Calcium AEP, phosphate diabetes etc

[Guest guest]

In response to the various points that have been raised, first, here are

my latest notes on AEP. If you read them carefully, they should answer

many of the questions that get asked from time to time. I have many

demands on my time and if some say they do not have time to keep up with

the list, I'm sure they will understand if I say that I do not have time

to write to members individually.

2-AEP

This form of calcium, magnesium and other minerals is a complex subject

not made easier by the lack of agreement on terminology. It is believed to

carry minerals to the outer layer of the outer cell membrane and is known

in German literature as membrane integrity factor or vitamin Mi, and in

English literature as colamine phosphate salts or phosphonates. To take

the case of calcium, it is known as calcium 2-aminoethyl phosphate

or -aminoethylphosphonic acid (Ca 2-AEP) or calcium ethanolamine phosphate

ester (Ca EAP-2) and there are other versions of these names. Here, I use

2-AEP, which is the most common abbreviation, though the UK products that

I use are called EAP2. Calcium 2-AEP is 13.5% elemental calcium; magnesium

2-AEP is 14.5% elemental magnesium.

Ca 2-AEP is an essential factor for cell membrane integrity. It binds

fatty acids and electrolytes to the cell membrane structure that generates

the cell's electrical charge. Studies have shown that Ca 2-AEP is

essential for neurotransmission, nerve impulse generation, and muscular

contractions. Among its functions are the following.

a.. Cells allow entry of vital nutrients through pores spread across the

cellular membrane. Two types of pores predominate: free lipid pores and

peptide-lined transport pores. Lipid pores can permit the unwanted

penetration into cells by harmful agents. Ca 2-AEP helps to seal the lipid

cellular membrane pores of the outer cell membrane, against unwanted

substances - toxins, bacteria, viruses, antibodies and other harmful

agents.

b.. It facilitates the cellular exchange of inorganic electrolytes and

aids the absorption of nutrient substances such as fatty acids, amino

acids, carbohydrates, vitamins, hormones and steroids through the 'active

transport pores' of cell membranes. Taking Ca 2-AEP will therefore assist

the transport of magnesium into the cells, although the two minerals are

usually thought of as competing for uptake.

c.. It helps the cells to retain the electrical charges of calcium,

potassium and magnesium ions residing on the membrane surface where they

serve to increase the conductivity of nerve tissue. It does this by

causing calcium and other minerals to bind to cellular membranes where

they serve as electrical condensers, essential for cellular regulation.

This condenser function of the cell membrane plays an active role in

disease prevention. If there is an insufficient amount of colamine

phosphate salts, the cell's electrical charge and condenser function will

be abnormal. A significant loss of the electrical charge of the cell

membrane may have grave consequences for the circulatory, immune and

neuromuscular systems.

Living cells have a membrane potential of about -70mV. In healthy tissue

the inside of the cell is negative relative to its external surface, but

when tissues are injured, sodium and water flow in to the cells and

potassium, magnesium and zinc are lost from the cell interior. The change

in mineral content of the cell is one of the major factors causing injured

cells to have lower membrane potential. A healthy cell membrane potential

is strongly linked to the control of cell membrane transport mechanisms as

well as DNA activity and protein synthesis, so injured cells, which cannot

maintain normal membrane potential, will have electronic dysfunction that

will impede repair and rejuvenation processes. Some of the most important

factors implicated in musculoskeletal repair and regeneration involve

natural electrical properties of the body's tissues and cells, such as

cell membrane potential (capacitance) and protein semiconduction of

electricity. The body utilises these fundamental bioelectric features to

produce electrical currents that are involved in repair and regeneration.

Hans Nieper wrote that the electrical charge of the cell membrane is

maintained both by the structure of the membrane and its associated

minerals, but these minerals must be in the right location and at the

right concentration for optimisation of cellular potential and metabolic

activity. Mineral transporters serve the function of special delivery

vehicles placing minerals in optimal cellular and subcellular locations.

The length of the human blood vessel and capillary system has been

estimated to be between 40,000 and 50,000 kilometres. The heart pumps the

blood through such an immensely long system with relatively little power

because the blood particles move on an electromagnetic cushion, which

depends on the condenser structure of the cell membranes. A loss in this

will produce increased resistance, high blood pressure, more clotting,

deposits on the vessels and varicose veins. Over a period of 24 years, he

observed that for patients taking calcium and magnesium 2-AEP, the

development of thrombosis, circulation problems and high blood pressure

and the progression of varicose veins were almost entirely eliminated.

I tried 2-AEP capsules providing 300 mg of elemental calcium and 100 mg of

elemental magnesium daily in December 03. There was a sharp increase in

immune response, marked by left sinus constriction, nasal and bronchial

mucus, fatigue and some nausea. This started after about two hours and was

continuous except for an easing of sinus constriction during the night.

After 24 hours, strong, sustained pains began in those tissues that needed

to be kept warm to avoid chronic pain, particularly the legs from the

knees down and an area above the left shoulder blade. This was cold aching

requiring applied heat, it was continuous for three days and in the case

of my lower legs, was followed by a fresh crop of skin eruptions above the

sites of pain, indicating a release of toxins in excess of what could be

carried away by the blood. Increased levels of magnesium and calcium were

confirmed by greatly reduced tartar formation, slight queasiness, the

sensation around the roots of teeth referred to earlier and by the usual

lingering thirsty, soapy taste.

This was a process that I had been through many times before and the next

stage had always been epigastric discomfort and diarrhoea, but not this

time. After three days, the immune surge reduced to two or three hours

after each capsule, both calcium and magnesium. After five days, thirst

became excessive, there was some epigastric discomfort and I suspected

that the immune enhancement was turning to suppression. Reducing the

calcium to two capsules (100 mg each) daily, the minimum plateau dose for

immune response, eased these problems.

It seemed that since the immune boost and the greater GI tolerance of

magnesium were coming primarily from the calcium 2-AEP, the next step

would be to find the best form of magnesium to accompany it. I tried

taking one calcium 2-AEP and the orotates referred to previously, and then

two calcium and 100 mg magnesium first as glycinate and then as

unspecified aac. Presumably thanks to the calcium 2-AEP, the magnesium was

not laxative the way it was before but this dose was nevertheless hard to

tolerate. Immune response - left sinus constriction and tinnitus - was

good with the glycinate but resuming magnesium 2-AEP was easier to

tolerate and caused several hours of pains around and below my right knee.

There was also an immune boost that lasted two or three days, after which

my sinuses were clearer. Increased mucus and fatigue, and pains and skin

eruptions in my lower legs were still present after a month.

I went on to try magnesium malate and magnesium chloride fumarate. These

worked well and gave me no problems but there was a surge in tissue

activity in my lower legs - circulation, cycling pains and skin

eruptions - when I resumed magnesium 2-AEP. However, after two weeks at

100 mg daily, coldness and discomfort around and below my knees,

especially in bed, indicated the need for more magnesium. When I

substituted glycinate, there were a lot of cycling pains in my lower legs,

some of them strong and extensive, that lasted for about six hours and

also left sinus closure. It seems that because 2-AEP (magnesium and

calcium) produces thirst and mouth soreness, especially of the tongue,

just like other forms of magnesium, I mistook this for magnesium

abundance. I don't know whether the magnesium in magnesium 2-AEP has

benefits that I would not get from additional calcium 2-AEP plus another

form of magnesium and it remains to be seen whether the calcium 2-AEP is

providing enough calcium. However, for the time being, 100 mg magnesium as

2-AEP alternating with glycinate seems to work better than either on it's

own and the overdose from glycinate roughly balances the underdose from

the 2-AEP.

I should stress that calcium AEP is not necessarily a better way of

increasing absorption of calcium. The idea is to enable membrane channels

to admit more of other deficient elements, notably magnesium, into the

cells, because this is a major problem for many PWCFS and FMS.

Regarding phosphate deficiency, please remember that just as many of us

suffer from phosphate excess. In the same way, just as some individuals

might find that they benefit from reducing vitamin D levels, others, like

me, benefit from D supplementation.

Rob