Bypass by Amy Yasko

[Guest guest]

This is a book you get when you order the test kit from testing4health

which is as far as I know, essentially her company...

I have begun the book and just like her lectures, I am really enjoying

it. It's at a very sophisticated level. Rich, you should probably read

it if you haven't before.

Even the beginning jibes so nicely with what I believe. She points out

that in the future we will not be looking at single gene mutations,

but multiple possibilities for mutations in a PATHWAY, that can derail

that pathway. She is not alone in this view, this is the view that is

'seducing' more and more good scientists who are starting to do good

work, esp. epidemiological.

She then points out that the methylation pathway is so important to

look at because it affects immune, neuro, etc. Although I'm of the

belief that immune endocrine and neuro are just one big system that we

think of differently because of its different facets.

I'll report more on this later but for the scientifically minded, it's

good stuff. And, I know DAN folks don't 'respect' her or Gordons

approach but the level of this book shows a deep understanding of the

issues involved. This level of understanding could not have been

achieved without great intelligence and application. I tend to trust

her, therefore.

[Guest guest]

Hi All,

I am also waiting for my " Yasko " genetic test results and agree " Genetic

Bypass " is excellent.

Another great book by Amy Yasko N.D. and Garry Gordon MD is " The Puzzle of

Autism: Putting It All Together " This book is another step further in

explaining the brain inflammation(which really relates to me) and excitotoxins,

RNA viruses, and genetic mutations, etc.. It helps with treatments.

By the way since lowering glutamate, glycine, and citrates out of my diet my

headaches, face tingling and numbness, and eye pain and flshing are gone. I

think it was inflammation. These books help explain this to me . Methyl B12 has

helped heal my nerves.

Things are turning around even more now with adding Yasko to the DAN! program

.. . . I believe it will be a mix of both but I am on the " Yasko Bandwagon " for

now. I have back off on DAN! mostly for awhile till I get the Yasko genetic

testing back.

I'll keep you all posted . . . but these books are worth reading.

I was told she has a 5 year waiting list . . . she has to be doing something

right!

Best to all,

Sue T

jill1313 <jenbooks13@...> wrote:

This is a book you get when you order the test kit from testing4health

which is as far as I know, essentially her company...

I have begun the book and just like her lectures, I am really enjoying

it. It's at a very sophisticated level. Rich, you should probably read

it if you haven't before.

Even the beginning jibes so nicely with what I believe. She points out

that in the future we will not be looking at single gene mutations,

but multiple possibilities for mutations in a PATHWAY, that can derail

that pathway. She is not alone in this view, this is the view that is

'seducing' more and more good scientists who are starting to do good

work, esp. epidemiological.

She then points out that the methylation pathway is so important to

look at because it affects immune, neuro, etc. Although I'm of the

belief that immune endocrine and neuro are just one big system that we

think of differently because of its different facets.

I'll report more on this later but for the scientifically minded, it's

good stuff. And, I know DAN folks don't 'respect' her or Gordons

approach but the level of this book shows a deep understanding of the

issues involved. This level of understanding could not have been

achieved without great intelligence and application. I tend to trust

her, therefore.

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Hi, Sue and Jill.

Sue: It's great to hear that those symptoms are gone!

Jill: I'll have to get that book!

Rich

> This is a book you get when you order the test kit from

testing4health

> which is as far as I know, essentially her company...

> I have begun the book and just like her lectures, I am really

enjoying

> it. It's at a very sophisticated level. Rich, you should probably

read

> it if you haven't before.

>

> Even the beginning jibes so nicely with what I believe. She points

out

> that in the future we will not be looking at single gene mutations,

> but multiple possibilities for mutations in a PATHWAY, that can

derail

> that pathway. She is not alone in this view, this is the view that

is

> 'seducing' more and more good scientists who are starting to do

good

> work, esp. epidemiological.

>

> She then points out that the methylation pathway is so important to

> look at because it affects immune, neuro, etc. Although I'm of the

> belief that immune endocrine and neuro are just one big system

that we

> think of differently because of its different facets.

>

> I'll report more on this later but for the scientifically minded,

it's

> good stuff. And, I know DAN folks don't 'respect' her or Gordons

> approach but the level of this book shows a deep understanding of

the

> issues involved. This level of understanding could not have been

> achieved without great intelligence and application. I tend to

trust

> her, therefore.

>

>

>

>

>

>

> This list is intended for patients to share personal experiences

with each other, not to give medical advice. If you are interested

in any treatment discussed here, please consult your doctor.

>

>

>

>

[Guest guest]

> > Even the beginning jibes so nicely with what I believe. She

points out that in the future we will not be looking at single gene

mutations, but multiple possibilities for mutations in a PATHWAY,

that can derail that pathway. She is not alone in this view, this is

the view that is 'seducing' more and more good scientists who are

starting to do good work, esp. epidemiological.

> >

I wonder what ever happened to the Voyager RNA? -

---------------------------------------------------------------------

A DIAGNOSTIC MARKER FOR CFS?

THE POKER GAME GOING ON IN OUR GENES

This article, by Carol Sieverling, is based on a conversation with

Dr. Cheney taped in October 1999. Dr. Cheney has reviewed this

article and it is shared with his permission. Feel free to repost

and reprint.

---------------------------------------------------------------------

-----------

Dr. Cheney read a newly published study this summer and

glimpsed a possible diagnostic marker for CFS. Test subjects

included three Gulf War Veterans, seven healthy control subjects,

and two people with active polio-virus. Researchers probed their

blood for both RNA and DNA. They found thousands of different sized

RNA segments floating around in the serum of veterans, a small

amount in the polio subjects, and none in the healthy controls. The

researchers called this voyager RNA since it travels around in the

blood outside of the cells.

This finding in the veterans is highly unusual on four counts.

They had RNA segments in their blood, they had a lot of RNA segments

in their blood, they had a lot of aberrant RNA segments in their

blood, and they all the same aberrant RNA segments in their blood.

The segments from the three veterans varied by less than 1%.

The researchers isolated the aberrant sequence and examined it

in detail. They began recognizing certain pieces, which they

realized all came from part of chromosome 22. It appeared that a

section of chromosome 22 had been sliced up, rearranged, pieces from

somewhere else inserted, and the whole thing reconnected.

Amazingly, a section of chromosome 22 appears to be altered, and

it's altered the same way in all three veterans!

Since these veterans had symptoms identical to CFS, Dr. Cheney

began testing CFS patients and almost all had this same aberrant RNA

segment. This strongly suggests that the veterans and the CFS

patients have the same illness, and that the aberrant segment of RNA

is very likely a diagnostic marker. Dr. Cheney suspects that this

marker only appears well into the illness, and will not be found

close to onset. He also believes that the amount of aberrant RNA in

the blood serum may correlate with illness severity.

Why would patients with CFS and GWS have an aberrant piece of

RNA, and why would they all happen to have the same one? Dr. Cheney

uses a wonderful analogy to explain it - a poker game. When we're

faced with an extreme threat to our health, our body plays poker

with its DNA in order to find something that will help. Our body is

breaking some of our DNA up into cards and shuffling them to see if

it can deal a winning hand.

There are three possibilities when dealing out poker hands.

You can deal a winning hand. That's possibly what this RNA segment

found in both CFS and GWS is - a winning hand. The body shuffles its

way to something that it senses might help, so it remembers it and

makes a lot of copies. These segments float around in the blood on

their way to other cells to make more copies, and they show up on

the test more easily because there are so many of them. The

potential diagnostic marker is actually a winning hand, or as close

as the body can come to one. And it's a marker because everyone

with the same illness will eventually shuffle to the same solution.

Same problem - same helpful answer.

A second possibility is a bust hand. You don't win or lose -

the new segment doesn't help, but it doesn't hurt either. The third

possibility is bad news. Every so often you deal a hand with the

joker in it. The body shuffles and deals out a segment that is a

metabolic toxin. If it is extremely poisonous it will destroy the

cell in which it was created, thus destroying itself. The real

problem is the minor toxins, the ones that make you sick but won't

kill you. You shuffle out enough of these bad hands and it can keep

you from getting well. The hope is that the new treatment Dr.

Cheney is testing, fetal bovine growth factor, will be able to

destroy some or all of these aberrant segments of RNA.

More research is needed to confirm that this segment of RNA is

a diagnostic marker, but Dr. Cheney believes this is by far the best

candidate yet. He also notes that while it would be a genetic

marker, it is not one we are born with . It is one our body creates

in response to this illness.

The study mentioned is entitled " RNAs in the Sera of Persian

Gulf War Veterans Have Segments Homologous to Chromosome 22q11.2 " ,

was written by Urnovitz, Tuite, Higashida, and , and was

published in Clinical and Diagnostic Laboratory Immunology in May

1999, p. 330-335. A transcribed interview with Urnovitz can be

found at:

[Guest guest]

> I wonder what ever happened to the Voyager RNA? -

I just hate this kind of thing because you cant find any info.

Presumably it turned out to be an artifact?

[Guest guest]

Sue - I am glad that lowering intake of these items in your diet (including in

supplements, right?Like the magnesium glycinate?) has continued to help you. I

was not aware that citrates also are excitory, and this is a bit worrisome,

since several of my supplements are in the form of citrates (like magesium

citrate, calcium citrate - supposedly the citrate form is easy for the body to

absorb). I had tried to decrease my mag glycincate intake by going to mag

citrate - so perhaps this is not a good idea? Are citrates cited as being in the

same boat as glycine and gluatmate, regarding the brain, inflammation, and

neuroexcitotoxicity? Thanks - Les PS: Has not ingesting these items helped

improve your insomnia at all?

Re: Genetic Bypass by Amy Yasko

Hi All,

I am also waiting for my " Yasko " genetic test results and agree " Genetic

Bypass " is excellent.

Another great book by Amy Yasko N.D. and Garry Gordon MD is " The Puzzle of

Autism: Putting It All Together " This book is another step further in

explaining the brain inflammation(which really relates to me) and excitotoxins,

RNA viruses, and genetic mutations, etc.. It helps with treatments.

By the way since lowering glutamate, glycine, and citrates out of my diet my

headaches, face tingling and numbness, and eye pain and flshing are gone. I

think it was inflammation. These books help explain this to me . Methyl B12 has

helped heal my nerves.

Things are turning around even more now with adding Yasko to the DAN!

program . . . I believe it will be a mix of both but I am on the " Yasko

Bandwagon " for now. I have back off on DAN! mostly for awhile till I get the

Yasko genetic testing back.

I'll keep you all posted . . . but these books are worth reading.

I was told she has a 5 year waiting list . . . she has to be doing something

right!

Best to all,

Sue T

jill1313 <jenbooks13@...> wrote:

This is a book you get when you order the test kit from testing4health

which is as far as I know, essentially her company...

I have begun the book and just like her lectures, I am really enjoying

it. It's at a very sophisticated level. Rich, you should probably read

it if you haven't before.

Even the beginning jibes so nicely with what I believe. She points out

that in the future we will not be looking at single gene mutations,

but multiple possibilities for mutations in a PATHWAY, that can derail

that pathway. She is not alone in this view, this is the view that is

'seducing' more and more good scientists who are starting to do good

work, esp. epidemiological.

She then points out that the methylation pathway is so important to

look at because it affects immune, neuro, etc. Although I'm of the

belief that immune endocrine and neuro are just one big system that we

think of differently because of its different facets.

I'll report more on this later but for the scientifically minded, it's

good stuff. And, I know DAN folks don't 'respect' her or Gordons

approach but the level of this book shows a deep understanding of the

issues involved. This level of understanding could not have been

achieved without great intelligence and application. I tend to trust

her, therefore.

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Hi ,

I believe the citrates are derived from mold or fungus of some kind. I quit

all my supplements with citrates and it really helped. I believe part of my

problem is also mold related so I believe the citrates aggravated my mold and or

fungus issues. In fact . .I believe Rich had suggested this to me a few days

ago.

Lowering glutamates of any kind especially high protein has also helped .

I tested it last night and had some steak for dinner and I had a bit of a

flare in my brain last night. I really believe Amy Yasko is on track here,

Thanks to Rich he suggested I take the her genetic testing through

www.testingforhealth.com . It really got me interested in reading her books and

watching her DVDs.

My sleeping is sooooo much better since I stopped using the citrates and

glutamates and added in Gaba and Melatonin to balance my brain a little quicker.

Best wishes, Sue T

Masland <lmas@...> wrote:

Sue - I am glad that lowering intake of these items in your diet (including in

supplements, right?Like the magnesium glycinate?) has continued to help you. I

was not aware that citrates also are excitory, and this is a bit worrisome,

since several of my supplements are in the form of citrates (like magesium

citrate, calcium citrate - supposedly the citrate form is easy for the body to

absorb). I had tried to decrease my mag glycincate intake by going to mag

citrate - so perhaps this is not a good idea? Are citrates cited as being in the

same boat as glycine and gluatmate, regarding the brain, inflammation, and

neuroexcitotoxicity? Thanks - Les PS: Has not ingesting these items helped

improve your insomnia at all?

Re: Genetic Bypass by Amy Yasko

Hi All,

I am also waiting for my " Yasko " genetic test results and agree " Genetic

Bypass " is excellent.

Another great book by Amy Yasko N.D. and Garry Gordon MD is " The Puzzle of

Autism: Putting It All Together " This book is another step further in

explaining the brain inflammation(which really relates to me) and excitotoxins,

RNA viruses, and genetic mutations, etc.. It helps with treatments.

By the way since lowering glutamate, glycine, and citrates out of my diet my

headaches, face tingling and numbness, and eye pain and flshing are gone. I

think it was inflammation. These books help explain this to me . Methyl B12 has

helped heal my nerves.

Things are turning around even more now with adding Yasko to the DAN!

program . . . I believe it will be a mix of both but I am on the " Yasko

Bandwagon " for now. I have back off on DAN! mostly for awhile till I get the

Yasko genetic testing back.

I'll keep you all posted . . . but these books are worth reading.

I was told she has a 5 year waiting list . . . she has to be doing something

right!

Best to all,

Sue T

jill1313 <jenbooks13@...> wrote:

This is a book you get when you order the test kit from testing4health

which is as far as I know, essentially her company...

I have begun the book and just like her lectures, I am really enjoying

it. It's at a very sophisticated level. Rich, you should probably read

it if you haven't before.

Even the beginning jibes so nicely with what I believe. She points out

that in the future we will not be looking at single gene mutations,

but multiple possibilities for mutations in a PATHWAY, that can derail

that pathway. She is not alone in this view, this is the view that is

'seducing' more and more good scientists who are starting to do good

work, esp. epidemiological.

She then points out that the methylation pathway is so important to

look at because it affects immune, neuro, etc. Although I'm of the

belief that immune endocrine and neuro are just one big system that we

think of differently because of its different facets.

I'll report more on this later but for the scientifically minded, it's

good stuff. And, I know DAN folks don't 'respect' her or Gordons

approach but the level of this book shows a deep understanding of the

issues involved. This level of understanding could not have been

achieved without great intelligence and application. I tend to trust

her, therefore.

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

In a message dated 2/11/2006 12:04:27 PM Eastern Standard Time,

jenbooks13@... writes:

Oh gosh. That is going to be tough and a lot of work. Perhaps Rich

would be willing as I think he will read it and he likes to summarize.

What is the basis of Amy Yaski's protocol?

mjh

" The Basil Book "

http://foxhillfarm.us/FireBasil/

[Guest guest]

Hi Jill,

I would love to buy those Amy Yasko books and tapes, but they are

very expensive. Can you give us a few highlights?

I was planning to get the Genovations genetic testing done, but now I

am wondering if testing4health would be better?

I also look forward to reading your test results when you post them.

This is very exciting.

Thanks,

Vickie

>

> This is a book you get when you order the test kit from

testing4health

> which is as far as I know, essentially her company...

> I have begun the book and just like her lectures, I am really

enjoying

> it. It's at a very sophisticated level. Rich, you should probably

read

> it if you haven't before.

>

> Even the beginning jibes so nicely with what I believe. She points

out

> that in the future we will not be looking at single gene mutations,

> but multiple possibilities for mutations in a PATHWAY, that can

derail

> that pathway. She is not alone in this view, this is the view that

is

> 'seducing' more and more good scientists who are starting to do good

> work, esp. epidemiological.

>

> She then points out that the methylation pathway is so important to

> look at because it affects immune, neuro, etc. Although I'm of the

> belief that immune endocrine and neuro are just one big system that

we

> think of differently because of its different facets.

>

> I'll report more on this later but for the scientifically minded,

it's

> good stuff. And, I know DAN folks don't 'respect' her or Gordons

> approach but the level of this book shows a deep understanding of

the

> issues involved. This level of understanding could not have been

> achieved without great intelligence and application. I tend to trust

> her, therefore.

>

[Guest guest]

Oh gosh. That is going to be tough and a lot of work. Perhaps Rich

would be willing as I think he will read it and he likes to summarize.

I should also note, her peers in the pioneering world of biomedical

approaches to autism are not impressed with her approach. I've heard

this from a few folks now. I am not taking that to heart, but it is a

bit odd.

> >

> > This is a book you get when you order the test kit from

> testing4health

> > which is as far as I know, essentially her company...

> > I have begun the book and just like her lectures, I am really

> enjoying

> > it. It's at a very sophisticated level. Rich, you should probably

> read

> > it if you haven't before.

> >

> > Even the beginning jibes so nicely with what I believe. She points

> out

> > that in the future we will not be looking at single gene mutations,

> > but multiple possibilities for mutations in a PATHWAY, that can

> derail

> > that pathway. She is not alone in this view, this is the view that

> is

> > 'seducing' more and more good scientists who are starting to do good

> > work, esp. epidemiological.

> >

> > She then points out that the methylation pathway is so important to

> > look at because it affects immune, neuro, etc. Although I'm of the

> > belief that immune endocrine and neuro are just one big system that

> we

> > think of differently because of its different facets.

> >

> > I'll report more on this later but for the scientifically minded,

> it's

> > good stuff. And, I know DAN folks don't 'respect' her or Gordons

> > approach but the level of this book shows a deep understanding of

> the

> > issues involved. This level of understanding could not have been

> > achieved without great intelligence and application. I tend to trust

> > her, therefore.

> >

>

[Guest guest]

She takes a similar approach as other pioneering docs in autism, in

terms of methylation, chronic infection, diet, etc, however, she has

RNA products that supposedly are proprietary and target infections,

metals etc. There is controversy over whether these are effective.

>

> What is the basis of Amy Yaski's protocol?

>

> mjh

> " The Basil Book "

> http://foxhillfarm.us/FireBasil/

>

>

>

[Guest guest]

Hi, Vickie, Jill and the group.

I took your advice, Jill, and ordered Amy Yasko's book " Genetic

Bypass. " If one orders it separately from the gene testing, it

comes with two DVDs of talks she has given at conferences, and the

total cost, with shipping, in the U.S., is $63.07, available from

http://wwww.testing4health.com as the " Nutrigenomics Educational

Starter Packet. "

First, in regard to your recent comments about the outgassing

problems from the book itself, I don't have MCS, and it doesn't

bother me, but if I put my nose up to the pages, I can smell it. I

asked my wife to smell it (She has MCS, serious enough to cause her

very fast headaches from diesel exhaust, paint solvents, carpet

cleaner, bleach, Windex, etc., for example, but probably mild in

comparison to serious MCS cases) and she said she could definitely

smell it, but it didn't seem to bother her, at least right away.

She suggested wearing a respirator. That seems a little awkward to

me, but she does it when she needs to, as in painting kitchens.) I

think that given time the book would outgas. It's probably solvent

in the ink.

Getting to the book's content, I think it makes some very important

contributions. I think it complements the Pangborn and Baker book

rather well, because the latter goes into detail about the

biochemistry in autism, and Amy Yasko's book focuses on the genetic

variations behind the biochemistry, and I think they are both

applicable to CFS.

As I see it (and I'm still trying to digest it all), Amy Yasko's

contributions are several:

1. She has explained the connections between the methylation cycle

and several other cycles in the body (formate, biopterin, urea) and

thus is able to explain some other important things that go on in

these disorders.

2. She has emphasized testing to characterize each person's

combination of genetic variations, and thus to take a lot of the

trial and error out of treatment.

3. She has considered how best to use the various supplements for

at least several of the possible combinations of the genetic

variations. I think these combinations are the origin of at least

several of the subsets in CFS and in autism. One size does not fit

all. She has found, for example, that in some cases

hydroxocobalamin is better than methylcobalamin, and some people do

better on a low protein diet rather than a high protein diet.

4. She includes use of RNA in addition to the other, more common

supplements. I don't understand this part yet, but I do have some

other DVDs of hers that I haven't watched yet that appear to discuss

it.

At this point, my view is that both the DAN! people and Amy Yasko

have made some very important contributions, and I think both the

Pangborn and Baker book and Amy Yasko's book Genetic Bypass are very

important, worthwhile, helpful and complementary books. (By the way,

I think the Genetic Bypass book has much more groundbreaking

information than the older book that Garry Gordon and Amy Yasko

wrote together about autism. I read that one and didn't find it

very helpful as far as saying things I hadn't already learned

elsewhere, or having much of an organized presentation.) I would

suggest reading the Pangborn and Baker book first, to get the

biochemical picture. It is a good book to learn from. Amy Yasko's

book assumes more background on the part of the reader, is perhaps

not as easy to read, but it gets into more specifics about the

particular genetic issues and what to do about them.

It's really interesting to me to consider each of these approaches

and how it looks as though they are all coming together:

1. My own approach, focusing on CFS, starting at pre-onset and

getting up to glutathione depletion and elaborating its effects, but

only recently realizing the importance of the BIG WORLD ahead of

that in the sulfur metabolism and the genes that affect it (because

of the work of Jill and others), which explain the propensity

of certain people to get CFS as well as the vicious circle that

keeps them ill once they get sick, and also points toward treatment

of root causes.

2. Dr. Myhill's and Dr. McLaren 's approach

focused on the mitochondria in ME (CFS), producing some very

definitive testing that proves mitochondrial involvement and some

helpful treatment, but apparently not yet connected to glutathione

depletion and the methylation cycle or the genetics that are behind

the issues that develop in CFS, though I'm expecting that this will

occur, since wrote me that she was ordering the Pangborn and

Baker book.

3. Dr. Cheney, who originally pointed out that there was

glutathione depletion in nearly all his CFS patients (in 1999), who

has done considerable genetic testing of his patients via

Genovations for several years, who has used many of the supplements

for CFS patients that are now used by the DAN! doctors and Amy Yasko

in autistics (including pioneering very high dose B12), who knows

that mitochondrial problems are fundamental in CFS, and who is now

focussing on diastolic heart issues in CFS, which he believes stem

from mitochondrial dysfunction, but who so far has apparently not

put it all together.

4. Dr. Enlander, who by some combination of clinical

experience, biochemical understanding, and insight, put together a

very successful injection and oral supplement for his CFS patients

several years ago that turn out to impact the sulfur metabolism in

several constructive ways, which I have only recently begun to

understand, in the light of the work of others.

5. The DAN! group's emphasis on the biochemistry of the methylation

cycle and how to correct its problems using nutritional supplements,

but really focussing only on autism, not really mentioning CFS at

all. It was news to them when I told them that CFS has the same

issues.

6. Amy Yasko, focused primarily on autism, but recognizing the

bigger picture of many other diseases affected, including CFS, and

primarily going after identifying the genetic variations that affect

not only the methylation cycle but also the other cycles connected

to it, using both common nutritional supplements, but also RNA, but

perhaps not trying to explain how all the symptoms arise in detail,

perhaps not understanding all the aspects that are produced by

glutathione depletion per se, but seeing glutathione depletion as an

aspect of genetic problems in the sulfur metabolism.

It is my opinion that all of this is coming together for CFS, and I

am trying to help that along however I can. There is just so much

to do, that it's hard to know what to try to do first. It's an

extremely exciting time in CFS research, at least for those who see

the " handwriting on the wall. "

Rich

> >

> > Hi Jill,

> >

> > I would love to buy those Amy Yasko books and tapes, but they

are

> > very expensive. Can you give us a few highlights?

> >

> > I was planning to get the Genovations genetic testing done, but

now I

> > am wondering if testing4health would be better?

> >

> > I also look forward to reading your test results when you post

them.

> > This is very exciting.

> >

> > Thanks,

> >

> > Vickie

[Guest guest]

Hi Rich, thanx.

I'm not chemically sensitive to the book persay, I just don't like the

smell and that it comes off on my fingers. So I notice it while I'm

reading and find it unpleasant. Which is quite different than my

horrific silicone caulk experience of late, where the stuff must've

had tons of terrible solvents in it and was a disaster because used in

my bedroom without venting.

Rich, ya got a book in ya...if you want. You can self publish these

days. It would be a useful adjunct to all that is coming together in

the field of autism, but with an overview to cfs, alzheimer's,

parkinsons you name it.

Maybe not right away but there's no reason you should be doin gall

this work and not write a book.

[Guest guest]

Hi, Jill.

Thanks for the encouragement. My wife and I are actually thinking

in that direction, too. She has worked as a professional writer.

(I've actually also recently had five or six offers to collaborate.)

Assuming I live long enough, and my brain keeps functioning, a book

could happen, but I want to try to get something into the peer-

reviewed literature first. If I don't do that, the chances of

having these things eventually picked up by the medical textbooks

and the med school curricula are probably pretty nil. And you know

what that means for PWCs who go to doctors in the future. I haven't

made a secret of things, so even if I were to check out, hopefully

somebody would pick up the ball. Don't get me wrong, I'm healthy

and don't have immediate plans to lose my marbles or to drop into

the box, but I'm also going on 64!

Rich

>

> Hi Rich, thanx.

> I'm not chemically sensitive to the book persay, I just don't like

the

> smell and that it comes off on my fingers. So I notice it while I'm

> reading and find it unpleasant. Which is quite different than my

> horrific silicone caulk experience of late, where the stuff must've

> had tons of terrible solvents in it and was a disaster because

used in

> my bedroom without venting.

>

> Rich, ya got a book in ya...if you want. You can self publish these

> days. It would be a useful adjunct to all that is coming together

in

> the field of autism, but with an overview to cfs, alzheimer's,

> parkinsons you name it.

>

> Maybe not right away but there's no reason you should be doin gall

> this work and not write a book.

>

[Guest guest]

Rich, forgive me if I admit I don't know a lot about you, and

actually, except for your post about Teller, I don't really know what

you'v done and if you are a scientist and what kind. If you are a

scientist however you are not specializing in this arena and have

" only " done a literature review, I'd think the best you could hope for

was for instance an article in Medical Hypotheses which is something

but...won't have that much impact? Again, I could be wrong, maybe very

wrong who knows.

As for 64, assuming you caught your rectal cancer early, you now know

all the info to keep your cells percolating along very well! And live

to 94. I didn't know your wife had MCS. Anyway I tolerate gasoline,

windex, and my vaunted framesi hair dye and all that stuff fine but I

am apparently totally felled by whatever crap is in silicone caulk

that is used for weatherproofing. I also am bad with synthetic carpets

that have formaldehyde, and particle board that has formaldehyde, and

I ain't a big fan of oil based polyruethane either. I just LOVE

bioshield paints, they actually smell good and no toxins at all. And

Seventh Generation makes nice laundry detergents and " windex " that

smells good.

> >

> > Hi Rich, thanx.

> > I'm not chemically sensitive to the book persay, I just don't like

> the

> > smell and that it comes off on my fingers. So I notice it while I'm

> > reading and find it unpleasant. Which is quite different than my

> > horrific silicone caulk experience of late, where the stuff must've

> > had tons of terrible solvents in it and was a disaster because

> used in

> > my bedroom without venting.

> >

> > Rich, ya got a book in ya...if you want. You can self publish these

> > days. It would be a useful adjunct to all that is coming together

> in

> > the field of autism, but with an overview to cfs, alzheimer's,

> > parkinsons you name it.

> >

> > Maybe not right away but there's no reason you should be doin gall

> > this work and not write a book.

> >

>

[Guest guest]

Hi, Jill.

Yeah, Medical Hypotheses is what I'm thinking about. Yes, you're

right, my credentials are elsewhere when it comes to impressing the

biomedical editors and peer reviewers. And you may be absolutely

right about low impact from Med Hypotheses papers. On the other

hand, it is at least listed in Medline, and people reviewing the med

literature would see it. In addition, I continue to interact

with " bonafide " biomed researchers, and something may come of that.

If you want to know about my torrid past, Google me sometime!

I hope you're right about my cells!

I'm glad you've found some tolerable chemical stuff that works for

you.

Rich

> > >

> > > Hi Rich, thanx.

> > > I'm not chemically sensitive to the book persay, I just don't

like

> > the

> > > smell and that it comes off on my fingers. So I notice it

while I'm

> > > reading and find it unpleasant. Which is quite different than

my

> > > horrific silicone caulk experience of late, where the stuff

must've

> > > had tons of terrible solvents in it and was a disaster because

> > used in

> > > my bedroom without venting.

> > >

> > > Rich, ya got a book in ya...if you want. You can self publish

these

> > > days. It would be a useful adjunct to all that is coming

together

> > in

> > > the field of autism, but with an overview to cfs, alzheimer's,

> > > parkinsons you name it.

> > >

> > > Maybe not right away but there's no reason you should be doin

gall

> > > this work and not write a book.

> > >

> >

>

[Guest guest]

Okay I'll google you later.

What bugs me is that I know I'm sensitive to something as my body

tells me right away. Why in the world did I flee from my bedroom when

he started using that caulk? It made me dizzy! Why did I not stop him.

I cannot believe my own idiocy sometimes. So in the end I fault myself.

I don't think Medical Hypotheses will have so much of an impact.

Sherr had something in there, and what impact has that had?

NADA as far as I can see.

But a book for the emerging grassroots movement, would help folks!

My bias is to that though.

I swear I'm about ready to start a little publishing venture and

publish people I think are worthwhile. A few such books have come my

way, and I've been meaning to start a self publishing venture later

this year if I get the time.

> > > >

> > > > Hi Rich, thanx.

> > > > I'm not chemically sensitive to the book persay, I just don't

> like

> > > the

> > > > smell and that it comes off on my fingers. So I notice it

> while I'm

> > > > reading and find it unpleasant. Which is quite different than

> my

> > > > horrific silicone caulk experience of late, where the stuff

> must've

> > > > had tons of terrible solvents in it and was a disaster because

> > > used in

> > > > my bedroom without venting.

> > > >

> > > > Rich, ya got a book in ya...if you want. You can self publish

> these

> > > > days. It would be a useful adjunct to all that is coming

> together

> > > in

> > > > the field of autism, but with an overview to cfs, alzheimer's,

> > > > parkinsons you name it.

> > > >

> > > > Maybe not right away but there's no reason you should be doin

> gall

> > > > this work and not write a book.

> > > >

> > >

> >

>

[Guest guest]

Wow, Rich, you really made my day with all this information. You have

really hit the Jackpot in bringing all this together. I guess the

Full Moon has a good effect on you!

Vickie

>Rich wrote:

>

> Hi, Vickie, Jill and the group.

>

> I took your advice, Jill, and ordered Amy Yasko's book " Genetic

> Bypass. " If one orders it separately from the gene testing, it

> comes with two DVDs of talks she has given at conferences, and the

> total cost, with shipping, in the U.S., is $63.07, available from

> http://wwww.testing4health.com as the " Nutrigenomics Educational

> Starter Packet. "

>

> First, in regard to your recent comments about the outgassing

> problems from the book itself, I don't have MCS, and it doesn't

> bother me, but if I put my nose up to the pages, I can smell it. I

> asked my wife to smell it (She has MCS, serious enough to cause her

> very fast headaches from diesel exhaust, paint solvents, carpet

> cleaner, bleach, Windex, etc., for example, but probably mild in

> comparison to serious MCS cases) and she said she could definitely

> smell it, but it didn't seem to bother her, at least right away.

> She suggested wearing a respirator. That seems a little awkward to

> me, but she does it when she needs to, as in painting kitchens.) I

> think that given time the book would outgas. It's probably solvent

> in the ink.

>

> Getting to the book's content, I think it makes some very important

> contributions. I think it complements the Pangborn and Baker book

> rather well, because the latter goes into detail about the

> biochemistry in autism, and Amy Yasko's book focuses on the genetic

> variations behind the biochemistry, and I think they are both

> applicable to CFS.

>

> As I see it (and I'm still trying to digest it all), Amy Yasko's

> contributions are several:

>

> 1. She has explained the connections between the methylation cycle

> and several other cycles in the body (formate, biopterin, urea) and

> thus is able to explain some other important things that go on in

> these disorders.

>

> 2. She has emphasized testing to characterize each person's

> combination of genetic variations, and thus to take a lot of the

> trial and error out of treatment.

>

> 3. She has considered how best to use the various supplements for

> at least several of the possible combinations of the genetic

> variations. I think these combinations are the origin of at least

> several of the subsets in CFS and in autism. One size does not fit

> all. She has found, for example, that in some cases

> hydroxocobalamin is better than methylcobalamin, and some people do

> better on a low protein diet rather than a high protein diet.

>

> 4. She includes use of RNA in addition to the other, more common

> supplements. I don't understand this part yet, but I do have some

> other DVDs of hers that I haven't watched yet that appear to

discuss

> it.

>

> At this point, my view is that both the DAN! people and Amy Yasko

> have made some very important contributions, and I think both the

> Pangborn and Baker book and Amy Yasko's book Genetic Bypass are

very

> important, worthwhile, helpful and complementary books. (By the

way,

> I think the Genetic Bypass book has much more groundbreaking

> information than the older book that Garry Gordon and Amy Yasko

> wrote together about autism. I read that one and didn't find it

> very helpful as far as saying things I hadn't already learned

> elsewhere, or having much of an organized presentation.) I would

> suggest reading the Pangborn and Baker book first, to get the

> biochemical picture. It is a good book to learn from. Amy Yasko's

> book assumes more background on the part of the reader, is perhaps

> not as easy to read, but it gets into more specifics about the

> particular genetic issues and what to do about them.

>

> It's really interesting to me to consider each of these approaches

> and how it looks as though they are all coming together:

>

> 1. My own approach, focusing on CFS, starting at pre-onset and

> getting up to glutathione depletion and elaborating its effects,

but

> only recently realizing the importance of the BIG WORLD ahead of

> that in the sulfur metabolism and the genes that affect it (because

> of the work of Jill and others), which explain the propensity

> of certain people to get CFS as well as the vicious circle that

> keeps them ill once they get sick, and also points toward treatment

> of root causes.

>

> 2. Dr. Myhill's and Dr. McLaren 's approach

> focused on the mitochondria in ME (CFS), producing some very

> definitive testing that proves mitochondrial involvement and some

> helpful treatment, but apparently not yet connected to glutathione

> depletion and the methylation cycle or the genetics that are behind

> the issues that develop in CFS, though I'm expecting that this will

> occur, since wrote me that she was ordering the Pangborn and

> Baker book.

>

> 3. Dr. Cheney, who originally pointed out that there was

> glutathione depletion in nearly all his CFS patients (in 1999), who

> has done considerable genetic testing of his patients via

> Genovations for several years, who has used many of the supplements

> for CFS patients that are now used by the DAN! doctors and Amy

Yasko

> in autistics (including pioneering very high dose B12), who knows

> that mitochondrial problems are fundamental in CFS, and who is now

> focussing on diastolic heart issues in CFS, which he believes stem

> from mitochondrial dysfunction, but who so far has apparently not

> put it all together.

>

> 4. Dr. Enlander, who by some combination of clinical

> experience, biochemical understanding, and insight, put together a

> very successful injection and oral supplement for his CFS patients

> several years ago that turn out to impact the sulfur metabolism in

> several constructive ways, which I have only recently begun to

> understand, in the light of the work of others.

>

> 5. The DAN! group's emphasis on the biochemistry of the

methylation

> cycle and how to correct its problems using nutritional

supplements,

> but really focussing only on autism, not really mentioning CFS at

> all. It was news to them when I told them that CFS has the same

> issues.

>

> 6. Amy Yasko, focused primarily on autism, but recognizing the

> bigger picture of many other diseases affected, including CFS, and

> primarily going after identifying the genetic variations that

affect

> not only the methylation cycle but also the other cycles connected

> to it, using both common nutritional supplements, but also RNA, but

> perhaps not trying to explain how all the symptoms arise in detail,

> perhaps not understanding all the aspects that are produced by

> glutathione depletion per se, but seeing glutathione depletion as

an

> aspect of genetic problems in the sulfur metabolism.

>

> It is my opinion that all of this is coming together for CFS, and I

> am trying to help that along however I can. There is just so much

> to do, that it's hard to know what to try to do first. It's an

> extremely exciting time in CFS research, at least for those who see

> the " handwriting on the wall. "

>

> Rich

>

>

> > >

> > > Hi Jill,

> > >

> > > I would love to buy those Amy Yasko books and tapes, but they

> are

> > > very expensive. Can you give us a few highlights?

> > >

> > > I was planning to get the Genovations genetic testing done, but

> now I

> > > am wondering if testing4health would be better?

> > >

> > > I also look forward to reading your test results when you post

> them.

> > > This is very exciting.

> > >

> > > Thanks,

> > >

> > > Vickie

>