STUDY on STRESS and NK activity...

[Guest guest]

Thought this was interesting. Proof that stress affects the

immune system, especially that percieved as uncontrollable (my

life for the last 5-7- years...)

Brain Behav Immun. 1992 Jun;6(2):141-56. Related Articles,

Links

Modulation of human natural killer cell activity by exposure to

uncontrollable stress.

Sieber WJ, Rodin J, Larson L, Ortega S, Cummings N, Levy S,

Whiteside T, Herberman R.

Department of Psychology, Yale University, New Haven,

Connecticut 06520-7447.

Changes in natural killer cell (NK) activity and proportions of

circulating T and NK lymphocyte subsets were assessed in

adult males immediately after exposure to controllable or

uncontrollable stress (noise) as well as 24 and 72 h later, in

order to track the time course of the effects of stress. The role of

control-relevant personality variables as moderators of the

stress-immunosuppression relationship was considered.

Subjects who perceived they had control over the noise as well

as no-noise " control " subjects showed no reduction in NK

activity.

By contrast, subjects who perceived that they had no control over

the stressor showed reduced NK activity immediately after the

conclusion of the first 20-min stress session, and the reduced

NK activity was found as long as 72 h later.

Optimism and one's desire to be in control enhanced the

negative impact of uncontrollable noise on NK activity. No

differences between conditions were found on number of NK

cells or a variety of T cell subsets. The results suggest the

importance of perceived control in moderating the short- and

long-term effects of stress on NK activity.

[Guest guest]

Thanks for this very timely, interesting post!!!

bg

>

> Thought this was interesting. Proof that stress affects the

> immune system, especially that percieved as uncontrollable (my

> life for the last 5-7- years...)

>

> Brain Behav Immun. 1992 Jun;6(2):141-56. Related Articles,

> Links

>

> Modulation of human natural killer cell activity by exposure to

> uncontrollable stress.

>

> Sieber WJ, Rodin J, Larson L, Ortega S, Cummings N, Levy S,

> Whiteside T, Herberman R.

> Department of Psychology, Yale University, New Haven,

> Connecticut 06520-7447.

>

> Changes in natural killer cell (NK) activity and proportions of

> circulating T and NK lymphocyte subsets were assessed in

> adult males immediately after exposure to controllable or

> uncontrollable stress (noise) as well as 24 and 72 h later, in

> order to track the time course of the effects of stress. The role

of

> control-relevant personality variables as moderators of the

> stress-immunosuppression relationship was considered.

>

> Subjects who perceived they had control over the noise as well

> as no-noise " control " subjects showed no reduction in NK

> activity.

>

> By contrast, subjects who perceived that they had no control over

> the stressor showed reduced NK activity immediately after the

> conclusion of the first 20-min stress session, and the reduced

> NK activity was found as long as 72 h later.

>

> Optimism and one's desire to be in control enhanced the

> negative impact of uncontrollable noise on NK activity. No

> differences between conditions were found on number of NK

> cells or a variety of T cell subsets. The results suggest the

> importance of perceived control in moderating the short- and

> long-term effects of stress on NK activity.

[Guest guest]

If you want to convince the psychiatric causality theorists that CFS

is stress induced, emphasing the effects of stress is a good way to

make sure that the therapy and research into CFS will be behavioral

modification.

The fact remains that humans have lived under situations of intense

stress without having any level of stress correlate to initiation of

CFSlike syndromes.

The association of stress with exacerbation of symptoms only

demonstrates a peculiar susceptibilty to stress in CFS.

It in no way suggests causality, any more than Candida infections in

AIDS suggests that formerly benign fungal organisms are primary in

the immunological cascade that kills AIDS victims.

If you don't want psycho-terrorists to maintain their ability to deny

the reality of your illness, I would look very carefully at the

historical inability of stress to cause CFS.

-

[Guest guest]

Hi Kdrbrill,

Are you sure that you would want to accept this as

proof?

This is just an abstract of a study on some adult

males. It contains some " religious thinking " such as

the use of the words optimism (or do they have a blood

test for that?).

Is there any proof that women or people with CFS & ME

react in the same way and was the study ever

reproduced elsewhere?

If I wanted to accept something as " proof " I would

tend to read the entire article and dig a little to

find out about the researchers.

Having seen remarks about stress and M.E. and CFS made

by a " researchers " that had his research discredited

years afterwards (Dr. Nixon, Charing Cross

Hospital, London), I am sceptical about some research

esp. when a " spin " is put on it.

With warmest regards,

Annette

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[Guest guest]

I'm just saying it's part of the puzzle. Just part -- not THE cause. I

don't know about the doctor's you mentioned, but perhaps they

were suggesting that it was the cause of cfids/me/fibro.

And I only posted it because it seems like some people just

expect a pill or pills to be the answer, when we have to take

some responsibility for our choices, and although easier said

than done, we all know of the many stories of pushing ourselves

too hard, and then crashing. I still do it at times, even though I

know the consequences. That " pushing " is stress, and our

weakened adrenals, or weakened bodies react to stress

differently than healthy controls. I think that's pretty well

established, so at least for me, it's something I want to work on.

(Also have seen clinical studies showing that candida infections

multiply much faster under periods of stress.)

d.

> Hi Kdrbrill,

>

> Are you sure that you would want to accept this as

> proof?

>

> This is just an abstract of a study on some adult

> males. It contains some " religious thinking " such as

> the use of the words optimism (or do they have a blood

> test for that?).

>

> Is there any proof that women or people with CFS & ME

> react in the same way and was the study ever

> reproduced elsewhere?

>

> If I wanted to accept something as " proof " I would

> tend to read the entire article and dig a little to

> find out about the researchers.

>

> Having seen remarks about stress and M.E. and CFS made

> by a " researchers " that had his research discredited

> years afterwards (Dr. Nixon, Charing Cross

> Hospital, London), I am sceptical about some research

> esp. when a " spin " is put on it.

>

> With warmest regards,

> Annette

>

>

>

>

>

>

>

>

>

>

>

>

>

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