AD Hock and Vitamin D

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Always open for discussion -- I'm a **modeller** so I have no

personal investment, rather prefer to improve the model... :-)

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" 4 case reports by A.D.Hock (Germany) brought up the possibility that

Vitamin D and parathormone disturbance should not be overlooked as a

possible cause of chronic fatigue. The symptoms are very similar and

this is a treatable disorder. "

Source: http://www.cfsresearch.org/cfs/conferences/2nf.htm (Second

World Congress on Chronic Fatigue Syndrome and Related Disorders)

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Hack AD. Divalent Cations, Hormones, Psyche and Soma: Four Case

Reports Journal of Chronic Fatigue Syndrome 2000; 6(3/4): 117

" Objectives: The steroid hormone, vitamin D and the peptide hormone,

parathormone are reported to influence not only bone metabolism, but

also other metabolic and nervous, cardiovascular and immune

functions, and mood. Regular actions of these hormones depend highly

on intracellular magnesium content. Although symptoms are recognized,

they usually are not correlated to these hormones. Foregoing case

studies have revealed that vitamin D and/or parathormone disorders

are common causes of CFS-fibromyalgia like symptoms. Methods: Four

patients with chronic fatigue-like symptoms and vitamin D (25OHD3)

and parathormone (PTH intact) disorders are illustrated to

demonstrate conflicting laboratory results. Patients were treated

with 5,000 to 10,000 IU cholecalciferol, plus multiminerals and trace

elements. Clinical outcome was assessed and treatment difficulties

are reported.

Results: Diagnostic pitfalls are shown. Vitamin D and parathormone

disorders are not completely detectable by calcium and phosphate

screening. In 2 of this 4 demonstrated cases treatable diagnosis

would have been missed without endocrinological screening. In the

case of undetected long-standing disorder of these hormones,

intracellular mineral derangement follows, thus inducing vitamin D

resistance and parathormone ineffectiveness which makes therapy

difficult. Combining vitamin D therapy with multiminerals possibly

may overcome these obstacles.

Conclusions: Vitamin D and parathormone disturbance should not be

overlooked in chronic fatigue. Appropriate therapy is easy,

inexpensive and harmless. Early diagnosis and treatment might be

essential to avoid chronic fatigue syndrome. The complexity of

diagnosis, therapy and scientific background may lead to a new

understanding of ``psycho-somatic'' disease. The relation between

intracellular minerals, trace elements, cellular energy supply and

responsible hormones should become clearer. "

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Hock, AD. Fatigue and 25-hydroxyvitamin D levels. Journal of Chronic

Fatigue Syndrome, 1997, 3, 3, 117-127.

This article describes 504 fatigued patients, of whom all but eleven

had low levels of 25-hydroxyvitamin D. They were treated using

appropriate doses of cholecalciferol.

There was an excellent response in those with a mild deficiency, but

a more variable outcome for patients with extremely low levels and/or

chronic ill health.

The author suggests that measurements of vitamin D should be included

in the screening of patients with fatigue.

http://freespace.virgin.net/david.axford/mecap97.htm

> <>Hi Ken,

>

>

> Thankyou for the pages. I have found them very useful. Would you be

> interested in some constructive criticism/discussion on a few

points?

>

> Also do you happen to have a copy of the paper:

>

> Hock, AD. *_Fatigue and 25-hydroxyvitamin D levels_*. Journal of

Chronic

> Fatigue Syndrome, 1997, 3, 3, 117-127.

>

> If so I would really appreciate a copy, if not a summary of

findings? Is

> fatigue a symptom of vit D deficiency.

>

> Regards, Blake