Re: Genovations testing - jen1313

[Guest guest]

Sue, thanks for the information on Genovations SNPs. Do you know how

much it costs to get all five panels done? $1 a SNP sounds

affordable, but how many SNPs are involved? Thanks,

Vickie

>

> Hi Jill,

>

> I'm a week behind on this list, but at some point you were

expressing

> frustration about not being able to get enough information about

the

> Genovations tests. Me, too. It would be helpful if Genovations

would

> at least list what SNPs they are testing for in their five panels,

but

> they don't.

>

> About a month ago I visited the website of an osteopathic physician

in

> Illinois--Dr. Feely. He reproduced a patient's Genovations

> report--without the patient's name. The patient had done four of

the

> five Genovations panels, and the SNPs were there for all to see--

along

> with Genovations' detailed comments on the test results.

>

> I tried to find that page on Dr. Feely's website just now so I

could

> post a link, and it's gone. I'll bet that Genovations got to him

and

> threatened him and he took it down. For one thing, maybe

Genovations

> doesn't want us shopping around for prices on SNPs. I've read that

the

> cost for the companies that do this has come down from $1 per SNP

to 50

> cents. Yet the best retail price I've found is $10 per SNP

(Sciona).

>

> I say this, knowing that the price per SNP is probably a minor

> consideration. What's more important is which SNPs are chosen and

what

> is known about them. The Genovations report that comes with their

test

> results is probably quite valuable.

>

> Anyway, fortunately, I had printed out Dr. Feely's report. I'm

going

> to copy it now so that everyone can see it because I'm pissed off

at

> Genovations for being so secretive and at the New York State

government

> for preventing us New Yorkers from getting these tests.

>

> Unfortunately the panel that we'd be most interested in--the

> NeuroGenomic™Profile--was not included on Dr. Feely's website. I

guess

> his patient didn't have that one done. Here's what Genovations says

> about this: " Evaluates SNPs that modulate methylation, glutathione

> conjugation and oxidative protection. " But the four others panels

were

> detailed on Feely's website, and I've copied them below. Please

excuse

> typos.

>

>

> CardioGenomic®Profile (13 SNPs)

> Evaluates genetic variations (SNPs) that modulate blood pressure

> regulation, lipid balance, nutrient metabolism, inflammation, and

> oxidative stress.

>

> APO E

> CETP (Taq1B, Rsa I, D422G)

> SELE (98G0%, 128R)

> MTHFR (6767C-T)

> GNB3 (825C-T)

> AGT (M235T)

> AGTR1 (1166A-C)

> Factor 2 (G20210A)

> Factor 5 (R506Q)

> CYBA*8 (H72Y)

>

>

> ImmuneGenomics (4 SNPs)

> Evaluates SNPs that modulate immune and inflammatory activity.

> Polymorphisms affect the levels and activity of the cytokines.

These

> variations can affect balance between cell (TH-1) and humoral (TH-

2)

> immunity, reveal potential defects in immune system defense, and

> stimulate mechanisms leading to chronic, overactive inflammatory

> responses.

>

> TNF-alpha (308G-A)

> IL-6 (174G-C)

> IL-10 (627C-A)

> IL-13 (R130Q)

>

>

> DetoxiGenomics (22 SNPs)

> Evaluates SNPs associated with increased risk of impaired

> detoxification capacity especially when exposed to environmental

> toxins. It also identifies individuals potentially susceptible to

> adverse drug reactions.

>

> (NOTE: The SNPs below that I've marked with an asterisk are

included in

> one of the panels done by another company--Genelex. Those three

SNPs

> plus (CYP?) 1A2 cost $800 at Genelex!)

>

> CYP1!a

> CYP1B1

> CYP2A6

> * CYP2C9

> * CYP2C19

> * CYP2D6

> CYP2E1

> CYP3A4

> COMT

> NAT1 (R64WJ)

> NAT1 (R187Q)

> NAT2 (l114T)

> NAT2 (R197Q)

> NAT2 (G286E)

> NAT2 (R64Q)

> NAT2 (K286R)

> GSTM1 (1p13.3)

> GSTP1 J(L104V)

> GSTP1 (l104V)

> GSTP1 (A113V)

> SOD1 (G93!)

> SOD1 (A4V)

> SOD2 (16V)

>

>

> Osteo Genomics 5 SNPs

> Evaluates SNPs that modulate bone formation (collagen synthesis),

bone

> breakdown (resorption), and inflammation, including key regulatory

> mechanisms affecting calcium and Vitamin D3 metabolism.

>

> COL1A1 (2046G-T)

> CALCR (P463L)

> VDR (RFLP)

> IL-6 (174G-C)

> TNF-alpha (308G-A)

>

>

> Sue ,

> Upstate New York

>