Re: Aposhian 2003 paper on mercury detox

[Guest guest]

Rich,

thanks so much for all this information. But it just about brings me to tears to

know there is no way at this point to get the merc out of the brain :-( I'm

glad good minds are working on it, but its all very depressing when you know you

are loaded with merc.

Marcia

Aposhian 2003 paper on mercury detox

Hi, all.

I've now had a chance to read the paper by Aposhian on mercury detox

that I mentioned previously. I'd like to summarize it here, because

I think it bears on much of our recent discussion of mercury detox.

Here's the reference:

Aposhian, H.V. et al., " Vitamin C, glutathione, or lipoic acid did

not decrease brain or kidney mercury in rats exposed to mercury

vapor, " Journal of Toxicology: Clinical Toxicology 41.4 (June

2003):339(9).

First, a few preliminary comments. The major source of mercury

exposure for the general population has been elemental mercury from

dental amalgams, and this is well-documented. The work reported in

this paper involved this type of mercury, not organic forms such as

methylmercury, which comes from eating fish, or ethylmercury, which

comes from getting vaccinations with vaccines that contain the

preservative thimerosol.

Second, this study was done on rats, not humans. It isn't known

what the differences may be between rats and humans in regard to

absorption and detox of elemental mercury. Obviously, there would

be serious ethical issues involved in doing studies of this type on

humans, so we will have to settle with studies on rats (or other lab

animals) and try to extrapolate to humans.

Third, the main target organs for mercury in the body are the

kidneys and the brain. This is true in both rats and humans.

With those things being understood up front, here's what was done:

Young rats were exposed to elemental mercury vapor by inhalation,

two hours per day for seven consecutive days. There was also a

control group that was exposed only to air. Then there was a seven-

day waiting period. Then DMPS, DMSA, glutathione, vitamin C, or

lipoic acid, both alone and in combination were administered for

seven days. N-acetylcysteine was administered alone. There was

also an additional control group that was not treated to remove

mercury. Then the rats were killed, and their brain and kidneys

were removed and analyzed for mercury.

Here are the results:

None of the various treatment regimens decreased the mercury content

of the brain. That included the DMPS and the DMSA as well as the

others.

DMPS and DMSA were each effective in decreasing the mercury content

of the kidneys, but glutathione, vitamin C and lipoic acid alone had

no such activity, nor did they enhance the activity of DMPS or DMSA

when used together with either of them.

N-acetylcysteine was found not to decrease the mercury content of

the kidneys, and it actually increased the mercury content of the

brain.

What do these results mean, if we assume that they would be the same

in humans? I think they mean that although glutathione is effective

in conjugating with mercury as it enters the body, and is normally

used then to carry mercury out of the body, it is not effective in

removing mercury that has become bound in body tissues, including

both the kidneys and the brain. Similarly, vitamin C, alpha lipoic

acid, and N-acetylcysteine are not effective in removing mercury

that has become bound in body tissues, and N-acetylcysteine even

appears to move more into the brain.

Of those tested, the only agents that were found to be effective in

removing mercury bound in tissues were the chelators DMPS and DMSA,

and even these were not able to remove mercury from the brain.

Presumably, the reason DMPS and DMSA were able to remove mercury

from the kidneys while the others were not is that they are true

chelators, capable of forming two bonds to mercury ions, and thus

exhibit stronger bonding than the bonding to single sulfur atoms,

which holds the mercuric ions in the tissue.

Presumably, the reason DMPS and DMSA were not able to remove mercury

from the brain, while they could do so from the kidneys, was that

they could not cross the blood-brain barrier.

In light of this study, is there value in building up glutathione

levels in the body before using one of the chelating agents, DMPS or

DMSA? I still think that the answer is yes. It is known that even

though the chelators bind strongly to mercury, they are not perfect

bonding agents, and some mercury ions will come loose from them and

be redistributed in the body. I think there is value in having the

glutathione in place to intercept this released mercury and carry it

out, even though this study did not show a statistically significant

effect of adding glutathione to either of these agents. I think it

should be borne in mind that this study used healthy young rats that

presumably had normal glutathione levels to start with. A PWC may

not be in this condition, and I suspect that most are not. So I do

think that building up glutathione before chelating is a good idea.

Can this be done? Apparently it can. In the past, I was concerned

that the presence of mercury might prevent the formation of

glutathione in the body, since it is known that mercury will block

at least three of the enzymes in the glutathione system at high

enough concentration. However, there have been a small number of

people now who have reported that they were able to build their

glutathione even though they had significant amounts of mercury in

their bodies. And it may be that others will be able to do it as

well, if they take measures to improve the operation of their

methylation cycle first, i.e., taurine, methyl B12, perhaps adding

folinic acid, perhaps adding TMG or DMG, perhaps adding vitamin B6

or its active form, pyridoxal-5-phosphate.

So what about the brain? Are we ever going to be able to get the

mercury back out of it? Right now, I don't think anybody has a

proven way to do that. Quig told me that he hopes that a

combination of alpha lipoic acid and DMSA will eventually do it, but

it didn't prove to do it in this short-duration study on rats.

I should mention the possibility that PWCs may have leaky blood-

brain barriers (as hypothesized a few years ago by Bested et al.),

so that maybe the chelating agents could get into the brains of

PWCs. I don't think we can rely on this possibility, though.

Some of you may remember that a long time ago I suggested the

possibility that vitamin B12 in large dosages might be able to

methylate mercuric mercury that is bound in the brain and thus

facilitate its movement back out of the brain, since methymercury is

known to cross the blood-brain barrier easily. Methyl-B12 is the

only substance in biological systems that can give a methyl group to

a mercuric ion, because it is the only methylator that can donate a

negatively charged methyl group (carbanion). This is necessary,

because the mercury ion is positively charged, +2, and the stable

product, methylmercury ion, has a +1 charge. (Methyl-B12 the same

thing that bacteria use to methylate mercury, presumably to protect

themselves, but it gets into fish and then causes humans a lot of

problems.) Well, anyway, I dusted this idea off and sent it to the

guys who are looking for better detoxers for mercury in autistic

kids, along with supporting papers showing that the reaction will go

nonenzymatically, as well as enzymatically like the bacteria do it,

and that giving high-dose B12 to guinea pigs was found to increase

their methyl mercury concentrations. That was last week. I'm

waiting to find out what they think about it. I think it's a

question of whether one could achieve a high enough concentration of

methyl-B12 in the brain to pull this off, before it became toxic for

some reason. B12 has a pretty low toxicity, though, so maybe it

would actually work. Of course, it would be very important to clear

the mercury out of the rest of the body using the chelators before

one loaded up on methyl B12, or it would move more methylmercury

into the brain, as it was found to do in the guinea pigs. That we

don't need!

The other possibility for dealing with mercury that won't come out

is to " neutralize " it in place with selenium. Selenium binds to

mercury more strongly than either individual sulfur atoms or

chelators that can form two bonds. It has been found that the the

mercury and selenium bind together to form little crystallites of

the natural mineral tiemannite, which chemically is mercuric

selenide, with a one-to-one atomic ratio of mercury to selenium. It

apparently isn't known, though, whether these could cause problems

over the long term, so no reputable expert is recommending this

approach right now, as far as I know. I do think it's something to

keep in mind, though, especially if we can't figure out any way to

get the mercury out of the brain. I'm going to pursue the methyl-

B12 route first, though.

Right now I wouldn't recommend that anyone try either of these

approaches, because they are unproven and may end up causing more

problems than they solve, but I just want you to know that somebody

is working on this problem.

Rich

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Hi Rich,

Thank you for your summary of the article.

Do you know which are the three enzymes that are influenced and/or damaged by

Hg?

Thanks for everything,

Sue T

rvankonynen <richvank@...> wrote:

In the past, I was concerned

that the presence of mercury might prevent the formation of

glutathione in the body, since it is known that mercury will block

at least three of the enzymes in the glutathione system at high

enough concentration.

[Guest guest]

Hi, Sue.

Yes, they are glutamate-cysteine ligase (formerly known as

gammaglutamylcysteine synthestase), glutathione reductase, and

glutathione peroxidase. Those are the ones I know of from reading

the research literature. I think there are others in the

methylation cycle that are affected as well, as well as others in

different parts of the overall body's metabolism. Mercury binds to

sulfhydryl groups, which are found in any enzyme or other protein

that incorporates cysteine as part of its structure. If, as is

often the case, the cysteine residue is located at the catalytic

center of the enzyme and is important to its function, then bound

mercury can interfere with its operation.

Rich

> In the past, I was concerned

> that the presence of mercury might prevent the formation of

> glutathione in the body, since it is known that mercury will block

> at least three of the enzymes in the glutathione system at high

> enough concentration.

>

>

[Guest guest]

Hi, Marcia.

Yeah, I'm sorry about that, but the game isn't over yet. It might be

encouraging to you to know that the whales and other marine mammals,

as well as some of the fish and the sea birds are able to store very

large quantities of mercury in their bodies as mercuric selenide, and

they apparently don't experience toxic effect from the mercury when

it's in this form. Fortunately for them, selenium is abundant in

their food sources, so they take it in and use it to compensate for

the methylmercury that they ingest, also in their food. Do you get

the idea that somebody up there who knows his chemistry was looking

out for these guys? Otherwise, this seems like a very strange

coincidence.

Rich

>

> Rich,

>

> thanks so much for all this information. But it just about brings me

to tears to know there is no way at this point to get the merc out of

the brain :-( I'm glad good minds are working on it, but its all very

depressing when you know you are loaded with merc.

>

> Marcia

[Guest guest]

> it just about brings me to tears to know there is no way at this

> point to get the merc out of the brain :-(

Hi Marcia -

I have to respond to this. My own experience says there is hope,

despite the data of this recent report. As I've said before, my brain

fog cleared the day the last (in my case, all) of my mercury amalgams

were removed.

In the 20 months since then, cognitive function has been slowly

returning:

* I can crochet and knit again, and am getting better at counted

cross-stitch (need cheater marking threads every 10 squares instead

of every 5; never needed any before I got sick)

* Last month I memorized a Chopin Nocturne (though even short Bach

Fugues still won't stick)

* I can now occasionally plan and make a real meal (multiple items

that I prepare, ready at the same time)

* I can do 3 or even more things some days now without getting

confused.

There's still some cognitive function missing. But it does keep

improving - while I was chelating, and since I took a break from

chelating. The tests of this report make this seem unlikely if not

impossible. But it's happening.

On a different note, I've been concerned about your upcoming DMPS

challenge, though I know you've been preparing your body well for it.

(I didn't prepare for mine at all, not expecting to find a metal

problem of any kind.)

One thing: Fiber. You probably know it's important that bowel transit

time be less than 14 hours. (Some of the mercury will be routed

through the colon; anything left there more than 14 hours gets

reabsorbed into the body and redistributed.) I didn't try my fiber

product first. It stopped everything for 36 hours after the test. No

doubt this contributed to my later bad reaction.

So I heartily recommend you figure out what type of fiber or whatever

you'll use, and try it ahead of time to be sure it will work in

*your* body as expected.

Good luck! -Lynn K

[Guest guest]

>

> Hi, all.

>

> I've now had a chance to read the paper by Aposhian on mercury

detox

> that I mentioned previously. I'd like to summarize it here,

because

> I think it bears on much of our recent discussion of mercury detox.

>

> Here's the reference:

>

> Aposhian, H.V. et al., " Vitamin C, glutathione, or lipoic acid did

> not decrease brain or kidney mercury in rats exposed to mercury

> vapor, " Journal of Toxicology: Clinical Toxicology 41.4 (June

> 2003):339(9).

>

> First, a few preliminary comments. The major source of mercury

> exposure for the general population has been elemental mercury

from

> dental amalgams, and this is well-documented. The work reported

in

> this paper involved this type of mercury, not organic forms such

as

> methylmercury, which comes from eating fish, or ethylmercury,

which

> comes from getting vaccinations with vaccines that contain the

> preservative thimerosol.

>

> Second, this study was done on rats, not humans. It isn't known

> what the differences may be between rats and humans in regard to

> absorption and detox of elemental mercury. Obviously, there would

> be serious ethical issues involved in doing studies of this type

on

> humans, so we will have to settle with studies on rats (or other

lab

> animals) and try to extrapolate to humans.

>

> Third, the main target organs for mercury in the body are the

> kidneys and the brain. This is true in both rats and humans.

>

> With those things being understood up front, here's what was done:

>

> Young rats were exposed to elemental mercury vapor by inhalation,

> two hours per day for seven consecutive days. There was also a

> control group that was exposed only to air. Then there was a

seven-

> day waiting period. Then DMPS, DMSA, glutathione, vitamin C, or

> lipoic acid, both alone and in combination were administered for

> seven days. N-acetylcysteine was administered alone. There was

> also an additional control group that was not treated to remove

> mercury. Then the rats were killed, and their brain and kidneys

> were removed and analyzed for mercury.

>

> Here are the results:

>

> None of the various treatment regimens decreased the mercury

content

> of the brain. That included the DMPS and the DMSA as well as the

> others.

>

> DMPS and DMSA were each effective in decreasing the mercury

content

> of the kidneys, but glutathione, vitamin C and lipoic acid alone

had

> no such activity, nor did they enhance the activity of DMPS or

DMSA

> when used together with either of them.

>

> N-acetylcysteine was found not to decrease the mercury content of

> the kidneys, and it actually increased the mercury content of the

> brain.

>

>

> What do these results mean, if we assume that they would be the

same

> in humans? I think they mean that although glutathione is

effective

> in conjugating with mercury as it enters the body, and is normally

> used then to carry mercury out of the body, it is not effective in

> removing mercury that has become bound in body tissues, including

> both the kidneys and the brain. Similarly, vitamin C, alpha

lipoic

> acid, and N-acetylcysteine are not effective in removing mercury

> that has become bound in body tissues, and N-acetylcysteine even

> appears to move more into the brain.

>

> Of those tested, the only agents that were found to be effective

in

> removing mercury bound in tissues were the chelators DMPS and

DMSA,

> and even these were not able to remove mercury from the brain.

>

> Presumably, the reason DMPS and DMSA were able to remove mercury

> from the kidneys while the others were not is that they are true

> chelators, capable of forming two bonds to mercury ions, and thus

> exhibit stronger bonding than the bonding to single sulfur atoms,

> which holds the mercuric ions in the tissue.

>

> Presumably, the reason DMPS and DMSA were not able to remove

mercury

> from the brain, while they could do so from the kidneys, was that

> they could not cross the blood-brain barrier.

>

> In light of this study, is there value in building up glutathione

> levels in the body before using one of the chelating agents, DMPS

or

> DMSA? I still think that the answer is yes. It is known that

even

> though the chelators bind strongly to mercury, they are not

perfect

> bonding agents, and some mercury ions will come loose from them

and

> be redistributed in the body. I think there is value in having

the

> glutathione in place to intercept this released mercury and carry

it

> out, even though this study did not show a statistically

significant

> effect of adding glutathione to either of these agents. I think

it

> should be borne in mind that this study used healthy young rats

that

> presumably had normal glutathione levels to start with. A PWC may

> not be in this condition, and I suspect that most are not. So I do

> think that building up glutathione before chelating is a good

idea.

>

> Can this be done? Apparently it can. In the past, I was

concerned

> that the presence of mercury might prevent the formation of

> glutathione in the body, since it is known that mercury will block

> at least three of the enzymes in the glutathione system at high

> enough concentration. However, there have been a small number of

> people now who have reported that they were able to build their

> glutathione even though they had significant amounts of mercury in

> their bodies. And it may be that others will be able to do it as

> well, if they take measures to improve the operation of their

> methylation cycle first, i.e., taurine, methyl B12, perhaps adding

> folinic acid, perhaps adding TMG or DMG, perhaps adding vitamin B6

> or its active form, pyridoxal-5-phosphate.

>

> So what about the brain? Are we ever going to be able to get the

> mercury back out of it? Right now, I don't think anybody has a

> proven way to do that. Quig told me that he hopes that a

> combination of alpha lipoic acid and DMSA will eventually do it,

but

> it didn't prove to do it in this short-duration study on rats.

>

> I should mention the possibility that PWCs may have leaky blood-

> brain barriers (as hypothesized a few years ago by Bested et al.),

> so that maybe the chelating agents could get into the brains of

> PWCs. I don't think we can rely on this possibility, though.

>

> Some of you may remember that a long time ago I suggested the

> possibility that vitamin B12 in large dosages might be able to

> methylate mercuric mercury that is bound in the brain and thus

> facilitate its movement back out of the brain, since methymercury

is

> known to cross the blood-brain barrier easily. Methyl-B12 is the

> only substance in biological systems that can give a methyl group

to

> a mercuric ion, because it is the only methylator that can donate

a

> negatively charged methyl group (carbanion). This is necessary,

> because the mercury ion is positively charged, +2, and the stable

> product, methylmercury ion, has a +1 charge. (Methyl-B12 the same

> thing that bacteria use to methylate mercury, presumably to

protect

> themselves, but it gets into fish and then causes humans a lot of

> problems.) Well, anyway, I dusted this idea off and sent it to

the

> guys who are looking for better detoxers for mercury in autistic

> kids, along with supporting papers showing that the reaction will

go

> nonenzymatically, as well as enzymatically like the bacteria do

it,

> and that giving high-dose B12 to guinea pigs was found to increase

> their methyl mercury concentrations. That was last week. I'm

> waiting to find out what they think about it. I think it's a

> question of whether one could achieve a high enough concentration

of

> methyl-B12 in the brain to pull this off, before it became toxic

for

> some reason. B12 has a pretty low toxicity, though, so maybe it

> would actually work. Of course, it would be very important to

clear

> the mercury out of the rest of the body using the chelators before

> one loaded up on methyl B12, or it would move more methylmercury

> into the brain, as it was found to do in the guinea pigs. That we

> don't need!

>

> The other possibility for dealing with mercury that won't come out

> is to " neutralize " it in place with selenium. Selenium binds to

> mercury more strongly than either individual sulfur atoms or

> chelators that can form two bonds. It has been found that the the

> mercury and selenium bind together to form little crystallites of

> the natural mineral tiemannite, which chemically is mercuric

> selenide, with a one-to-one atomic ratio of mercury to selenium.

It

> apparently isn't known, though, whether these could cause problems

> over the long term, so no reputable expert is recommending this

> approach right now, as far as I know. I do think it's something

to

> keep in mind, though, especially if we can't figure out any way to

> get the mercury out of the brain. I'm going to pursue the methyl-

> B12 route first, though.

>

> Right now I wouldn't recommend that anyone try either of these

> approaches, because they are unproven and may end up causing more

> problems than they solve, but I just want you to know that

somebody

> is working on this problem.

>

> Rich

Thanks so much Rich for this very important information. As you

know I used ALA used for nearly a year in rounds but didn't get rid

of my mercury problem. However I seem to remember that in the

Alternative Medicine Review (2001) they posted a study that showed

that ALA did move mercury out of the brain but they had concerns

because the author believed there was a real danger of it being

redistributed.

Do you know about this study, otherwise I might be able to find its

details somewhere?

BTW I am about 5 days into using NDF, 5 drops x 2 without any

problems at all so far but I have to be a bit careful because the

stuff I am using is a bit out of date so it might have lost its

ability to chelate mercury. Soon I will be onto the new bottle and

will drop the dose to start off with in case it is going to mobilise

too much mercury. My sauna should be here in a couple of days so

looking forward to some sweating too.

I am still doing all the supplements from the Sinatra protocol with

great benefits, together with the nebulising of the magnesium.

Haven't felt so well for many years but can still feel great

problems with my legs getting sufficient energy especially now it

has turned so much colder here in the UK. They keep going stone,

icy, cold even though the rest of me is really warm. If I overdo it

the problem is a lot worse. I can definitely say that these

supplements do seem to stop a crash because I have really pushed

myself physically recently because of circustances outside of my

control and although I do get some neuro symptoms they always seem

to be gone by the next day. I have also noticed that if I wake with

a headache by the time I have eaten and done 15 minutes of

nebulising the magnesium often it just goes away instead of turning

into a horrible migraine. This is something that has never happened

before so I am really encouraged.

Best Wishes

Pam

[Guest guest]

Hi, Pam.

> I am still doing all the supplements from the Sinatra protocol with

> great benefits, together with the nebulising of the magnesium.

> Haven't felt so well for many years but can still feel great

> problems with my legs getting sufficient energy especially now it

> has turned so much colder here in the UK. They keep going stone,

> icy, cold even though the rest of me is really warm. If I overdo it

> the problem is a lot worse. I can definitely say that these

> supplements do seem to stop a crash because I have really pushed

> myself physically recently because of circustances outside of my

> control and although I do get some neuro symptoms they always seem

> to be gone by the next day. I have also noticed that if I wake with

> a headache by the time I have eaten and done 15 minutes of

> nebulising the magnesium often it just goes away instead of turning

> into a horrible migraine. This is something that has never happened

> before so I am really encouraged.

Here's an abstract that might help to explain why you've gotten some

of the benefits you have from the magnesium. You might think about

trying some taurine and fish oil (make sure it's mercury free!) also:

Med Hypotheses. 1996 Dec;47(6):461-6.

Magnesium taurate and fish oil for prevention of migraine.

McCarty MF.

Nutrition 21, San Diego, CA 92109, USA.

Although the pathogenesis of migraine is still poorly understood,

various clinical investigations, as well as consideration of the

characteristic activities of the wide range of drugs known to reduce

migraine incidence, suggest that such phenomena as neuronal

hyperexcitation, cortical spreading depression, vasospasm, platelet

activation and sympathetic hyperactivity often play a part in this

syndrome. Increased tissue levels of taurine, as well as increased

extracellular magnesium, could be expected to dampen neuronal

hyperexcitation, counteract vasospasm, increase tolerance to focal

hypoxia and stabilize platelets; taurine may also lessen sympathetic

outflow. Thus it is reasonable to speculate that supplemental

magnesium taurate will have preventive value in the treatment of

migraine. Fish oil, owing to its platelet-stabilizing and

antivasospastic actions, may also be useful in this regard, as

suggested by a few clinical reports. Although many drugs have value

for migraine prophylaxis, the two nutritional measures suggested here

may have particular merit owing to the versatility of their actions,

their safety and lack of side-effects and their long-term favorable

impact on vascular health.

Publication Types:

* Review

* Review, Tutorial

PMID: 8961243 [PubMed - indexed for MEDLINE]

Take care,

MarkM

[Guest guest]

I have to respond to this. My own experience says there is hope,

despite the data of this recent report. As I've said before, my brain

fog cleared the day the last (in my case, all) of my mercury amalgams

were removed.

Hi Lynn,

thanks for sharing that, I'm getting very nervous about all of this, and

discouraged with some of the new information. I'm glad to hear about the

experience of others!

In the 20 months since then, cognitive function has been slowly

returning:

* I can crochet and knit again, and am getting better at counted

cross-stitch (need cheater marking threads every 10 squares instead

of every 5; never needed any before I got sick)

* Last month I memorized a Chopin Nocturne (though even short Bach

Fugues still won't stick)

* I can now occasionally plan and make a real meal (multiple items

that I prepare, ready at the same time)

* I can do 3 or even more things some days now without getting

confused.

Wow, being able to memorize anything would be wonderful!!! Its been so long

since I could do anything like that! Good for you, glad to hear of your

progress.

There's still some cognitive function missing. But it does keep

improving - while I was chelating, and since I took a break from

chelating. The tests of this report make this seem unlikely if not

impossible. But it's happening.

thats encouraging so thanks for sharing.

On a different note, I've been concerned about your upcoming DMPS

challenge, though I know you've been preparing your body well for it.

(I didn't prepare for mine at all, not expecting to find a metal

problem of any kind.)

yes, I've tried to prepare but it still scares me :-(

One thing: Fiber. You probably know it's important that bowel transit

time be less than 14 hours. (Some of the mercury will be routed

through the colon; anything left there more than 14 hours gets

reabsorbed into the body and redistributed.) I didn't try my fiber

product first. It stopped everything for 36 hours after the test. No

doubt this contributed to my later bad reaction.

Oh WOW, that is GOOD to know, thankyou! I will work on that before starting the

test then, I had not even thought of that. What about activated charcoal after

the urine collection part is done? Wonder if that would help too?

So I heartily recommend you figure out what type of fiber or whatever

you'll use, and try it ahead of time to be sure it will work in

*your* body as expected.

I will do that, thanks Lynn, I think you really helped me there!

Marcia

[Guest guest]

>

> Hi, all.

>

> I've now had a chance to read the paper by Aposhian on mercury detox

> that I mentioned previously.

Rich, I have lived with CFS since 1975. After my divorce in 2000 and I

moved into the trailer, I actually improved and I think not having so

much stress helped. However as you know that past two years I have

developed neurological problems which have become very bad however an

MRI didn't show anything. I returned to Van Horn, Tx today which is

where I first started to improve while living in a tent here. I feel

better already. Several things you said scared me. Now I only have two

fillings and both of those came about the year 2,000. As you know I do

take high doses of B-12 and according to what you said, that could

move mercury to the brain. I also took the other supplements you

mentioned which I think you said could do the same thing. I cannot

help but to wonder if these things caused the onset of the

neurological problems?

I know you are not an MD but I am thinking that I shouldn't continue B-

12 for now and what is you opinion? Maybe I should discontinue all

supplements for awhile since I am doing worse instead of better.

Bob