Amino Acid Analysis Attn :Rich

[Guest guest]

Rich,

I've been forward my treating physician Dr. Vrchota all of your latest

theories on glut/mercury/etc. As you know she highly respects your

work. She wants to know if you have you seen info on amino acid

therapy for fatigue using amino acid analysis from

www.neuroscience.com? She said there were quite a few practioners that

thought this was helpful at the last ACAM meeting.

Thanks,

S.

[Guest guest]

Hi, S.

>

> Rich,

>

> I've been forward my treating physician Dr. Vrchota all of your

latest

> theories on glut/mercury/etc. As you know she highly respects

your

> work.

***I happen to think she's pretty O.K., too! Please tell her hi

from me.

She wants to know if you have you seen info on amino acid

> therapy for fatigue using amino acid analysis from

> www.neuroscience.com? She said there were quite a few practioners

that

> thought this was helpful at the last ACAM meeting.

***No, this is a new one on me. I went to the site you mentioned,

but I couldn't find anything there about amino acids analysis.

***I do think that analyzing amino acids can be helpful in

understanding what's going on in CFS. I know a doctor in southern

California named Gersten, who has used amino acids analysis

for several years in CFS patients, and finds that it is very helpful

in treating them. He supplements with a mixture of amino acids

tailored to the results of the amino acids measurements for a

particular patient.

***Quite a few PWCs are low in a whole range of amino acids. I

suspect that this happens because their cells are burning amino

acids for fuel. I think this often results in turn from a partial

blockade in the Krebs cycle at aconitase, which prevents the

efficient use of carbohydrates or fats for fuel. Amino acids can

still be used because they can be transaminated from one to another,

and some of them can enter the Krebs cycle beyond the partial

blockade.

***I think the partial blockade results from elevation of superoxide

and peroxynitrite, which suppress aconitase activity. The rise in

these reactive oxygen species, in turn, comes about because of

glutathione depletion, and that comes from a combination of genetic

variations in enzymes affecting the sulfur metabolism, together with

some combination of physical, chemical, biological and/or

psychological/emotional stressors. This combination forms a vicious

cycle that keeps the person ill.

***I think that supplementing with amino acids can improve the

quality of life, but I don't think it directly addresses the root

problem. However, sometimes success comes when a whole range of

aspects of CFS are dealt with, taking a load off the body and

enabling it to climb back out of the pathophysiological hole

itself. I think it depends on what the genetic polymorphism

combination is, as to whether this will work, or whether a more

direct approach on the sulfur metabolism is necessary. I still have

a lot to learn about this, but fortunately, people like yourself

continue to educate me!

> Thanks,

> S.

You're welcome.

Rich

[Guest guest]

,

I got amino acids testing done from Metametrix and I had the special blend of

amino's made up to suit my personal deficiencies. I could not tolerate it at all

even in small doses. The blocks in my methylation cycle just made too many of

the aminos too hard to tolerate (much more tired, just feeling realy lousy and

less functional when I tried to take them). Its not as simple as they make it

sound.

Marcia

Re: Amino Acid Analysis Attn :Rich

Hi, S.

>

> Rich,

>

> I've been forward my treating physician Dr. Vrchota all of your

latest

> theories on glut/mercury/etc. As you know she highly respects

your

> work.

***I happen to think she's pretty O.K., too! Please tell her hi

from me.

She wants to know if you have you seen info on amino acid

> therapy for fatigue using amino acid analysis from

> www.neuroscience.com? She said there were quite a few practioners

that

> thought this was helpful at the last ACAM meeting.

***No, this is a new one on me. I went to the site you mentioned,

but I couldn't find anything there about amino acids analysis.

***I do think that analyzing amino acids can be helpful in

understanding what's going on in CFS. I know a doctor in southern

California named Gersten, who has used amino acids analysis

for several years in CFS patients, and finds that it is very helpful

in treating them. He supplements with a mixture of amino acids

tailored to the results of the amino acids measurements for a

particular patient.

***Quite a few PWCs are low in a whole range of amino acids. I

suspect that this happens because their cells are burning amino

acids for fuel. I think this often results in turn from a partial

blockade in the Krebs cycle at aconitase, which prevents the

efficient use of carbohydrates or fats for fuel. Amino acids can

still be used because they can be transaminated from one to another,

and some of them can enter the Krebs cycle beyond the partial

blockade.

***I think the partial blockade results from elevation of superoxide

and peroxynitrite, which suppress aconitase activity. The rise in

these reactive oxygen species, in turn, comes about because of

glutathione depletion, and that comes from a combination of genetic

variations in enzymes affecting the sulfur metabolism, together with

some combination of physical, chemical, biological and/or

psychological/emotional stressors. This combination forms a vicious

cycle that keeps the person ill.

***I think that supplementing with amino acids can improve the

quality of life, but I don't think it directly addresses the root

problem. However, sometimes success comes when a whole range of

aspects of CFS are dealt with, taking a load off the body and

enabling it to climb back out of the pathophysiological hole

itself. I think it depends on what the genetic polymorphism

combination is, as to whether this will work, or whether a more

direct approach on the sulfur metabolism is necessary. I still have

a lot to learn about this, but fortunately, people like yourself

continue to educate me!

> Thanks,

> S.

You're welcome.

Rich

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Marcia,

Thanks for sharing your experience. Do you know where your blocks

are?

S.

> >

> > Rich,

> >

> > I've been forward my treating physician Dr. Vrchota all of

your

> latest

> > theories on glut/mercury/etc. As you know she highly respects

> your

> > work.

>

> ***I happen to think she's pretty O.K., too! Please tell her hi

> from me.

>

> She wants to know if you have you seen info on amino acid

> > therapy for fatigue using amino acid analysis from

> > www.neuroscience.com? She said there were quite a few

practioners

> that

> > thought this was helpful at the last ACAM meeting.

>

> ***No, this is a new one on me. I went to the site you

mentioned,

> but I couldn't find anything there about amino acids analysis.

>

> ***I do think that analyzing amino acids can be helpful in

> understanding what's going on in CFS. I know a doctor in

southern

> California named Gersten, who has used amino acids

analysis

> for several years in CFS patients, and finds that it is very

helpful

> in treating them. He supplements with a mixture of amino acids

> tailored to the results of the amino acids measurements for a

> particular patient.

>

> ***Quite a few PWCs are low in a whole range of amino acids. I

> suspect that this happens because their cells are burning amino

> acids for fuel. I think this often results in turn from a

partial

> blockade in the Krebs cycle at aconitase, which prevents the

> efficient use of carbohydrates or fats for fuel. Amino acids

can

> still be used because they can be transaminated from one to

another,

> and some of them can enter the Krebs cycle beyond the partial

> blockade.

>

> ***I think the partial blockade results from elevation of

superoxide

> and peroxynitrite, which suppress aconitase activity. The rise

in

> these reactive oxygen species, in turn, comes about because of

> glutathione depletion, and that comes from a combination of

genetic

> variations in enzymes affecting the sulfur metabolism, together

with

> some combination of physical, chemical, biological and/or

> psychological/emotional stressors. This combination forms a

vicious

> cycle that keeps the person ill.

>

> ***I think that supplementing with amino acids can improve the

> quality of life, but I don't think it directly addresses the

root

> problem. However, sometimes success comes when a whole range of

> aspects of CFS are dealt with, taking a load off the body and

> enabling it to climb back out of the pathophysiological hole

> itself. I think it depends on what the genetic polymorphism

> combination is, as to whether this will work, or whether a more

> direct approach on the sulfur metabolism is necessary. I still

have

> a lot to learn about this, but fortunately, people like yourself

> continue to educate me!

>

> > Thanks,

> > S.

>

>

> You're welcome.

> Rich

>

>

>

>

>

> This list is intended for patients to share personal experiences

with each other, not to give medical advice. If you are interested

in any treatment discussed here, please consult your doctor.

>

>

>

>

[Guest guest]

Marcia,

Thanks for sharing your experience. Do you know where your blocks

are?

S.

> >

> > Rich,

> >

> > I've been forward my treating physician Dr. Vrchota all of

your

> latest

> > theories on glut/mercury/etc. As you know she highly respects

> your

> > work.

>

> ***I happen to think she's pretty O.K., too! Please tell her hi

> from me.

>

> She wants to know if you have you seen info on amino acid

> > therapy for fatigue using amino acid analysis from

> > www.neuroscience.com? She said there were quite a few

practioners

> that

> > thought this was helpful at the last ACAM meeting.

>

> ***No, this is a new one on me. I went to the site you

mentioned,

> but I couldn't find anything there about amino acids analysis.

>

> ***I do think that analyzing amino acids can be helpful in

> understanding what's going on in CFS. I know a doctor in

southern

> California named Gersten, who has used amino acids

analysis

> for several years in CFS patients, and finds that it is very

helpful

> in treating them. He supplements with a mixture of amino acids

> tailored to the results of the amino acids measurements for a

> particular patient.

>

> ***Quite a few PWCs are low in a whole range of amino acids. I

> suspect that this happens because their cells are burning amino

> acids for fuel. I think this often results in turn from a

partial

> blockade in the Krebs cycle at aconitase, which prevents the

> efficient use of carbohydrates or fats for fuel. Amino acids

can

> still be used because they can be transaminated from one to

another,

> and some of them can enter the Krebs cycle beyond the partial

> blockade.

>

> ***I think the partial blockade results from elevation of

superoxide

> and peroxynitrite, which suppress aconitase activity. The rise

in

> these reactive oxygen species, in turn, comes about because of

> glutathione depletion, and that comes from a combination of

genetic

> variations in enzymes affecting the sulfur metabolism, together

with

> some combination of physical, chemical, biological and/or

> psychological/emotional stressors. This combination forms a

vicious

> cycle that keeps the person ill.

>

> ***I think that supplementing with amino acids can improve the

> quality of life, but I don't think it directly addresses the

root

> problem. However, sometimes success comes when a whole range of

> aspects of CFS are dealt with, taking a load off the body and

> enabling it to climb back out of the pathophysiological hole

> itself. I think it depends on what the genetic polymorphism

> combination is, as to whether this will work, or whether a more

> direct approach on the sulfur metabolism is necessary. I still

have

> a lot to learn about this, but fortunately, people like yourself

> continue to educate me!

>

> > Thanks,

> > S.

>

>

> You're welcome.

> Rich

>

>

>

>

>

> This list is intended for patients to share personal experiences

with each other, not to give medical advice. If you are interested

in any treatment discussed here, please consult your doctor.

>

>

>

>

[Guest guest]

Hi, S. and the group.

I noticed from Adrienne's fortuitously timed e-mail that the correct

website name has an " inc " in it:

http://www.neuroscienceinc.com

So I found it, and I would say that it looks very good. They have

clearly done their homework on the neurotransmitters.

As I said before, I think that adjusting the neurotransmitters could

help the quality of life for many PWCs. However, in the longer

term, I think that it's important to figure out why the

neurotransmitters were out of whack and to fix that. After all,

most PWCs were healthy at one time. They must be genetically able

to achieve a neurotransmitter balance that is at least more or less

O.K., if perhaps not optimum. Now that I have read Amy Yasko's

stuff a little, I can see how a block in sulfur metabolism can

transfer to a problem in folate metabolism and a problem in

biopterin metabolism, which affects both dopamine and serotonin

production. In addition, a drop in methylation capacity affects the

conversion of serotonin to melatonin.

So I guess my view of this is that it seems as though it could

provide some help, but that going to the root of the problems will

likely be more productive in the long run.

Rich

> >

> > Rich,

> >

> > I've been forward my treating physician Dr. Vrchota all of your

> latest

> > theories on glut/mercury/etc. As you know she highly respects

> your

> > work.

>

> ***I happen to think she's pretty O.K., too! Please tell her hi

> from me.

>

> She wants to know if you have you seen info on amino acid

> > therapy for fatigue using amino acid analysis from

> > www.neuroscience.com? She said there were quite a few

practioners

> that

> > thought this was helpful at the last ACAM meeting.

>

> ***No, this is a new one on me. I went to the site you mentioned,

> but I couldn't find anything there about amino acids analysis.

>

> ***I do think that analyzing amino acids can be helpful in

> understanding what's going on in CFS. I know a doctor in southern

> California named Gersten, who has used amino acids analysis

> for several years in CFS patients, and finds that it is very

helpful

> in treating them. He supplements with a mixture of amino acids

> tailored to the results of the amino acids measurements for a

> particular patient.

>

> ***Quite a few PWCs are low in a whole range of amino acids. I

> suspect that this happens because their cells are burning amino

> acids for fuel. I think this often results in turn from a partial

> blockade in the Krebs cycle at aconitase, which prevents the

> efficient use of carbohydrates or fats for fuel. Amino acids can

> still be used because they can be transaminated from one to

another,

> and some of them can enter the Krebs cycle beyond the partial

> blockade.

>

> ***I think the partial blockade results from elevation of

superoxide

> and peroxynitrite, which suppress aconitase activity. The rise in

> these reactive oxygen species, in turn, comes about because of

> glutathione depletion, and that comes from a combination of

genetic

> variations in enzymes affecting the sulfur metabolism, together

with

> some combination of physical, chemical, biological and/or

> psychological/emotional stressors. This combination forms a

vicious

> cycle that keeps the person ill.

>

> ***I think that supplementing with amino acids can improve the

> quality of life, but I don't think it directly addresses the root

> problem. However, sometimes success comes when a whole range of

> aspects of CFS are dealt with, taking a load off the body and

> enabling it to climb back out of the pathophysiological hole

> itself. I think it depends on what the genetic polymorphism

> combination is, as to whether this will work, or whether a more

> direct approach on the sulfur metabolism is necessary. I still

have

> a lot to learn about this, but fortunately, people like yourself

> continue to educate me!

>

> > Thanks,

> > S.

>

>

> You're welcome.

> Rich

>