Guest guest Posted November 15, 2004 Report Share Posted November 15, 2004 I was not aware that Dr. Cheney was practising anymore since his heart transplant over a year ago. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 16, 2004 Report Share Posted November 16, 2004 I understand he's slowly but surely restarting his practice. I think he's started selling tapes/cds of past lectures, and also possibly supplements? > > I was not aware that Dr. Cheney was practising anymore since his heart > transplant over a year ago. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 Tim, I think this is a very interesting development. I have begun to suspect that cardiomyopathy can be caused by glutathione depletion in the heart muscle. The mechanism would be the same as the one Marty Pall and I have been suggesting for the skeletal muscle in CFS: a rise in peroxynitrite. Yesterday there was a news item concerning stress-induced cardiomyopathy (abstract pasted below). This occurs in some people after a sudden emotional stress, and it acts like a heart attack, but there is no evidence of decreased blood flow to heart muscle or residual damage. I suspect that in this condition the elevated catecholamines temporarily lower the glutathione level in the heart muscle, and that allows peroxynitrite to rise and to inhibit the oxidative metabolism of the heart muscle, thus lowering the rate of ATP production, and robbing the heart muscle of the fuel it needs to contract. In other words, what I'm suggesting is that stress-induced cardiomyopathy ia an acute version of what happens in some PWCs chronically, and that it is due to an acute glutathione depletion in the heart, as compared to chronic glutathione depletion in CFS. Rich > , > > Dr. Cheney is now closely following Dr. Peckerman's work with impedance > cardiography. He bought his own machine with a grant from the Dallas-Ft. > Worth folks. He hypothesizes that CFS and idiopathic cardiomyopathy are > practically synonymous! His ideas have definitely changed, but it doesn't > sound like you need to see him. > > Tim Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 Tim, Sorry, I forgot to paste in the abstract in my previous message. Here it is. Rich N Engl J Med. 2005 Feb 10;352(6):539-48. Neurohumoral features of myocardial stunning due to sudden emotional stress. Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC. Division of Cardiology, Department of Medicine, s Hopkins University School of Medicine, Baltimore, USA. iwittste@... BACKGROUND: Reversible left ventricular dysfunction precipitated by emotional stress has been reported, but the mechanism remains unknown. METHODS: We evaluated 19 patients who presented with left ventricular dysfunction after sudden emotional stress. All patients underwent coronary angiography and serial echocardiography; five underwent endomyocardial biopsy. Plasma catecholamine levels in 13 patients with stress-related myocardial dysfunction were compared with those in 7 patients with Killip class III myocardial infarction. RESULTS: The median age of patients with stress-induced cardiomyopathy was 63 years, and 95 percent were women. Clinical presentations included chest pain, pulmonary edema, and cardiogenic shock. Diffuse T-wave inversion and a prolonged QT interval occurred in most patients. Seventeen patients had mildly elevated serum troponin I levels, but only 1 of 19 had angiographic evidence of clinically significant coronary disease. Severe left ventricular dysfunction was present on admission (median ejection fraction, 0.20; interquartile range, 0.15 to 0.30) and rapidly resolved in all patients (ejection fraction at two to four weeks, 0.60; interquartile range, 0.55 to 0.65; P<0.001). Endomyocardial biopsy showed mononuclear infiltrates and contraction-band necrosis. Plasma catecholamine levels at presentation were markedly higher among patients with stress-induced cardiomyopathy than among those with Killip class III myocardial infarction (median epinephrine level, 1264 pg per milliliter [interquartile range, 916 to 1374] vs. 376 pg per milliliter [interquartile range, 275 to 476]; norepinephrine level, 2284 pg per milliliter [interquartile range, 1709 to 2910] vs. 1100 pg per milliliter [interquartile range, 914 to 1320]; and dopamine level, 111 pg per milliliter [interquartile range, 106 to 146] vs. 61 pg per milliliter [interquartile range, 46 to 77]; P<0.005 for all comparisons). CONCLUSIONS: Emotional stress can precipitate severe, reversible left ventricular dysfunction in patients without coronary disease. Exaggerated sympathetic stimulation is probably central to the cause of this syndrome. Copyright 2005 Massachusetts Medical Society. PMID: 15703419 [PubMed - in process] > > , > > > > Dr. Cheney is now closely following Dr. Peckerman's work with > impedance > > cardiography. He bought his own machine with a grant from the > Dallas-Ft. > > Worth folks. He hypothesizes that CFS and idiopathic > cardiomyopathy are > > practically synonymous! His ideas have definitely changed, but it > doesn't > > sound like you need to see him. > > > > Tim Quote Link to comment Share on other sites More sharing options...
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