Re: Immunovir (Insosine) OTC alternatives/Mike

[Guest guest]

Hyde did publish 1-2 promising studies on Imunovir. Small number of

subjects, but the drug was shown to be effective. Check the Jrnl of CFS, maybe

even

PubMed.

In a message dated 3/1/2005 5:41:58 PM Eastern Standard Time,

davidhall@... writes:

> I don't know about the OTC possible alternative to Immunovir, but what I

> can say is that IMO the above statement is questionable(can you cite a

research

> paper showing this?)

[Guest guest]

(Immunovir is the antiviral which Dr Hyde has used with

> promising results).

Hi, Mike.

I don't know about the OTC possible alternative to Immunovir, but what I can say

is that IMO the above statement is questionable(can you cite a research paper

showing this?) and that Dr Cheney has used Immunovir for years in his patients

but only with modest immunomodulative impact for TH2 side immune system

demonstrated dominance in patients.(Check out

http://www.virtualhometown.com/dfwcfids)

Immunovir is a good TNFa inflammation suppresor I have found when I tried it

while going through Dr Cheney's bovine growth factors(bGFs) and low dose human

growth hormone(hGH) therapy. It clearly prevents painful joint and connective

tissue pain you can get from the increased TNFa levels while doing this type of

thing, but by no means did I find it to be helpful my core ME/CFS symptoms.

[Guest guest]

Here's something the drug company sent me (and lots of others, judging by

the " " line.

They presumably were happy for it to be circulated given the wording.

Tom K.

--------------------------------

As you may be aware, Newport Pharmaceuticals Ltd has been actively involved

in the clinical development of inosine pranobex* (Isoprinosine) for chronic

fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) since 1997.

In 1998, we conducted a pilot study in Canada, the results of which

suggested that taking inosine pranobex may benefit a subgroup of patients

with CFS and that this improvement is associated with enhanced NK cell

function and increased levels of IL-12 cytokine. The study results are

summarized in the following publication:

-Mitoma F, Turgonyi E, Kumar A, et al. Clinical improvement in chronic

fatigue syndrome is associated with enhanced natural killer cell-mediated

cytotoxicity: the results of a pilot study with Isoprinosine*. Journal of

Chronic Fatigue Syndrome Volume 11, November 2; 2003

The official JCFS Abstract can be found at

https://www.haworthpress.com/store/ArticleAbstract.asp?sid=1N0TUDE04J6W8N10Q

D6NCJPGCV0W0GU0 & ID=33600

<https://www.haworthpress.com/store/ArticleAbstract.asp?sid=1N0TUDE04J6W8N10

QD6NCJPGCV0W0GU0 & ID=33600>

The full PDF version is downloadable at

www.rivexpharma.com/products_imunovir.html

<http://www.rivexpharma.com/products_imunovir.html>

In the United Kingdom, Prof. Pinching in St Bartholomew's Hospital,

London has carried out an open-label study in which 200 CFS patients were

treated with inosine pranobex (Imunovir) over a period of 5 years.

Improvement was noted in 52% of the patients who underwent treatment with

Imunovir. Professor Pinching presented his findings as a poster at Fatigue

2002 in London - the poster abstract is attached. Professor Pinching was

also the Deputy chair of the UK Working Group on CFS/ME.

We are pleased to bring this new information to CFS/ME Support Groups

worldwide. We understand that CFS/ME is not a licensed indication for

Isoprinosine/Imunovir in any country and that presently there is no approved

drug treatment for CFS in any part of the world. However, we hope that the

above information is of benefit to your members as the awareness of CFS

gradually increases worldwide.

If you require any further information, please do not hesitate to contact

me.

Regards

Esther Smyth

CLINICAL AFFAIRS ADMINISTRATOR

Newport Pharmaceuticals Ltd

Frans Maas House

Swords Business Park

Swords

Co Dublin

Ireland

Tel: + 353 1 890 3011 (GMT)

Fax: + 353 1 890 3016

<<Pinching Fatigue 2002.doc>>

--------------

FATIGUE 2002

A National Conference - May 17th & 18th 2002

1 Great Street, Westminster, London SW1P 3AA

Organised by: The National ME Centre

Abstract from Poster Presentation

TITLE: INOSINE PRANOBEX IN THE TREATMENT OF CHRONIC FATIGUE SYNDROME - a

pilot study

NAME OF AUTHOR / SPEAKER: ANTHONY J PINCHING

St Bartholomew's Hospital, West field, D Phil, FRCP Professor of

Immunology, Barts & The London, Queen 's University of London, London,

EC1A 7BE

Tel: 020-7601-8428 Fax: 020-7600-3839

ABSTRACT SUMMARY

Purpose: Chronic fatigue syndrome (CFS) is commonly triggered by infection

and there is evidence of immune dysregulation. Inosine pranobex (Imunovir)

is an oral biological response modifier, which has potential utility in CFS.

This study assessed by observational analysis the clinical effectiveness and

tolerability of inosine pranobex in CFS patients treated with this agent.

Procedures: Audit of open label clinical usage of inosine pranobex (1 gr.

Tds for 1 month) in 200 people with CFS who were stable or deteriorating on

existing treatment. The outcome measures used were changes in symptoms and

activity levels, and side effects.

Findings: Some degree of clinical improvement (reduced symptoms, increased

sustainable activity or both) occurred in 30% (definite) or 52% (definite

plus probable), typical (in 90%) some months after the courses, lasting some

months;

84% of retreated responders responded again. The commonest side effects

were an increase in CFS symptoms during the course affecting some 41%. In

those with such side effects, lower dose courses (0.5 gr. Tds for 2 months)

were better tolerated but comparably effective.

Conclusions: These very preliminary results suggest that a clinical trial of

inosine pranobex in CFS is justified, using the lower dosing, and imply that

immune mechanisms are involved.

Ref: CFS/ME Working Group (2002) A report of the CFS/ME Working Group.

Report to the Chief Medical Officer of an Independent Working Group London:

Department of Health

Re: Re: Immunovir (Insosine) OTC

alternatives/Mike

Hyde did publish 1-2 promising studies on Imunovir. Small number of

subjects, but the drug was shown to be effective. Check the Jrnl of CFS,

maybe even

PubMed.

In a message dated 3/1/2005 5:41:58 PM Eastern Standard Time,

davidhall@... writes:

> I don't know about the OTC possible alternative to Immunovir, but what I

> can say is that IMO the above statement is questionable(can you cite a

research

> paper showing this?)

[Guest guest]

I noticed before and have just noticed again that people spell it Immunovir

(presumably on the lines of " immune " ) while the drug company spell it

Imunovir. This might possibly be relevant not necessarily in this case but

in some cases when doing searches.

Tom K.

RE: Re: Immunovir (Insosine) OTC

alternatives/Mike

Here's something the drug company sent me (and lots of others, judging by

the " " line.

They presumably were happy for it to be circulated given the wording.

Tom K.

--------------------------------

As you may be aware, Newport Pharmaceuticals Ltd has been actively involved

in the clinical development of inosine pranobex* (Isoprinosine) for chronic

fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) since 1997.

In 1998, we conducted a pilot study in Canada, the results of which

suggested that taking inosine pranobex may benefit a subgroup of patients

with CFS and that this improvement is associated with enhanced NK cell

function and increased levels of IL-12 cytokine. The study results are

summarized in the following publication:

-Mitoma F, Turgonyi E, Kumar A, et al. Clinical improvement in chronic

fatigue syndrome is associated with enhanced natural killer cell-mediated

cytotoxicity: the results of a pilot study with Isoprinosine*. Journal of

Chronic Fatigue Syndrome Volume 11, November 2; 2003

The official JCFS Abstract can be found at

https://www.haworthpress.com/store/ArticleAbstract.asp?sid=1N0TUDE04J6W8N10Q

D6NCJPGCV0W0GU0 & ID=33600

<https://www.haworthpress.com/store/ArticleAbstract.asp?sid=1N0TUDE04J6W8N10

QD6NCJPGCV0W0GU0 & ID=33600>

The full PDF version is downloadable at

www.rivexpharma.com/products_imunovir.html

<http://www.rivexpharma.com/products_imunovir.html>

In the United Kingdom, Prof. Pinching in St Bartholomew's Hospital,

London has carried out an open-label study in which 200 CFS patients were

treated with inosine pranobex (Imunovir) over a period of 5 years.

Improvement was noted in 52% of the patients who underwent treatment with

Imunovir. Professor Pinching presented his findings as a poster at Fatigue

2002 in London - the poster abstract is attached. Professor Pinching was

also the Deputy chair of the UK Working Group on CFS/ME.

We are pleased to bring this new information to CFS/ME Support Groups

worldwide. We understand that CFS/ME is not a licensed indication for

Isoprinosine/Imunovir in any country and that presently there is no approved

drug treatment for CFS in any part of the world. However, we hope that the

above information is of benefit to your members as the awareness of CFS

gradually increases worldwide.

If you require any further information, please do not hesitate to contact

me.

Regards

Esther Smyth

CLINICAL AFFAIRS ADMINISTRATOR

Newport Pharmaceuticals Ltd

Frans Maas House

Swords Business Park

Swords

Co Dublin

Ireland

Tel: + 353 1 890 3011 (GMT)

Fax: + 353 1 890 3016

<<Pinching Fatigue 2002.doc>>

<snip>

[Guest guest]

Hi Tom and all,

> I noticed before and have just noticed again that people spell it

Immunovir

> (presumably on the lines of " immune " ) while the drug company spell

it

> Imunovir. This might possibly be relevant not necessarily in this

case but

> in some cases when doing searches.

You might be correct. I thought Newport Pharma. called it

Isoprinosine, and Immonovir was a geographical variant. But it

seems an awful lot of people are confused:

http://www.google.com/search?sourceid=navclient & ie=UTF-

8 & rls=GGLC,GGLC:1970-01,GGLC:en & q=immunovir

Including the NIH, BMJ, and so on... They could just be typos, it's

almost begging to be mispelled if you stick a prefix " immuno " on

front of somehting but then insist it should only have one 'm'.

TC

Mike

>

> Tom K.

> RE: Re: Immunovir (Insosine) OTC

> alternatives/Mike

>

>

> Here's something the drug company sent me (and lots of others,

judging by

> the " " line.

<snip>

[Guest guest]

Hi Mike,

> Re: Immunovir (Insosine) OTC

>alternatives/Mike

>

>

>

>Hi Tom and all,

>

>

>> I noticed before and have just noticed again that people spell it

>Immunovir

>> (presumably on the lines of " immune " ) while the drug company spell

>it

>> Imunovir. This might possibly be relevant not necessarily in this

>case but

>> in some cases when doing searches.

>

>You might be correct. I thought Newport Pharma. called it

>Isoprinosine, and Immonovir was a geographical variant. But

>it seems an awful lot of people are confused:

>

>http://www.google.com/search?sourceid=navclient & ie=UTF-

>8 & rls=GGLC,GGLC:1970-01,GGLC:en & q=immunovir

>

>Including the NIH, BMJ, and so on... They could just be

>typos, it's almost begging to be mispelled if you stick a

>prefix " immuno " on front of somehting but then insist it

>should only have one 'm'.

>

>TC

>Mike

I checked in a book for prescribing doctors.

It lists drugs by their brand name.

It has both:

Imunovir - Inosine Pranobex (Newport Synthesis)

And

Isoprinosine - Inosine Pranobex (Newport Synthesis)

(separately for some reason)

As you say, it's almost begging to be misspelt and if you google immunovir

and see 200 results, you might think they were all the results

(and similarly if google " imunovir " and see 5000 results).

Bye,

Tom

[Guest guest]

Oops. The (T) and ® registered trademark-type symbols didn't come out

with brackets around them.

Here that is again:

http://answers.google.com/answers/threadview?id=461263

" ..Imunovir is also known in different parts of the world as

Isoprinosine, Viruxan, Prinosine and Virimun.. "

Happy searching (anybody who is interested)!

Tom

(as if I wasn't in enough people's bad books for circulating all those

messages about the matching research appeals! :-(

RE: Re: Immunovir (Insosine) OTC

alternatives/Mike

http://answers.google.com/answers/threadview?id=461263

" ..ImunovirT is also known in different parts of the world as

IsoprinosineR, ViruxanR, PrinosineR and VirimunR.. "

Happy searching (anybody who is interested)!

Tom

[Guest guest]

Hi Mike,

Try this old message for some info. on creating

Imunivor.

/message/40266

<snip>

You may be interested to note that a very close,

effective approximation to Isoprinosine/Imunovir can

be made by using products that can be purchased

without the need for a prescription. These are Inosine

and PABA, both of which can be obtained from health

foods stops, or in the case of Inosine, those that

sell supplements for sporting activities.

I used this approach before my Doctor

prescribed Isoprinosine/Imunovir, and it did work. In

similarity to Isoprinosine/Imunovir, the dose was

3000mg of Inosine daily in three divided

doses with 50mg or 100mg of PABA with each dose.

<snip>

Thanks to Porter for this recipe.

Good luck!

With warmest regards,

Send instant messages to your online friends http://uk.messenger.

[Guest guest]

Hi Annette,

Many thanks for that... I vaguely rmember reading that now. I guess it

would turn out to be predictively expensive if I need to add another supp

to get the effect...

I suppose without the PABA the inosine may turn out to be " just " an ATP

booster and cardioprotective, and neuroptrotective, which isn't too shoddy

in my books though

:-) Early days yet but IME it does seem to help a bit.

http://www.strokedoctor.com/new_break.htm

http://www.pdg.cnb.uam.es/UniPub/iHOP/pm/1513834.html

http://www.google.com/search?sourceid=navclient & ie=UTF-8 & rls=GGLC,GGLC:1970-01,G\

GLC:en & q=site:www%2Encbi%2Enlm%2Enih%2Egov+ATP+inosine+cardioprotective

TC

Mike

At 22:38 02/03/2005 +0000, you wrote:

>Hi Mike,

>

>Try this old message for some info. on creating

>Imunivor.

>

></message/40266>http://he\

alth./group//message/40266

>

><snip>

>You may be interested to note that a very close,

>effective approximation to Isoprinosine/Imunovir can

>be made by using products that can be purchased

>without the need for a prescription. These are Inosine

>and PABA, both of which can be obtained from health

>foods stops, or in the case of Inosine, those that

>sell supplements for sporting activities.

>

>I used this approach before my Doctor

>prescribed Isoprinosine/Imunovir, and it did work. In

>similarity to Isoprinosine/Imunovir, the dose was

>3000mg of Inosine daily in three divided

>doses with 50mg or 100mg of PABA with each dose.

><snip>

>

>Thanks to Porter for this recipe.

>

>Good luck!

>

>With warmest regards,

>

>

>Send instant messages to your online friends

><http://uk.messenger.>http://uk.messenger.

>

>

>This list is intended for patients to share personal experiences with each

>other, not to give medical advice. If you are interested in any treatment

>discussed here, please consult your doctor.

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