methylation treatment

[Guest guest]

The DAN! recommended treatment for both high homocysteine and low homocysteine

is the same: on the one hand, methylB12, possibly DMG and folinic acid all

help catalyze the conversion of homocysteine to methionine, and on the other

hand vitamin B6/P5P catalyzes the conversion of homocysteine to

cystathionine.

I and somebody else on the list wondered why these same treatments are

recommended for both low and high homocysteine.

The answer, from " Autism: Effective Biomedical Treatments " , actually makes a

lot of sense:

If you have high homocysteine, you want to get rid of it, so you help catalyze

its conversion to cysteine and methionine.

But the reaction that converts SAH (homocysteine's predecessor in the

methionine cycle) to homocysteine is reversible whereas the conversion of

homocysteine to methionine or cysteine is not.. So, if you have low

homocysteine, you might have a buildup at SAH, which in turn blocks the whole

cycle. By helping remove homocysteine from the cycle, you set the conditions

for converting more SAH to homocysteine, thus lowering SAH and getting your

whole cycle moving again.

Or at least, so goes the theory.

[Guest guest]

Hi, cb122.

The simplified treatment approach for lifting the partial methylation cycle

block was developed to lower the cost and complexity of the full Yasko treatment

program. It works for most PWCs/PWMEs, but not for all. I recommend trying it

for 3 months, and if benefits are not experienced by then, it is time to

consider a change in protocol or more testing to see what is going on.

MethylMate A is a combined supplement. The most important parts are included in

the simplified treatment. Some people do not do well on combined supplements

because they have a sensitivity to one constituent or another, so I have favored

using single supplements where possible, though I have still included the multi

developed by Yasko to cover deficiencies in vitamins and minerals, as well as to

provide certain other nutrients that are helpful for the methylation cycle and

related pathways. Some people are sensitive to one or more of the ingredients,

and have had to try other multis, such as the Thorne Basic.

Best regards,

Rich

> > >

> > > Hi I didn't do very well on Questran (cholestyramine) I tried one sachet a

day for a month and it just seemed to clog up my system (not bowel wise as I

took plenty of vit C) but I just felt very toxic and nauseas. Iv been off it for

2weeks and trying to build up my stamina levels again. I will try very low doses

of the methylation protocol i.e. ActiFolate and Intrinsic B12/Folate which

appear to be the key supplements then add the rest as I go along given that I

don't suffer too much from the first two supplements.

> > >

> > > Regards

> > > Gordon

> > > U.K.

> > >

> > > (a bit wind blown today from hurricane Collete you sent over from the

states)

> > > methylation treatment

> > >

> > >

> > >

> > > Hi Gordon,

> > >

> > > How did your trial of cholestyramine go?

> > >

> > > I have a friend in California who is on the RVK methylation protocol.

She says she has seen significant improvement.

> > >

> > > Tim

> > >

> > > Hi All ....I tend to come here to share experiences and ideas for those

looking for a treatment in to their cause of CFS/ME symptoms.

> > >

> > > Has anyone tried the Rich Van Konynenburge treatment plan out for

methylation cycle block?

> > >

> > > http://aboutmecfs.org.violet.arvixe.com/Trt/TrtGSHMethISimple.aspx

> > >

> > > http://www.drmyhill.co.uk/wiki/CFS_-_The_Methylation_Cycle

> > >

> > > It would be useful to share experiences from those who have tried this

or hear from those keeping a log when trying this protocol.

> > >

> > > Regards

> > > Gordon

> > > Leeds

> > > U.K.

> > >

> > >

> > >

> > >

> > >

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> > >