Rich - all my results

[Guest guest]

Hi Rich

Thanks for your reply.

These are all the results. Reference range in brackets. How would I

know if the T helper were Th1 or Th2 ?

Also I have a question about Immunopro. I cant bear the taste if I

added to soya milk and had it with cereal would I still get benefit ?

I know it says tak away from food but this will be the only way I

could stand to take it.

Total WBC 4500 (4800-10800)

Total lymphocyte 1260 9960-4320)

%lymphocyte 28% 20-40%

Total Tcell 999 586-3672

T Cell T11 CD2 79 61-85%

Total T helper cell (T4) 718 (336-2376)

Total Suppressor cell 265 (192-1598

T Helper Cell T4 57.0 (35-55%)

%supressor cell 21 20-37 %

T helper/T suppressor 2.7 (1-2.5)

Total B cell 164 48-648

%B cell 13 5-15 %

%Total Natural Killer Cells 9 (5.5-20%

Total Immunocompetent 13 (14-216)

Immunocompetent NKHT3+ 1 (1.5-5 %)

Total NKHT3 Negative 1 (38-648)

NKHT3 Negative % 8 (4-15%)

Total CD3 CD26 441 10-1944

%CD3 CD26 35% 1-45%

Total T3 1034 509-3413

T3 postive cells 82 (53 - 79 %)

Total CD8 = CD11B cells 13 (48-518)

TotalCD8+ HLA DR Cells 25 0-86

%of CD8 HLA DR cElls 2 0-2%

Total CD8+ CD38 cells 38 29-302MM3

%of CD8 + CD38 cells 3% 3-7%

Total CD4 CD45 RA 202 (240-2203)

NK cell activity 7 (20-50)

IgG EBNA 316 (0-100)

[Guest guest]

Hi, .

Thanks for posting the complete results of your lymphocyte count.

It isn't possible to tell directly from these results whether the

helper-T cells are dominantly Th1 or Th2. For that, it is necessary

to look at the cytokines, which is another test offered by

Immunosciences Lab.

I think that if you added ImmunoPro Rx to soya milk and cereal that

you would still receive benefit from it, but perhaps not as much as

if you took it separately from other foods. The idea here is that

the less digestion that goes on in the stomach, the better, so that

more of the cysteine is preserved and absorbed by the small

intestine as cysteine, rather than being oxidized to cystine. But

even if some is oxidized to cystine, it can still be used by your

kidneys and recycled, even if the liver can't use it very well on

the first pass to make glutathione.

Now, here are some comments on your lymphocyte count results:

First, your total white blood cell count is low. We don't have a

complete blood count (CBC) with differential white cell counts

reported here, so we can't say what your other white blood cell

counts are (other than the lymphocyte counts). However, I suspect

from the numbers here that your neutrophil count might be a little

low, also.

A low white cell count indicates that you have a condition that

involves your immune system, since the role of the white cells is to

carry out immune responses.

Your total lymphocyte count is low normal. The lymphocytes include

primarily the T cells, the B cells and the natural killer (NK)

cells. This indicates that you have an immunodeficiency, and we

have to look further to see which subclass or subclasses might be

low.

The total T cell count is low normal. The T cells include the helper

T cells and the suppressor (or cytotoxic or killer) T cells. So we

have to look at these to see which might be low.

The total helper T cell count is low normal, and the suppressor T

cell count is low. Looking at the ratio, it is high, and that

indicates that the major factor in the above results is the low

number of suppressor T cells, though the number of helper T cells is

somewhat low as well. (The good news here is that you don't have

AIDS, which would give a low ratio instead of a high one!) The

result of a low number of suppressor T cells would be that your

immune system would not be able to fight viral infections as well as

normal, since that's the main role of the suppressor T cells. The

result of a somewhat low number of helper T cells is that your

immune system would probably not be able to fight intracellular

bacteria infections (such as by chlamydia, mycoplasma or rickettsia

bacteria) as well as normal, and would also probably not be able to

make antibodies as well as normal.

Your B cell count is low normal. This means that your immune system

would not be able to produce antibodies to infectious agents as well

as normal.

It appears that your helper T cells are somewhat activated, while

your suppressor T cells and your natural killer cells are not

activated. The fraction of natural killer cells that are

immunocompetent, as well as their activity, is low. This means that

your helper T cells are " aware " that you have one or more

infections, but that your killer-T cells and your natural killer

cells don't seem to have " gotten the word. "

The expression of MHC Class II antigens on your lymphocytes is

somewhat elevated. This may mean that you have some intracellular

bacterial infection, because that's what these antigens are used to

signal.

You have an elevated IgG antibody titer to the Epstein--Barr Virus

nuclear antigen. Since the other Epstein--Barr antibodies were not

reported, we can't say for sure whether that means a reactivated

Epstein-Barr infection or a new one, but I suspect it's a

reactivated one, based on other CFS cases.

Your test results correspond fairly well with what has been reported

in PWCs in the past, as summarized by Klimas and her group.

It's also interesting to note that they correspond well with the

recently reported gene expression results from Kerr's group and from

Gow's group. I'm thinking particularly of indications of immune

system activation and elevation of MHC Class II.

So in summary, I would say that these results indicate that you have

an immune dysfunction that is characteristic of chronic fatigue

syndrome. Your immune system is not able to fight viral infections

or intracellular bacterial infections well. You probably have a

reactivated Epstein--Barr viral infection, and you may also have

other infections.

The CFS research and treatment community does not know what causes

this immune dysfunction in CFS. Various measures have been tried

for treating it, such as immune modulators or immune stimulators.

These have included things like Immunovir (isoprinosine),

kutapressin (now Nexavir), pinextra, MGN-3 (taken off the market by

the FDA in 2004 because of marketing claims, not because of proven

ineffectiveness), ProBoost thymic protein A, and transfer factors,

with some success.

In my own opinion, for what it's worth, the immediate cause of both

the immune dysfunction and of the viral reactivation in CFS is

depletion of glutathione, as I have discussed on pages 12 and 13 of

my poster paper, which can be found at

http://www.cfsresearch.org/cfs/research/treatment/15.htm

I have discussed methods of raising glutathione, and this can be

found at

http://phoenix-cfs.org/Glutathione%20Building%20in%20CFS.htm

Some PWCs have been able to raise their glutathione using one or

more of these methods, but some have not. In the latter cases, I

have come to suspect that the reasons are primarily partial

blockades in the methylation cycle and buildup of mercury, as has

been found in many cases of autism. Accordingly, for the past two

months I have been suggesting that PWCs who have difficulty building

up their glutathione consider the treatments being used by the DAN!

project doctors in treating autism. These are described in videoed

talks at the following website: http://www.danwebcast.com (I'm

referring to the spring 2005 meeting of DAN! in Boston), and they

are also described in more detail in a new book by Pangborn and

Baker called " Autism: Effective Biomedical Treatments, " which is

available from http://www.autismresearchinstitute.com for 30 U.S.

dollars.

I hope this is helpful.

Rich

>

> Hi Rich

> Thanks for your reply.

> These are all the results. Reference range in brackets. How would

I

> know if the T helper were Th1 or Th2 ?

>

> Also I have a question about Immunopro. I cant bear the taste if I

> added to soya milk and had it with cereal would I still get

benefit ?

> I know it says tak away from food but this will be the only way I

> could stand to take it.

>

>

> Total WBC 4500 (4800-10800)

> Total lymphocyte 1260 9960-4320)

> %lymphocyte 28% 20-40%

> Total Tcell 999 586-3672

> T Cell T11 CD2 79 61-85%

> Total T helper cell (T4) 718 (336-2376)

> Total Suppressor cell 265 (192-1598

> T Helper Cell T4 57.0 (35-55%)

> %supressor cell 21 20-37 %

> T helper/T suppressor 2.7 (1-2.5)

> Total B cell 164 48-648

> %B cell 13 5-15 %

> %Total Natural Killer Cells 9 (5.5-20%

> Total Immunocompetent 13 (14-216)

> Immunocompetent NKHT3+ 1 (1.5-5 %)

> Total NKHT3 Negative 1 (38-648)

> NKHT3 Negative % 8 (4-15%)

> Total CD3 CD26 441 10-1944

> %CD3 CD26 35% 1-45%

> Total T3 1034 509-3413

> T3 postive cells 82 (53 - 79 %)

> Total CD8 = CD11B cells 13 (48-518)

> TotalCD8+ HLA DR Cells 25 0-86

> %of CD8 HLA DR cElls 2 0-2%

> Total CD8+ CD38 cells 38 29-302MM3

> %of CD8 + CD38 cells 3% 3-7%

> Total CD4 CD45 RA 202 (240-2203)

> NK cell activity 7 (20-50)

> IgG EBNA 316 (0-100)

>