Re: To all Dr. Cheney Patients/Inosine

[Guest guest]

since as i understand it, insoine is a component of isoprinosine,

shouldn't immunovir give us the same benefit as inosine?

here is a link that tells a little about isoprinosine's molecular

makeup:

http://www.rxmed.com/b.main/b2.pharmaceutical/b2.prescribe.html

thanks

bill

>

>

> To all Cheney patients,

>

> It appears from the article below that Inosine may be a cheap

replacement , and maybe more effective than Growth Factors.

>

> Dr. Cheney should read this ! I hoping one of you will

report back on what Dr. Cheney has to say about Inosine as a

replacement for GF's.

>

> Al

> --------------------------------------------------------------

------------------------------------------

> From : http://www.strokedoctor.com/new_break.htm

>

> NEW BREAKTHROUGHS IN STROKE AND BRAIN REPAIR

>

> Exciting new research shows that inosine, a safe and natural

nucleoside,

> can promote reorganization of the brain after a stroke and

improve the potential

> for recovery from paralysis! Friends, relatives and health

care professionals

> who are interested in brain repair should know about inosine.

>

> Neurons relay electrical messages throughout the brain and

spinal cord

> through a network of axons and dendrites. Axons lead away

from the neuron and

> dendrites are the receiving lines from other neurons. Dr.

Chen and Dr. Benowitz

> from Children's Hospital, Boston Massachusetts, demonstrated

that giving inosine

> to an animal with stroke can override factors that inhibit

axonal growth and

> increase axonal growth from the normal side of the brain to

the damaged side of

> the brain. The result was faster recovery! (1)

>

> Stroke affects about 700,000 people each year in the United

States. It is

> the third leading cause of death, after cardiovascular

disease and cancer, and

> is the leading cause of long term disability. Severe strokes

can cause

> devastating losses in speech, vision, comprehension, bowel

control, and motor

> function and it's an arduous and seemingly impossible battle

back to independent

> living for the patient and entire family. There is therefore

much excitement

> over the promise of using inosine as part of a standard

neurorehabilitation

> program.

>

> Inosine also plays a part in the regulation of energy

production in the

> cell's mitochondria. Inosine 5'-monophosphate is the

precursor of adenosine

> monophosphate, adenosine triphosphate (ATP) and guanosine

monophosphate (GMP).

> (10)

>

> When adenosine combines with three " energized " phosphate

molecules, it

> forms adenosine triphosphate (ATP), the high power molecule

that enables brain

> cells to repair themselves and to possibly even multiply!

>

> A cell loses its ATP if it becomes injured or lacking in

oxygen. This loss

> of ATP stimulates a series of events that leads to programmed

cell death

> (apoptosis). The optimum levels of ATP for cell function are

dependent on

> optimal amounts and ratios of oxygen, water, glucose, and

nutrients. A

> deficiency or imbalance in any of these factors can result in

tissue and organ

> injury. (5)

>

> Orally, Inosine has been the active ingredient in drugs used

in France and

> Russia to improve energy production in the heart. It has been

used for ischemia

> (lack of blood supply), cardiomyopathy (disease and injury to

the heart muscle)

> and arrythmia (abnormal heart beats). In 1975, Komarek and

associates showed

> that adenosine with inosine (a more stable metabolite)

increased coronary blood

> flow and reduced blood pressure and heart rate in dogs. (6)

>

> In cell culture studies, inosine can inhibit proinflammatory

cytokines

> such as tumor necrosis factor alpha, that plays a role in

programmed cell death.

> These anti-inflammatory effects may play a role in inosine's

anti-viral

> activity.

>

> Inosine as methyl inosine monophosphate improved mice

survival after

> exposure to influenza virus.(7) In other studies, inosine has

demonstrated

> anti-oxidative stress activity. (11)

>

> There are additional factors that make inosine a promising

treatment for

> brain repair. Nerve Growth Factor stimulates axon growth as

well the development

> of new neurons (neural stem cells). Inosine and/or Nerve

Growth Factor can

> override inhibitors (Rho genes) of axonal growth and may help

restore essential

> neural circuits after injury. (4)

>

> In 1999, Larry Benowitz and his colleagues published a report

that inosine

> was successful in stimulating extensive sprouting of axons

from intact pyramidal

> cells into areas of white matter in the rat spinal cord where

nerves had been

> cut (nerve lesion). (1)

>

> The most recent study by Chen, Benowitz and colleagues shows

inosine can

> compensate for stroke damage in rats by stimulating the

growth of lengthy axonal

> projections from intact neurons in one hemisphere into

sensorimotor areas of the

> damaged hemisphere. Behavioral tests included forelimb and

hindlimb placement

> (tests sensory input), head turning (tests basal ganglia

function), reaching for

> pellets (motor cortex integration), swimming tests (cortical

inhibition), and

> tongue protrusion tests (motor cortex). The inosine group

showed superior

> performance on all tests by day 7 and continued improving to

the end of the

> experiment. While the control group of rats returned to 50%

of their pre-stroke

> scores by 19 days, the inosine treated rats returned to near-

normal levels of

> performance by the 19th day. (2)

>

> Inosine is a natural substance with few adverse effects.

Since adenosine

> and inosine are broke down to the purine end-product, uric

acid, inosine

> supplements should not be used in those with a history of

gouty arthritis or

> hyperuricemia unless being monitored by a physician. Pregnant

women and nursing

> mothers should also avoid its use. (5, 12)

>

> Thus inosine may have significant therapeutic potential in

stroke, brain

> and spinal cord injury, and viral infections as well as a

wide range of

> neurological disorders, including degenerative and

demyelinating diseases.

> (2,3,8,9)

>

>

> References:

>

> (1) Benowitz, Larry et al. " Inosine stimulates extensive axon

collateral

> growth in the rat corticospinal tract after injury. "

Proceedings of the National

> Academy of Sciences, 1999, 96: 13486-13490.

>

> (2) Chen, Peng, Goldberg, Kolb, Marc Lanser, and

Larry

> Benowitz. " Inosine induces axonal rewiring and improves

behavioral outcome after

> stroke. " Proceedings of the National Academy of Sciences,

2002, 99(13):

> 9031-9036.

>

> (3) Ciccarelli, R. et al. " Involvement of astrocytes in

purine-mediated

> reparative processes in the brain. " International Journal of

Developmental

> Neuroscience, 2001, 19: 395-414.

>

> (4) D'Ambrosi, N. et al. " Interaction between ATP and nerve

growth factor

> signaling in the survival and neuritic outgrowth from PC12

cells. " Neuroscience,

> 2001; 108(3): 527-534.

>

> (5) Hendler, S. et al. (ed) " PDR for Nutritional

Supplements. " Medical

> Economics Co., Montvale, NJ, 2001.

>

> (6) Komarek, J. ad G.A. Parish. " The potentiation of the

activity of

> adenosine on coronary blood flow, blood pressure and heart

rate by inosine in

> the dog. " Arzneimittelforschung, 1975; 25(5): 737-40.

>

> (7) Masihi, N.K. and W. Hadden. " Protection by methyl

inosine

> monophosphate (MIMP) against aerosol influenza virus

infection in mice. "

> International Immunopharmacology, 2002, 2: 835-841.

>

> (8) McKeracher, . " Spinal cord repair: Strategies to

promote axon

> regeneration. " Neurobiology of Disease, 2001, 8: 11-18.

>

> (9) Neary, ph et al. " Trophic actions of extracellular

nucleotides and

> nucleosides on glial and neuronal cells. " Trends in

Neuroscience, 1996, 19:

> 13-18.

>

> (10)Torrecilla, Amparo et al. " Metabolic fate of AMP, IMP,

GMP and XMP in

> the cytosol of rat brain: an experimental and theoretical

analysis. " Journal of

> Neurochemistry, 2001; 76: 1291-1307.

>

> (11) Wakai, A. et al. " Inosine attenuates tourniquet-induced

skeletal

> muscle reperfusion injury. " Journal of Surgical Research,

2001, 99: 311-315.

>

> (12) Yamamoto, Tetsuya et al. " Effect of inosine on the plasma

> concentration of uridine and purine bases. " Metabolism, 2002,

51(4): 438-442

>

>

>

>

>

>

>

>

>

[Guest guest]

> since as i understand it, insoine is a component of isoprinosine,

> shouldn't immunovir give us the same benefit as inosine?

>

> > thanks

> bill

Hi Bill,

It should give the same benefit, but Imunovir is so much more

expensive than buying pure Inosine capsules as supplement. I don't

know how much Inosine is in Imunovir.

Inosine also can treat the peroxynitrite problem in CFS that Dr.

Pall has researched..

Al