Guest guest Posted October 10, 1999 Report Share Posted October 10, 1999 FEAT DAILY ONLINE NEWSLETTER Families for Early Autism Treatment http://www.feat.org Article Archive: http://www.feat.org/listarchive/ Letters to the Editor, Submissions: FEAT@... " Healing Autism: No Finer a Cause on the Planet " ____________________________________________________________ DC Rally for Autism / New Movie Dyslexic / More Stem Research, Debate Saturday, October 09, 1999 Rally, Press Conference and Hearing on Tuesday, October 12 2:30pm The location for the rally/press conference is the House Triangle, east side of the capitol (opposite side from the Washington monument, on the left as you face the capitol). The podium, mikes, etc. will start to set up at 2:00, and they'll have a banner, so just look for the group. Try to arrive at 2:15pm. In case of rain (no hurricanes, thank you), they'll be in 2218 Rayburn HOB. Says CAN organizer Emkin, " it is critical we have a large turnout. PLEASE bring your kids, signs, and loud voices. This is our chance to be heard. " * * * New Movie Portrays Young Dyslexic Anya's Bell is a touching new television movie about a unique friendship between a blind woman and a dyslexic 12 year old boy who each take it upon themselves to teach and encourage the other to overcome their disabilities. Della Reese plays the title role. The movie airs on the CBS network on Sunday, October 31 (9:00 - 11:00 P.M., ET/PT). * * * Stem Cell Discovery Grows Into A Debate New Field Faces Tests On the Hill, in the Lab [by Rick Weiss Washington Post Staff Writer, Saturday, October 9, 1999.] It has been a year since researchers announced they had discovered in human embryos and fetuses a unique type of cell with the potential to treat a host of ailments, including diabetes, Parkinson's disease and even paralysis caused by spinal cord injury. Now, in the final weeks of bargaining over a new federal budget, a divided Congress is struggling to decide whether the medical promise of these " human embryonic stem cells " is great enough to justify the use of taxpayer money to study them, despite the fact that embryos and fetuses must be destroyed to get them. Congress has blocked federal funding of human embryo research for the past four years, but the discovery of stem cells has upped the ante in the embryo research debate. The research ban, which is attached to the appropriations bill for the departments of Labor and Health and Human Services, underwent several radical changes while the Senate addressed the bill last week, at various times containing prohibitions far stronger or weaker than in previous years. On Monday, the House will begin action on the issue. For many lawmakers, it is largely a question of whom they least wish to alienate: highly motivated and perhaps overly optimistic members of patient groups who believe that stem cells may soon save their lives or the lives of their loved ones, or equally passionate antiabortion activists who believe it is unethical to experiment on embryonic and fetal tissues. But for the many publicly funded scientists who want to investigate the cells, the issue is a no-brainer: The nation ought to enlist their help, they say, because it is becoming increasingly clear that it will not be easy to turn stem cells into cures. Among the more frustrating problems is how to get the cells to grow into the specific kinds of cells needed by patients, such as heart cells to be given to a heart attack victim or pancreas cells to be given to a diabetic. Today the cells behave as though they have a mind of their own, becoming whatever kind of cell they choose, and for no apparent reason. " You smile at them and they become heart, you frown and they become brain, " complained Tom Okarma, president and chief executive officer of Geron Corp. of Menlo Park, Calif., which has funded most of the human embryonic stem-cell work in this country. The challenges ahead, he said, " are formidable. " Indeed, while Okarma and others still hold high hopes that stem cells will lead to medical breakthroughs, ongoing studies by privately funded scientists at Geron and elsewhere have lent an air of sobriety to a field that a year ago seemed almost drunk with promise. For example, it is still difficult to keep stem cells alive in the laboratory, and it has been impossible to grow them in numbers large enough to be medically useful. Moreover, scientists still don't know how to engineer the cells so they won't be rejected by patients. " The only way we're going to figure all this out is to roll up our sleeves and do the nitty-gritty research, " said Harvard University cell biologist Evan Snyder. " There's such a clamor in the stem-cell field, but we should not let the clamor or the substantial promise seduce us into thinking we can do this quickly. " Embryonic stem cells are the basic, " plain vanilla " cells present at the core of newly developing animals. During prenatal development, they differentiate into more specialized cells, such as those that form the skin, liver, kidneys and brain. What makes them unique is their ability to multiply indefinitely in laboratory dishes, where they can give rise to offspring cells that also have the ability either to blandly reproduce or, under the right influence, specialize into any of the body's tissue types. Doctors hope they will be able to grow a smorgasbord of replacement tissues from stem cells, for transplantation into people who need them. After years of funding from Geron, two research teams announced simultaneously last fall that they had finally isolated human embryonic stem cells. One team retrieved them from young human embryos and the other from the immature sex organs of aborted fetuses. The best news so far is that the cells seem to be as immortal as advertised, said Thomson, the University of Wisconsin researcher who isolated human stem cells from leftover fertility clinic embryos. After almost two years of living and dividing in laboratory dishes, every new generation of cells seems just as young and full of potential as the previous one. To prove that, Thomson has injected into mice freshly grown human stem cells that are more than 300 generations removed from the parent cells he isolated from his original human embryo. Stem cells that have retained their full potential should, when they are injected into mice, differentiate into all the many kinds of tissues that they can become. And these 300th-generation cells have done so with exquisite creativity, Thomson said, with some of them becoming hair, others teeth, and still others little masses of cardiac cells that soon begin to beat in unison like a miniature heart. In fact, it is not difficult to get stem cells to differentiate into various tissues. The hard part is growing them into the specific kind of tissue you want -- and keeping them from specializing until you are ready. Scientists will have to grow huge vats of stem cells in their undifferentiated state if they are ever to commercialize them. Currently, however, the only way to keep the cells in this " primordial " state is to grow them in small dishes along with a special type of mouse cell. The mouse cells -- known as " feeder cells " -- somehow keep human stem cells from spontaneously following their urge to specialize. But despite valiant efforts, Thomson and others have failed to identify how the feeder cells do that. It is a bottleneck scientists will need to get through if the research is ever going to become useful for patients, because the mouse-cell system is too cumbersome to scale up to commercial levels. It's not an impossible task. Several years ago, researchers working with mouse embryonic stem cells were in the same bind: Those cells only retained their full potential when grown with finicky feeder cells. Then researchers found that a compound secreted by the feeder cells, called leukocyte inhibitory factor, or LIF, was the magic substance that was keeping the stem cells vital. Since then, scientists have just had to add some LIF to their dishes of stem cells, eliminating the need for feeder cells. " After that, the mouse studies took off, " recalled Pederson, a Geron-supported researcher of human stem cells at the University of California at San Francisco. Unfortunately, LIF does not do for human stem cells what it does for mouse stem cells, Pederson said. " Someone has to discover the LIF counterpart for human stem cells. " Perhaps even more daunting is the task of learning how to prod batches of stem cells to mature into specific kinds of cells for transplantation into people, such as liver cells for patients with cirrhosis or specific kinds of brain cells for patients with Alzheimer's or Parkinson's disease. Scientists have had some small successes in encouraging stem cells to turn into desired types, such as blood cells and nerve cells. Last December, for example, s Hopkins University researcher Gearhart stood before a Senate subcommittee and unveiled a poster-size photograph of spidery living cells with branched, outreaching arms. These appear to be healthy human brain cells, said Gearhart, grown in a laboratory dish from a starter batch of stem cells by feeding them a special recipe of nutrients. He plans to inject some into the brains of rodents this fall, to start assessing their potential as a treatment for brain diseases. But Gearhart's method is far from foolproof. Many stem cells treated with the same nutrients do not become neurons, and retain the potential to become bone, muscle or other cells later on -- cells that would not be welcome in a patient's brain. Even less is known about how to spur stem cells to grow with assuredness into other kinds of cells, such as the insulin-secreting pancreas cells that, given the prevalence of diabetes in this country, are foreseen by Geron as the first " blockbuster " moneymakers. Somehow, researchers will have to overcome stem cells' apparently fickle nature. Finally, there is the problem of immune-system rejection. Researchers want to figure out which molecules on stem cells are recognized as foreign by a patient's immune system. In theory, researchers could genetically engineer the cells to lack those molecules -- a simple-sounding strategy that scientists concede will probably take many years to implement. Depending on who is talking, problems such as these add up to an argument either for, or against, a quick infusion of federal funds. [For entire article, go to web link below, all on one line:] http://search.washingtonpost.com/wp-srv/WPlate/1999-10/09/085l-100999-idx.ht ml © Copyright 1999 The Washington Post Company ____________________________________________________________ editor: Lenny Schafer east coast editor: , Ph.D. schafer@... CIJOHN@... ***** WHY YOU MAY WANT TO SUBSCRIBE (or unsubscribe) ***** To The FEAT Daily Online Newsletter: Daily we collect features and news of the world of autism as it breaks. (no cost): http://www.feat.org/FEATNews Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.