Re: terperature swing

January 17, 2004

Temp goes up the more active you are-think football players who

need medical assistance when they become overheated. 'CFS' waxes

and wanes, and the more active you are when you feel better, the

higher your temp will be. IMHO only.

Mike C

In , " ms4runr2 " <ms4runr2@y...>

wrote:

> I've been tracking my temp for several weeks. It hovers in the 97

> degree range. I'm watching it to see if temp relates to the way I

> feel in terms of health. This morning I had an energy spell and was

> cleaning and just happened to take my temp and it was 99 degrees.

At

> first I thought it was because my health was improving; I just

> started taking Primal Defense and was wondering if a healthy colon

> would produce more heat. Maybe silly, but always grasping at

> straws... However, my temp. went back down to 97.5 after I cooled

> down from cleaning the floors. So did my energy. Anyway, I found

the

> whole thing strange. Why the high temp? Just from the exertion? A

> blood pressure raise from exertion? I'm not convinced that the

Primal

> Defense isn't doing something. It seems like so much of treatment,

> after attempts at dealing with symptoms, is aimed at clearing the

> biliary system, the liver. And it makes sense that the rest of the

> elimination system would be involved. Has anyone tried aiming at

> these systems extensively with any results? That's what I'm

planning

> on doing...

> /a

January 17, 2004

'CFS' waxes

and wanes, and the more active you are when you feel better, the

higher your temp will be. IMHO only.

Mike C

That was my experience exactly for a long time, but somehow, I have learned to

stop before activity turns into exertion, and I no longer get fevers like I used

to.

I don't know if it was exactly a learning process, really, or I just got to a

place where I tired so easily -and went back to bed- that I never got around to

the fever.

Thinking of it, during the long period when my usual mode was in and out of bed

a zillion times a day (do a little and rest, etc), I wouldn't get fevers from

that, only when I pushed ppast the fatigue and kept going. USed to use lots of

caffeine and Nutrasweet (usually diet coke),to push past.

Adrienne

January 19, 2004

Dear /a (ms4runr2),

Many PWCs have a low peripheral body temperature. This is to be

distinguished from the core body temperature (measured inside the

abdomen) which has been reported in a peer-reviewed published paper

to be normal.

The peripheral body temperature is normally maintained by heat

generated by the metabolism of the skeletal muscles. Therefore, low

peripheral body temperature is an indication that the skeletal

muscle metabolic rate is below normal.

The question is, why? And why does this metabolic rate sometimes

rise, producing a more nearly normal peripheral body temperature, as

you experienced?

According to my current hypothesis for the main subset of PWCs, the

lower metabolic rate in the red skeletal muscle cells results from a

depletion of glutathione there, which allows an increase in the

concentration of peroxynitrite, an oxidizing free radical.

Peroxinitrite is known to inhibit aconitase, an enzyme in the Krebs

cycle, and cytochrome oxidase, an enzyme in the respiratory chain.

Both the Krebs cycle and the respiratory chain are located in the

mitochondria of these cells, and they are used to burn food-supplied

fuels to produce ATP to power the muscle fiber contractions and the

housekeeping reactions in the cells. Heat is produced when ATP is

dephosphoryated to form ADP, and also from other reactions in the

cells. Thus, if these enzymes are inhibited, partial blockades are

inserted into the metabolism, and the heat production decreases,

thus reducing the peripheral body temperature.

It is my current belief that the glutathione status in the PWCs of

the main subset hovers on the ragged edge. Consequently, their

cells are operating like a neighborhood that is in a brown-out.

Anything that raises the glutathione level will increase the

metabolic rate of the red skeletal muscle cells, and will therefore

increase the available energy and the peripheral body temperature.

Conversely, anything that places an increased demand on the

glutathione supply will do the opposite. This includes any type of

stress, such as exertion, emotional stress, toxins, or attempted

increase in immune response to pathogens.

Raising the glutathione level can be done, but it is not always

easy, because there are vicious cycles and other impediments that

have come into play, and there seem to be more of them the longer

the PWC has been ill. For quite a while we have been discussing the

use of nondenatured whey protein products to raise glutathione, and

these serve to help many PWCs. We have also discussed Jeff 's

amino acid precursor mix for raising glutathione(www.cfsn.com). Dr.

Salvato in Houston pioneered the intravenous injection of

glutathione for PWCs, and more recently Drs. ,

Kane and Neil Speight have been using a fast IV push of glutathione

in their treatment protocol, as described in their book " The Detoxx

Book. " One person on the list has described the use of glutathione

suppositories from a compounding pharmacy, and others, including Dr.

n Whitaker, have described treatment of the lungs using

glutathione in a nebulizer.

I don't think we yet know all of the vicious cycles and other

impediments that can prevent the increase in glutathione in PWCs.

Mercury toxicity is certainly one of them. Various infections are

another category. Perhaps the low peripheral body temperature

itself, which causes massive production of norepinephrine to shut

down blood circulation in the skin in order to reduce further heat

loss, is another, because a breakdown product of noradrenaline

requires glutathione for it to be removed from the body.

I think this is the reason why the successful treatment of CFS

requires a more or less simultaneous, multipronged approach,

involving help to the gastroinsestinal system, supplying the raw

materials to build glutathione, improving general nutrition,

detoxification of toxins that have built up, combating the

infections, FIR heating to raise the peripheral body temperature,

and others. I have described this in the Strawman Treatment

Protocol, which can be found at my name in the Links section of this

list.

Rich