Re: Rich: Mercury, Apolipoprotein E4 Genotype...?

[Guest guest]

Hi, shakerz25.

The connection between apolipoprotein E4 genotype and problems with

mercury detox was new to me, but I did find the following abstracts

on PubMed:

" J Alzheimers Dis. 2003 Jun;5(3):189-95.

Apolipoprotein E genotyping as a potential biomarker for mercury

neurotoxicity.

Godfrey ME, Wojcik DP, Krone CA.

Bay of Plenty Environmental Health Clinic, Tauranga, New Zealand.

godfrey@...

Apolipoprotein-E (apo-E) genotyping has been investigated as an

indicator of susceptibility to heavy metal (i.e., lead)

neurotoxicity. Moreover, the apo-E epsilon (epsilon)4 allele is a

major risk factor for neurodegenerative conditions, including

Alzheimer's disease (AD). A theoretical biochemical basis for this

risk factor is discussed herein, supported by data from 400 patients

with presumptive mercury-related neuro-psychiatric symptoms and in

whom apo-E determinations were made. A statistically relevant shift

toward the at-risk apo-E epsilon4 groups was found in the patients

p<0.001). The patients possessed a mean of 13.7 dental amalgam

fillings and 31.5 amalgam surfaces. This far exceeds the number

capable of producing the maximum identified tolerable daily intake

of mercury from amalgam. The clinical diagnosis and proof of chronic

low-level mercury toxicity has been difficult due to the non-

specific nature of the symptoms and signs. Dental amalgam is the

greatest source of mercury in the general population and brain,

blood and urine mercury levels increase correspondingly with the

number of amalgams and amalgam surfaces in the mouth. Confirmation

of an elevated body burden of mercury can be made by measuring

urinary mercury, after provocation with 2,3,-dimercapto-propane

sulfonate (DMPS) and this was measured in 150 patients. Apo-E

genotyping warrants investigation as a clinically useful biomarker

for those at increased risk of neuropathology, including AD, when

subjected to long-term mercury exposures. Additionally, when

clinical findings suggest adverse effects of chronic mercury

exposure, a DMPS urine mercury challenge appears to be a simple,

inexpensive procedure that provides objective confirmatory evidence.

An opportunity could now exist for primary health practitioners to

help identify those at greater risk and possibly forestall

subsequent neurological deterioration.

PMID: 12897404 [PubMed - indexed for MEDLINE] "

" Neuro Endocrinol Lett. 2004 Oct;25(5):331-9.

Alzheimer disease: mercury as pathogenetic factor and apolipoprotein

E as a moderator.

Mutter J, Naumann J, Sadaghiani C, Schneider R, Walach H.

Institute for Environmental Medicine and Hospital Epidemiology,

University Hospital Freiburg, Germany. jmutter@...-

freiburg.de

The etiology of most cases of Alzheimer's disease (AD) is as yet

unknown. Epidemiological studies suggest that environmental factors

may be involved beside genetic risk factors. Some studies have shown

higher mercury concentrations in brains of deceased and in blood of

living patients with Alzheimer's disease. Experimental studies have

found that even smallest amounts of mercury but no other metals in

low concentrations were able to cause all nerve cell changes, which

are typical for Alzheimer's disease. The most important genetic risk

factor for sporadic Alzheimer's disease is the presence of the

apolipoprotein Ee4 allele whereas the apolipoprotein Ee2 allele

reduces the risk of developing Alzheimer's disease. Some

investigators have suggested that apolipoprotein Ee4 has a reduced

ability to bind metals like mercury and therefore explain the higher

risk for Alzheimer's disease. Therapeutic approaches embrace

pharmaceuticals which bind metals in the brain of patients with

Alzheimer's disease. In sum, both the findings from epidemiological

and demographical studies, the frequency of amalgam application in

industrialized countries, clinical studies, experimental studies and

the dental state of AD patients in comparison to controls suggest a

decisive role for inorganic mercury in the etiology of AD.

Publication Types:

Review

PMID: 15580166 [PubMed - indexed for MEDLINE] "

Considering testing, I note that Googling turned up at least one lab

that offers apolipoprotein E genotyping.

Considering differences in detox protocols, I'm not sure. I'll have

to try to understand how apolipoprotein E is involved in mercury

transport.

Thanks for raising this issue.

Rich

>

> Rich et al,

>

> If this has been discussed before, forgive me (nothing came up in

a

> search).

>

> I just read this on a doctor's website, wondering if you can

comment on

> it:

> " For example, people with an Apolipoprotein E4 Genotype lack the

> ability to shuttle mercury out of the cells. As their body is

unable to

> detoxify, mercury accumulates in the cells and promotes disease. "

>

> Is this generally accepted in the mercury detox field, is there

useful

> testing, and would detox protocols be different for people with

this

> issue?

>

> If this topic is not appropiate to this list or has been covered,

> please e-mail me. Thanks!

>

[Guest guest]

Parents of autistic kids are looking at both apo3 and apo4 as one of

the markers for poor detox of metals.

> >

> > Rich et al,

> >

> > If this has been discussed before, forgive me (nothing came up in

> a

> > search).

> >

> > I just read this on a doctor's website, wondering if you can

> comment on

> > it:

> > " For example, people with an Apolipoprotein E4 Genotype lack the

> > ability to shuttle mercury out of the cells. As their body is

> unable to

> > detoxify, mercury accumulates in the cells and promotes disease. "

> >

> > Is this generally accepted in the mercury detox field, is there

> useful

> > testing, and would detox protocols be different for people with

> this

> > issue?

> >

> > If this topic is not appropiate to this list or has been covered,

> > please e-mail me. Thanks!

> >

>

[Guest guest]

Genovations.com cardio panel measures this along with the gene variants

impacting glutathione status, etc.. My cardio panel through them showed I had

apoe 3,4, while the most common in human population is

apoe 3,3.

And guess which heavy metal I consistently test highest for on both

non-challenge and challenge heavy metal tests?...Lead!....I know apoe 4,4 has

the highest linkage to Alzeheimer's, but anyone with a apoe 4 will be vulnerable

and have brains that allow the deepest penetration of toxins and microbes

according to a personalized report for my case from Dr Cheney in 2002.

EDTA chelation is best suited for lead detox and given my testing profile and

the great indirect indication that I have mercury toxicity as well, I opted for

IV EDTA/DMPS chelation. Garden of Life's " Fungal Defense " therapy in a bottle

from needs.com has been showing good signs of helping my brain too.

" jill1313 " <jenbooks13@h...> wrote:

>

>

> Parents of autistic kids are looking at both apo3 and apo4 as one of

> the markers for poor detox of metals.

>

>

> >

> > Hi, shakerz25.

> >

> > The connection between apolipoprotein E4 genotype and problems with

> > mercury detox was new to me, but I did find the following abstracts

[Guest guest]

Correction...Meant to say Genovations cardio panel shows your apoe profile while

their detox panel shows many gene variants impacting glutathione status.

FWIW, I think its worthwhile to get all five(last I counted) of their SNPs(gene

variant)panels. The results fit quite nicely with the data found in the new

book, Autism: Effective Biomedical Treatments, which is fast becoming the MUST

read and possible watershed book for PWME/CFIDS/Lyme treatment in 2006.

" davidhall2020 " <davidhall@w...> wrote:

>

> Genovations.com cardio panel measures this along with the gene variants

impacting glutathione status, etc.. My cardio panel through them showed I had

> apoe 3,4, while the most common in human population is

> apoe 3,3.

>

>

>

> And guess which heavy metal I consistently test highest for on both

non-challenge and challenge heavy metal tests?...Lead!....I know apoe 4,4 has

the highest linkage to Alzeheimer's, but anyone with a apoe 4 will be vulnerable

and have brains that allow the deepest penetration of toxins and microbes

according to a personalized report for my case from Dr Cheney in 2002.

>

>

>

> EDTA chelation is best suited for lead detox and given my testing profile and

the great indirect indication that I have mercury toxicity as well, I opted for

IV EDTA/DMPS chelation. Garden of Life's " Fungal Defense " therapy in a bottle

from needs.com has been showing good signs of helping my brain too.

>

>

>

>

>

>

>

>

>

>

> " jill1313 " <jenbooks13@h...> wrote:

> >

> >

> > Parents of autistic kids are looking at both apo3 and apo4 as one of

> > the markers for poor detox of metals.

> >

> >

> > >

> > > Hi, shakerz25.

> > >

> > > The connection between apolipoprotein E4 genotype and problems with

> > > mercury detox was new to me, but I did find the following abstracts

>

[Guest guest]

Thanx for the info . Exactly what tests did you get if you don't

mind telling me? I'm going to ask for some testing next week.

> > >

> > > Hi, shakerz25.

> > >

> > > The connection between apolipoprotein E4 genotype and problems with

> > > mercury detox was new to me, but I did find the following abstracts

>

[Guest guest]

That's the DAN book I just read, correct?

Can you list all the tests you are recommending?

I agree, the protocol in that book is pretty brilliant and applies to

all of us. The only thing some of the autism researchers are leaving

out a little too much imo is borrelia.

> > > >

> > > > Hi, shakerz25.

> > > >

> > > > The connection between apolipoprotein E4 genotype and problems

with

> > > > mercury detox was new to me, but I did find the following

abstracts

> >

>

[Guest guest]

Hi Jill,

Message: 25

Date: Thu, 05 Jan 2006 21:55:19 -0000

From: " jill1313 " <jenbooks13@...>

Subject: Re: Rich: Mercury, Apolipoprotein E4 Genotype...?

> That's the DAN book I just read, correct?... the protocol in that book

> is pretty brilliant and applies to

> all of us.

Have you figured out why Amy Yasko is not mentioned in this book?

(Maybe I just haven't gotten far enough in it?)

Sue ,

Upstate New York

[Guest guest]

Hi Sue. By the way I couldn't open the URL's to that testing website

you mentioned...

I think, and I'm reading btw the lines, they don't like her RNA stuff.

I think they don't even believe its genuine.

>

> Hi Jill,

>

>

> Message: 25

> Date: Thu, 05 Jan 2006 21:55:19 -0000

> From: " jill1313 " <jenbooks13@h...>

> Subject: Re: Rich: Mercury, Apolipoprotein E4 Genotype...?

>

> > That's the DAN book I just read, correct?... the protocol in that

book

> > is pretty brilliant and applies to

> > all of us.

>

> Have you figured out why Amy Yasko is not mentioned in this book?

> (Maybe I just haven't gotten far enough in it?)

>

> Sue ,

> Upstate New York

>

[Guest guest]

Hi, .

Thanks for the information.

It sounds as though you've made some good choices, based on your

test results.

Rich

> > >

> > > Hi, shakerz25.

> > >

> > > The connection between apolipoprotein E4 genotype and problems

with

> > > mercury detox was new to me, but I did find the following

abstracts

>

[Guest guest]

Hi, .

O.K. on the correction.

I think the full set of Genovations characterizations are a

worthwhile investment, too, for those who can manage it. One nice

thing is that these results won't change over time, so it's an

investment that should be good for a lifetime.

It may be that it will become possible to characterize a large

number of genetic variations for a lower cost. I can't predict this

accurately, but based on the type of technology that is being used

(gene chips), I think this is a good bet. I'm hopeful that we will

see economies of the sort we have enjoyed with solid state

electronics, which has been truly mind boggling.

Rich

>

> Correction...Meant to say Genovations cardio panel shows your apoe

profile while their detox panel shows many gene variants impacting

glutathione status.

>

>

> FWIW, I think its worthwhile to get all five(last I counted) of

their SNPs(gene variant)panels. The results fit quite nicely with

the data found in the new book, Autism: Effective Biomedical

Treatments, which is fast becoming the MUST read and possible

watershed book for PWME/CFIDS/Lyme treatment in 2006.

>

>

>

[Guest guest]

Hi, Jill.

" jill1313 " <jenbooks13@h...> wrote:

That's the DAN book I just read, correct?

***Yes.

> Can you list all the tests you are recommending?

***Well, like I said, the five panels(which include many several gene variants)

from www.genovations.com. I've listed at least a few times on this list the

gene variants in which I particularly have which demonstrate predisposition to

glutathione production and metabolism issues. If you want an exhaustive list of

all the SNPs these panels reveal you could simply call them at their phone

number at their website.

I agree, the protocol in that book is pretty brilliant and applies to

> all of us. The only thing some of the autism researchers are leaving

> out a little too much imo is borrelia.

***Got it. My take is they probably see borrelia, along side many others

infections often found in Autistics, like we PWMEs, as secondary to the primary

problem of poor cellular detox/immune function caused by gene variants

predisposing this. The two Polish studies cited on this list by Rich this past

week on borrelia's impact on intracellular GPx seem to support their view and

unveil a new leaf predictable by his.

<davidhall@w...> wrote:

> >

> > Correction...Meant to say Genovations cardio panel shows your apoe

> profile while their detox panel shows many gene variants impacting

> glutathione status.

> >

> >

> > FWIW, I think its worthwhile to get all five(last I counted) of

> their SNPs(gene variant)panels. The results fit quite nicely with the

> data found in the new book, Autism: Effective Biomedical Treatments,

> which is fast becoming the MUST read and possible watershed book for

> PWME/CFIDS/Lyme treatment in 2006.

> >

> >

> >

[Guest guest]

, I hope you don't mind if you would repeat your gene variants

for me and your interpreation of them. Really sorry, but, at whatever

time you posted them I may not have been reading the list, and/or I

hadn't read the DAN book yet, which has greatly impressed me. So now I

would see them through a new lens and it would be helpful. I'll go

google genovations and see what five panels they recommend. I get to

see, after making the appointment last SEPTEMBER!, that's how long it

takes, to see an immunologist who is lyme-familiar who is on my HMO,

next week. I want to see if he can get any tests covered, if not, I'll

pay out of pocket. I'll try to make a case for these gene variants

being connected to immune function. He may be interested, I hope so, I

hear he's a good guy.

ly, tho, I know so many folks who were robustly healthy and

borrelia knocked them flat so I still think they're underestimating

borrelia. But then again, I'm 99% convinced its bioweaponized so I

have my own viewpoints . Perhaps borrelia of old, naturally

occurring, would be equivalent to other infections.

> > >

> > > Correction...Meant to say Genovations cardio panel shows your apoe

> > profile while their detox panel shows many gene variants impacting

> > glutathione status.

> > >

> > >

> > > FWIW, I think its worthwhile to get all five(last I counted) of

> > their SNPs(gene variant)panels. The results fit quite nicely with the

> > data found in the new book, Autism: Effective Biomedical Treatments,

> > which is fast becoming the MUST read and possible watershed book for

> > PWME/CFIDS/Lyme treatment in 2006.

> > >

> > >

> > >

>

[Guest guest]

What am I going to do if it is fricken ILLEGAL for me to get these

tests in NY?

Who else does these tests? Thanx.

> >

> > Correction...Meant to say Genovations cardio panel shows your apoe

> profile while their detox panel shows many gene variants impacting

> glutathione status.

> >

> >

> > FWIW, I think its worthwhile to get all five(last I counted) of

> their SNPs(gene variant)panels. The results fit quite nicely with

> the data found in the new book, Autism: Effective Biomedical

> Treatments, which is fast becoming the MUST read and possible

> watershed book for PWME/CFIDS/Lyme treatment in 2006.

> >

> >

> >

>

[Guest guest]

Hi, Jill.

I think has already responded about what Amy Yasko offers at

www.testing4health.com There is also a company called www.sciona.com

that offers genetic testing. I don't know how comprehensive it is,

compared to Genovations.

Rich

>

> What am I going to do if it is fricken ILLEGAL for me to get these

> tests in NY?

> Who else does these tests? Thanx.

>