Re: CFIDS, FM and Enteroviruses

[Guest guest]

Aren't enteroviruses a class of virus?

Adrienne

CFIDS, FM and Enteroviruses

Hi All.

I found this in the AARP Bulletin:

Researchers in France have found a probable cause for two painful

conditions that have long puzzled medical science.

They discovered traces of a virus in skeletal muscles of people with

chronic fatigue syndrome and fibromyalgia - but none in healthy

volunteers.

The virus, known as enterovirus, also turned up in people with

inflammatory muscle diseases, says Fatima Douche-Aourik of the

medical school at the University Hospital Center in Sainte-Etienne.

The researchers believe a persistent infection caused by the virus

may explain these conditions, according to their report in Vol. 71,

Issue 4 of the Journal of Medical Virology.

That's all I know, maybe somebody can find the Journal referred to.

Tom

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[Guest guest]

Hi Adrienne,

Here's the CDC site explaining enteroviruses:

http://www.cdc.gov/ncidod/dvrd/revb/enterovirus/non-polio_entero.htm

Sandy

" Adrienne Gomez " <duckblossm@c...> wrote:

> Aren't enteroviruses a class of virus?

> Adrienne

> CFIDS, FM and Enteroviruses

>

> Hi All.

> > I found this in the AARP Bulletin:

> > Researchers in France have found a probable cause for two painful

> conditions that have long puzzled medical science.

>

> They discovered traces of a virus in skeletal muscles of people with

> chronic fatigue syndrome and fibromyalgia - but none in healthy

> volunteers.

>

> The virus, known as enterovirus, also turned up in people with

> inflammatory muscle diseases, says Fatima Douche-Aourik of the

> medical school at the University Hospital Center in Sainte-Etienne.

>

>

>

>

>

>

>

>

[Guest guest]

here is the report from immuesupport.com:

http://www.immunesupport.com/library/showarticle.cfm/id/5285/searchtex

t/enterovirus/

Virus Seen in Muscle from Chronic Fatigue Syndrome Patients

ImmuneSupport.com

01-06-2004

By Will Boggs, MD

A persistent enterovirus infection in muscles may be to blame for

some cases of chronic fatigue syndrome (sometimes called

fibromyalgia) and others with chronic inflammatory muscle disease, a

French team reports.

They detected genetic material (specifically RNA) from enteroviruses

in 20 percent of muscle biopsies from patients with chronic

inflammatory muscle diseases and 13 percent of patients with

fibromyalgia/chronic fatigue syndrome, but not from healthy

volunteers.

The findings favor a persistent infection involving defective viral

replication as a cause of these conditions.

" The persistence of defective or infectious enteroviruses is well

established for a lot of organs, " Dr. Bruno Pozzetto from the

University Hospital Center of Saint-Etienne, France, told Reuters

Health.

Such infections have been documented in the heart, with possible

involvement in heart enlargement; in pancreatic cells, possibly

linked to juvenile diabetes; and in the central nervous system in

association with a syndrome that afflicts aging survivors of polio,

the researcher explained. " However, the link between these diseases,

as well as chronic inflammatory muscle diseases, and viral

persistence is not clear. "

Pozzetto and colleagues investigated the presence of enterovirus in

skeletal muscle biopsies from 15 patients with chronic inflammatory

muscle diseases, 30 patients with fibromyalgia/chronic fatigue

syndrome, and 29 healthy subjects to test their hypothesis that

skeletal muscle may play host to persistent enteroviral infection.

Three patients with chronic inflammatory muscle disease and four

patients with fibromyalgia/chronic fatigue syndrome were positive for

enterovirus RNA, the team reports in the Journal of Medical Virology.

None of the muscle biopsies in this study contained a particular

viral protein, the researchers note, which " suggests a defective

viral replication. "

It is too early to derive implications for treatment from these

results, Pozzetto said.

However, he noted that so-called sackie B viruses seem to play a

key role in persistent muscular infections. " To prevent this

persistence, an inactivated vaccine directed toward these viruses

could be indicated. "

Also, an antiviral agent called pleconaril, " acting during the early

phases of the viral cycle, could also be useful in muscular diseases

clearly associated with enterovirus. " This is being tried in some

cases of heart-muscle enlargement, Pozzetto said, but " it is too

early to answer for muscular diseases. "

SOURCE: Journal of Medical Virology, December 2003.

(Distributed by from Reuters news service).

[Guest guest]

Here's the abstract for that manuscript, I'll see if I can pull

pertinent info from the full version:

J Med Virol. 2003 Dec;71(4):540-7. Related Articles, Links

Detection of enterovirus in human skeletal muscle from patients with

chronic inflammatory muscle disease or fibromyalgia and healthy

subjects.

Douche-Aourik F, Berlier W, Feasson L, Bourlet T, Harrath R, S,

Grattard F, Denis C, Pozzetto B.

Laboratory of Bacteriology-Virology (GIMAP), Faculte de Medecine

Jacques Lisfranc, Saint-Etienne, France.

Enterovirus RNA has been found previously in specimens of muscle

biopsy from patients with idiopathic dilated cardiomyopathy, chronic

inflammatory muscle diseases, and fibromyalgia or chronic fatigue

syndrome (fibromyalgia/chronic fatigue syndrome).

These results suggest that skeletal muscle may host enteroviral

persistent infection. To test this hypothesis, we investigated by

reverse transcription-polymerase chain reaction (RT-PCR) assay the

presence of enterovirus in skeletal muscle of patients with chronic

inflammatory muscle diseases or fibromyalgia/chronic fatigue

syndrome, and also of healthy subjects.

Three of 15 (20%) patients with chronic inflammatory muscle

diseases, 4 of 30 (13%) patients with fibromyalgia/chronic fatigue

syndrome, and none of 29 healthy subjects was found positive.

The presence of VP-1 enteroviral capsid protein was assessed by an

immunostaining technique using the 5-D8/1 monoclonal antibody; no

biopsy muscle from any patient or healthy subject was found

positive.

The presence of viral RNA in some muscle biopsies from patients

exhibiting muscle disease, together with the absence of VP-1

protein, is in favor of a persistent infection involving defective

viral replication. Copyright 2003 Wiley-Liss, Inc.

> Hi All.

>

> I found this in the AARP Bulletin:

>

> Researchers in France have found a probable cause for two painful

> conditions that have long puzzled medical science.

>

> They discovered traces of a virus in skeletal muscles of people

with

> chronic fatigue syndrome and fibromyalgia - but none in healthy

> volunteers.

>

> The virus, known as enterovirus, also turned up in people with

> inflammatory muscle diseases, says Fatima Douche-Aourik of the

> medical school at the University Hospital Center in Sainte-Etienne.

>

> The researchers believe a persistent infection caused by the virus

> may explain these conditions, according to their report in Vol.

71,

> Issue 4 of the Journal of Medical Virology.

>

>

>

> That's all I know, maybe somebody can find the Journal referred to.

>

> Tom