Abolishing Brain Microvascular Inflammation/Telmisartan?

[Guest guest]

Hi, All.

I saw this abstract from the Journal of Cerebral Blood Flow & Metabolism -

Abstract of article: Angiotensin II AT1 receptor blockade abolishes brain

microvascular inflammation and heat shock protein responses in hypertensive rats

Address:http://www.nature.com/jcbfm/journal/v25/n7/abs/9600082a.html

This paper is interesting in view of Rich's glutatione depletion hypothesis for

PWCs, the four papers he noted recently that showed angiotensin receptor

blockers(ARBs) leading to increased glutathione levels in vivo and Dr Cheney's

recent thoughts on CFS via Carol S.'s transcripts that indicate among four major

organ systems (kidneys, lungs, heart and brain) that the brain is the most

vulnerable among the four to breakdowns or weakening in its own

renin-angiotensin-system(RAS) blood flow.

This study found its results through the use of an ARB in hypertensive

situations, but I wonder if some of the same underpinning processes occurring in

hypertension might just as well be the same in CFS, though most PWCs bodies may

be compensating with abnormally low blood pressure. Also, one of Ken L's

alternative suggestions to the main constituent of " the benicar protocol " ,

namely benicar, is telmisartan.

Telmisartan is an ARB said to be able to cross the blood brain barrier where

benicar cannot. Has anyone on this list tried Telmisartan or do you know anyone

elsewhere with a CFS or Lyme diagnosis who has or is doing so?

It seems using Telmisartan for its anti-inflammatory potential in the brain, in

particular, combined with an explicit glutathione building product might be

worth doing.