Cobamamide/co-enzyme B12/Dibencoside

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Hi all!

Does anyone have any information on cobamamide? Is it safe for us to use?Any

better or worse than hydroxycobalamin form?Any studies?

here is some info.

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The typical non-cyanocobalamin forms of vitamin B12 in supplemental forms are

methylcobalamin and adenosylcobalamin (also known as 5’-deoxyadenosylcobalamin,

dibencozide, coenzyme B12, cobamamide, and cobinamide). Calling adenoslcobalamin

“co-enzyme B12 " is someowhat misleading because methylcobalam is also a

co-enzyme from of B12. Hydroxocobalamin is the form typically used in B12

injections.

Some researchers question whether these non-cyanocobalamin supplements are

stable in their oral form. For this reason, much larger amounts are typically

used with hope that at least some are absorbed intact. One study suggests that

once absorbed, methylcobalamin may be retained in the body better than

cyanocobalamin.30

Notes for Introduction

1. Okuda K, Yashima K, Kitazaki T, Takara I. Intestinal absorption and

concurrent chemical changes of methylcobalamin. J Lab Clin Med. 1973

Apr;81(4):557-67.

Methylcobalamin in a Small Sample of Vegans

son1 (2000, USA) studied 3 vegans with elevated uMMA levels who were

treated with 1/2 to 1 sublingual methylcobalamin tablet (from Enzymatic Therapy,

Green Bay, WI), 2 times/day for 3 weeks. Correspondence with the author (March

21, 2002) verified that these tablets contain 1,000 µg methylcobalamin each.

Two of the subjects’ urinay MMA normalized while the remaining subject’s stayed

slightly elevated at 4.1 µg/mg creatinine (normal is < 4.0 µg/mg creatinine).

Thus, at a rate of 1-2,000 µg/day, methylcobalamin appears to be absorbed at a

high enough rate to improve B12 status in some vegans. Additionally, this

indicates that the methylcobalamin was able to improve the MMA pathway which

requires adenosylcobalamin (in other words, methylcobalamin was apparently

converted into adenosylcobalamin in these people).

Notes for Methylcobalamin in a Small Sample of Vegans

1. son MS. Metabolic vitamin B12 status on a mostly raw vegan diet

with follow-up using tablets, nutritional yeast, or probiotic supplements. Ann

Nutr Metab. 2000;44(5-6):229-34.

Therapeutic Use of Coenzyme Forms of B12

The coenzyme forms of B12 appear to be more effective in treating certain

conditions than is cyanocobalamin (though they are often injected rather than

taken orally). 1 (1997) reviewed the research on supplementing with the

coenzyme forms of B12 (methylcobalamin and adenosylcobalamin). Results of

studies performed on humans are listed here:

Conditions Reported to Improve by Coenzyme Forms of B12

Therapeutic dose recommended by 1 Conditions reported to improve

from treatment1,A

Methylcobalamin 1500-6000 µg/day Diabetic neuropathy

Infertility

Hyperhomocysteinemia in diabetes

Sleep disordersB

Bell’s Palsy

Adenosylcobalamin, aka:

5’-deoxyadenosylcobalamin, dibencozide, coenzyme B12, cobamamide, and

cobinamide 1000-6000 µg/day Neurological problems secondary to anorexia

Hepatitis A

Viral hepatitisB

A – In many cases, treatment was not compared to cyanocobalamin

B - More effective than cyanocobalamin

Notes for Hydroxocobalamin

1. G. The co-enzyme forms of vitamin B12: Toward an understanding of

their therapeutic potential. Alt Med Rev. 1997;2(5):459-471.

Hydroxocobalamin

Hydroxocobalamin is the form of B12 typically found in food. There are not many

oral forms for people to take; it is normally injected. One study suggests that

after injections, hydroxocobalamin is retained in the body better than

cyanocobalamin.1

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And here is another site giving info

http://www.thorne.com/altmedrev/fulltext/b122-6.html

Thanks very much.

Nil