Immunomodulators--samento & cytokines

[Guest guest]

> nina smiles

Hi Group,

Cytokines

Pro-inflammatory cytokines are a number of polypeptides and

glycoproteins with molecular weights between 5 KDa and 70 KDa. They

have a stimulating effect on the inflammatory response. The most

important pro-inflammatory cytokines are TNF (tumor necrosis factor),

IL-1 (interleukin-1), IL-6 and IL-8. The cytokines are produced by

various cell types, but the major synthesis takes place in activated

lymphocytes, monocytes and macrophages. IL-6 is a potent stimulator

of liver synthesis of the acute phase proteins and IL-8 a strong

activator of the neutrophile granulocytes chemotaxi and upregulation

of their adhesion molecules, cellular endothelial adhesion and cell

migration across the vascular wall.

The anti-inflammatory cytokines IL-4, IL-10, IL-13, IL-1ra (IL-1-

receptor antagonist) and TNFsr (TNF-soluble receptors) are also

produced by lymphocytes, monocytes and macrophages including the

Kuppfer cells of the liver. They act by lowering or blocking the

inflammatory response, either by inhibiting the production of the pro-

inflammatory cytokines, indirectly by neutralizing circulating pro-

inflammatory cytokines or by stimulating the production of receptor

blocking cytokines IL-1ra and TNFsr. In uncomplicated situations

with simple minor surgical interventions, the entire cascade of

cytokine responses lasts for a few hours only, whereas in more

complicated situations some (a few or many) of the components may

continue to (over)react much longer.

Cytokines in CFS

http://www.ahmf.org/database/cytokines.html

" Several groups have noted alterations in cytokine levels in patients

with CFS. Increased IL-1,2,6,neopterin, IFNa, TNFa,B and TGF-B.

However...there are just as many studies which report normal levels

of these cytokines...Spontaneous production of several

proinflammatory cytokines including IL-1a, IL-1B, IL-6 and TNFa and B

by cultured lymphocytes has consistently been shown to be normal in

patients with CFS compared to healthy controls. Interestingly, some

of these cytokines are known to induce sx similar to those reported

in patients with CFS...a recent study showed a *significant increase

in serum TNFa in patients with CFS. Whether these abnormalities have

any relationship to the symptoms reported by patients with CFS

remains unclear. In the only study to examine this question,

clinical improvement in CFS was not assosciated with changes in

lymphocyte subsets or activation. "

CFS, a biological approach. DeMeirleir, Englebienne.

Summary of Immunomodulatory effects of Samento:

inhibits NF-KB, mild COX-1, COX-2, *potent TNF-a inhibitor

increases IL-1,2,6,8 (pro-inflammatory cytokines)

peroxynitrite scavenger

http://www.samento.com.ec/sciencelib/sammain.html ****many good

articles

Looks good for Lyme,possible CFS, also good article about

misdiagnosed Lyme as CFS (something like 90+% in the study!!)

(probably shouln't mix this with any other antiinflammatories,

3 month trial may be in order--keep us posted!)

Found this interesting out of the Database:

Bojungikki-tang (BIT)

Kuibitang (KBT) is clinically used to treat patients suffering from

chronic fatigue syndrome (CFS) in South Korea. However, its effect

has not been investigated experimentally. Recent reports have shown

that CFS patients display an altered cytokine production. We examined

the effect of KBT on lipopolysaccharide (LPS)-induced various

cytokines production in peripheral blood mononuclear cells (PBMC) of

CFS patients and healthy controls. KBT (1 mg/ml) significantly

inhibited LPS-induced tumor necrosis factor-alpha, interleukin-10,

and transforming growth factor-beta1 production in PBMC of CFS

patients. However, LPS-induced interferon-gamma production was

significantly increased by KBT (0.01 mg/ml). These results provide

evidence of a novel activity of the KBT that regulate cytokines

production related with CFS.

Cheney points out IL-10 vs IL-12 importance in shifting to TH1.

Above looks like good immunomodulator for TNFa, IL-10, IL-6.

Imagine this would be available from any chinese medicine

practitioner here.

Error in database: long acting NAC (sustain) has limited

bioavailability. My bad.

tea lk, thanks for info re: gastric upset