Fibromyalgia and B6 phosphorylation.

[Guest guest]

Yes it is. Lessman's vitamins are made with it. Specifically, his B

complex.

[Guest guest]

This tells me that the best form of B6 in this case would be the

active form which is pyridoxal 5 phosphate.

Tammy

[Guest guest]

Are you referring to pyroluria? This is a condition that involves

difficulty processing B6 and Zinc, and also inability to break-down

adrenal products. I've been studying pyroluria, but hard to find info

on it. Pyroluria is possibly involved in a lot of cases of ADD/ADHD,

but also may play a role in adrenal disorders, where people tend easily

toward adrenal exhaustion.

--Kurt

Re: Fibromyalgia and B6 phosphorylation.

> This tells me that the best form of B6 in this case would be the

> active form which is pyridoxal 5 phosphate.

It's been claimed many people have a deficiency of the enzymes

necessary to break down B6, but there's a striking lack of studies

regarding this when I searched PUBMED. However, there are factors that

may increase the need for B6. For example, there's some evidence that

oral contraceptives can increase the need. Also, diabetes may

increase the risk for carpal tunnel, and other study claim that people

with diabetes need more B6. There are also some drugs that can

interfere with B6 metabolism:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & do

pt=Abstract & list_uids=9354586>

& db=pubmed & dopt=Abstract & list_uids=9354586

Some studies has shown that hypothyroidism might also be a factor,

which might be significant, given that many people have both

fibromyalgia and hypothryoidism. One study noted that carpal tunnel

was present for people who had low thyroid levels, even when they

weren't displaying any classical hypothyroid symptoms.

Since the normal thyroid range has been reduced in the last few years,

it's quite possible that many people in the past who had carpal

tunnel, but were told they didn't have hypothyroidism, might actually

have had hypothyroidism.

Mark

This list is intended for patients to share personal experiences with

each other, not to give medical advice. If you are interested in any

treatment discussed here, please consult your doctor.

[Guest guest]

There is some information on this condition in a book by Ross

called The Mood Cure.

Helen

> > This tells me that the best form of B6 in this case would be the

> > active form which is pyridoxal 5 phosphate.

>

> It's been claimed many people have a deficiency of the enzymes

> necessary to break down B6, but there's a striking lack of studies

> regarding this when I searched PUBMED. However, there are factors

that

> may increase the need for B6. For example, there's some evidence

that

> oral contraceptives can increase the need. Also, diabetes may

> increase the risk for carpal tunnel, and other study claim that

people

> with diabetes need more B6. There are also some drugs that can

> interfere with B6 metabolism:

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve

> <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & do

> pt=Abstract & list_uids=9354586>

> & db=pubmed & dopt=Abstract & list_uids=9354586

>

> Some studies has shown that hypothyroidism might also be a factor,

> which might be significant, given that many people have both

> fibromyalgia and hypothryoidism. One study noted that carpal tunnel

> was present for people who had low thyroid levels, even when they

> weren't displaying any classical hypothyroid symptoms.

>

> Since the normal thyroid range has been reduced in the last few

years,

> it's quite possible that many people in the past who had carpal

> tunnel, but were told they didn't have hypothyroidism, might

actually

> have had hypothyroidism.

>

> Mark

>

>

>

>

>

>

>

> This list is intended for patients to share personal experiences

with

> each other, not to give medical advice. If you are interested in

any

> treatment discussed here, please consult your doctor.

>

>

>

>

>

>

[Guest guest]

*Fibromylagia*

Finally there is a clear association of carpal tunnel syndrome in

patients with fibromylagia as shown in a study by -Ruiz and

associates.

Attributed to Carl Pfeiffer M.D., Ph.D. is the observation that the

" Morton's Foot " , a foot form with the 2nd toe as long or longer as the

1st toe, seen in approximately one-fourth to one-fifth of the

population, is associated with an inability to phosphorlyate pyridoxine

to its active form pyridoxal phosphate. The author in cooperation with

Ellis M.D. of the Institute of Biomedical Research of the

University of Texas at Austin has identified 97 out of 98 patients with

fibromylagia and the Morton foot. with diminished pyridoxal phosphate

stores by measuring EGOT, suggesting phosphorylation has been diminished

in these patients ranging from 10 to 50% of normal. Indeed, Devin

Starlanyl M.D. and Copeland M.S. has also observed this association

of the Morton Foot and fibromylagia and coined the term "

FMS/MPS " (fibromylagia/ myofascial pain syndrome) foot and callus pattern.

From http://www.gutdoc.org/VitaminB6.htm

[Guest guest]

Thanks, the links on that page were helpful.

--Kurt

Re: Re: Fibromyalgia and B6

phosphorylation.

Kurt,

See my page on pyroluria:

<http://www.nutritional-healing.com.au/content/articles-content.php?head

ing=Pyroluria>

It has a list of article links and links to labs which test for this.

Regards, Blake

helen9jora wrote:

>There is some information on this condition in a book by Ross

>called The Mood Cure.

>

>Helen

>

>

>

>

>

>>Are you referring to pyroluria? This is a condition that involves

>>difficulty processing B6 and Zinc, and also inability to break-down

>>adrenal products. I've been studying pyroluria, but hard to find

>>

>>

>info

>

>

>>on it. Pyroluria is possibly involved in a lot of cases of

>>

>>

>ADD/ADHD,

>

>

>>but also may play a role in adrenal disorders, where people tend

>>

>>

>easily

>

>

>>toward adrenal exhaustion.

>>--Kurt

>>

[Guest guest]

Kurt,

See my page on pyroluria:

<http://www.nutritional-healing.com.au/content/articles-content.php?heading=Pyro\

luria>

It has a list of article links and links to labs which test for this.

Regards, Blake

helen9jora wrote:

>There is some information on this condition in a book by Ross

>called The Mood Cure.

>

>Helen

>

>

>

>

>

>>Are you referring to pyroluria? This is a condition that involves

>>difficulty processing B6 and Zinc, and also inability to break-down

>>adrenal products. I've been studying pyroluria, but hard to find

>>

>>

>info

>

>

>>on it. Pyroluria is possibly involved in a lot of cases of

>>

>>

>ADD/ADHD,

>

>

>>but also may play a role in adrenal disorders, where people tend

>>

>>

>easily

>

>

>>toward adrenal exhaustion.

>>--Kurt

>>