Magnesium forms --personal breakthrough -- Rich

[Guest guest]

Hi,

I did alittle search and the best prices that I found so far for Ca 2-

AEP and Mg 2-AEP are through //www.yournutritionshop.com.

If someone finds better prices let us know.

This website also ships worldwide and the shipping cost by " Royal

Airmail " is decent.

Nat

[Guest guest]

Rita, basic Labcorp, so we can guess probably outside of cell, right?

In a message dated 12/13/03 4:49:02 PM Eastern Standard Time,

writes:

, did your test measure mg outside or inside the cell? I have not been

tested at all, but a friend told me, who was tested for MG in the cell, that

who she consults with finds that often there are normal values of MG around the

cell but a severe deficientcy inside the cell. I have no personal knowledge

about this though. Rita

[Guest guest]

If you find time to look into this, Rich, you might want to point out that

Nieper's theories were regarded as speculative, though of course that

doesn't affect the question of the value in practice of his mineral

transporters.

In the next version of the notes, I addressed this and a few techical

inaccuracies. Below are the first two (revised) paragraphs.

Rob

Mineral Transporters

There are a number of these. The pioneer in their clinical use was Hans

Nieper, who, although his theories were regarded by the medical

establishment as grounded in an incomplete grasp of physics and

insufficiently supported by objective studies, treated many thousands of

patients with apparently good results. Despite repeated efforts by the FDA

to ban Nieper's supplements, many patients continue to experience

benefits, the largest single group being MS sufferers. In his view,

orotates are bound to orotic acid and carry minerals through the cell

membrane to intracellular structures like the mitochondria. Aspartates are

bound to the amino acid aspartic acid and carry minerals to the inner

layer of the outer cell membrane, potassium and magnesium aspartates being

highly regarded for cardiovascular problems. Of particular interest to me

is 2-AEP.

2-AEP

This form of calcium, magnesium and other minerals is a complex subject

not made easier by the lack of agreement on terminology. It is believed to

carry minerals to the outer layer of the outer cell membrane and is known

in German literature as membrane integrity factor or vitamin Mi, and in

English literature as colamine phosphate salts or phosphonates. To take

the case of calcium, it is known as calcium 2-aminoethyl phosphate

or -aminoethylphosphonic acid (Ca 2-AEP) or calcium ethanolamine phosphate

ester (Ca EAP-2) and there are other versions of these names. Here, I use

2-AEP, which is the most common abbreviation, though the UK products that

I use are called EAP2.

[Guest guest]

Rob,

I'm glad to hear of your success with this form of Ca and Mg. This

is new to me, and I don't see anything about it in recent

biochemistry texts, so I'll have to dig a little deeper.

Rich

> Rich and group,

>

> We've discussed several times in the past the problem of deficient

> absorption and retention of magnesium among PWC and PWFMS. For some

> reason, many find it impossible to achieve normal cellular levels.

> Cheney has noted this phenomenon and puzzled over it but has not

found a

> solution. It is a very big therapeutic problem.

>

> I've been struggling with it continuously for about 15 years. It's

the

> only area of nutrition that I have been unable to optimise --

until now!

>

> Following hints from research papers that the problem might lie in

> cellular membranes, I've been looking for a mineral transporter

that could

> deliver the mineral to this site. I've just written up some notes

and as

> usual, here are they are. Unusually for me, however, they include

some

> phrases that I have borrowed without fully understanding. The

reason is

> that it is a difficult subject and I am dependent on others, so I

would

> welcome any comments and criticisms. The benefits to me, however,

are

> unquestionable and I feel I ought to share the information.

>

> Mineral Transporters

> There are a number of these. Orotates are bound to orotic acid and

carry

> minerals through the cell membrane to intracellular structures like

> mitochondria. Magnesium orotate is particularly highly regarded.

> Aspartates are bound to the amino acid aspartic acid and deliver

minerals

> to the outer layer of the inner cell membrane. Arginates are bound

to the

> amino acid arginine and can penetrate the cell and deliver the

mineral to

> the plasma and inner layer of the outer cell membrane. There are

others

> too, including the colamine phosphates or 2-AEP.

>

>

>

> 2-AEP

> This form of calcium and also magnesium and other minerals is a

complex

> subject not made easier by the lack of agreement on terminology.

The

> pioneer of therapeutic use of 2-AEP was Hans Nieper. It is known

in German

> literature as membrane integrity factor or vitamin Mi, and in

English

> literature as colamine phosphate salts or, to take the case of

calcium, as

> calcium 2-aminoethyl phosphate (Ca 2-AEP) or calcium ethanolamine

> phosphate ester (Ca EAP-2). There are also several variant forms.

Here, I

> use 2-AEP, which seems to be the most common, though the UK

products that

> I use are called EAP 2.

>

>

>

> Ca 2-AEP is an essential factor for cell membrane integrity. It

binds

> fatty acids and electrolytes to the cell membrane structure that

generates

> the cell's electrical charge. Studies have shown that Ca 2-AEP is

> essential for neurotransmission, nerve impulse generation, and

muscular

> contractions. Among its functions are the following.

>

>

>

> a.. Cells allow entry of vital nutrients through pores spread

across the

> cellular membrane. Two types of pores predominate: free lipid

pores and

> peptide-lined transport pores. Lipid pores can permit the unwanted

> penetration into cells by harmful agents. Ca 2-AEP helps to seal

the lipid

> cellular membrane pores of the outer cell membrane, against

unwanted

> substances - toxins, bacteria, viruses, antibodies and other

harmful

> agents.

> b.. It facilitates the cellular exchange of inorganic

electrolytes and

> aids the absorption of nutrient substances such as fatty acids,

amino

> acids, carbohydrates, vitamins, hormones and steroids through

the 'active

> transport pores' of cell membranes.

> c.. It helps the cells to retain the electrical charges of

calcium,

> potassium and magnesium ions residing on the membrane surface

where they

> serve to increase the conductivity of nerve tissue. It does this by

> causing calcium and other minerals to bind to cellular membranes

where

> they serve as electrical condensers, essential for cellular

regulation.

> This condenser function of the cell membrane plays an active role

in

> disease prevention. If there is an insufficient amount of colamine

> phosphate salts, the cell's electrical charge and condenser

function will

> be abnormal. A significant loss of the electrical charge of the

cell

> membrane may have grave consequences for the circulatory, immune

and

> neuromuscular systems.

>

>

> Living cells have a membrane potential of about -70mV. In healthy

tissue

> the inside of the cell is negative relative to its external

surface, but

> when tissues are injured, sodium and water flow in to the cells and

> potassium, magnesium and zinc are lost from the cell interior. The

change

> in mineral content of the cell is one of the major factors causing

injured

> cells to have lower membrane potential. A healthy cell membrane

potential

> is strongly linked to the control of cell membrane transport

mechanisms as

> well as DNA activity and protein synthesis, so injured cells,

which cannot

> maintain normal membrane potential, will have electronic

dysfunction that

> will impede repair and rejuvenation processes. A key component of

repair

> and rejuvenation is to re-establish a healthy membrane potential.

>

>

>

> Some of the most important factors implicated in musculoskeletal

repair

> and regeneration involve natural electrical properties of the

body's

> tissues and cells, such as cell membrane potential (capacitance)

and

> protein semiconduction of electricity. The body utilises these

fundamental

> bioelectric features to produce electrical currents that are

involved in

> repair and regeneration.

>

>

>

> Hans Nieper wrote that the electrical charge of the cell membrane

is

> maintained both by the structure of the membrane and its associated

> minerals, but these minerals must be in the right location and at

the

> right concentration for optimisation of cellular potential and

metabolic

> activity. Mineral transporters serve the function of special

delivery

> vehicles placing minerals in optimal cellular and subcellular

locations.

> The length of the human blood vessel and capillary system has been

> estimated to be between 40,000 and 50,000 kilometres. The heart

pumps the

> blood through such an immensely long system with relatively little

power

> because the blood particles move on an electromagnetic cushion,

which

> depends on the condenser structure of the cell membranes. A loss

in this

> will produce increased resistance, high blood pressure, more

clotting,

> deposits on the vessels and varicose veins. Over a period of S24

years, he

> observed that for patients taking calcium and magnesium 2-AEP, the

> development of thrombosis, circulation problems and high blood

pressure

> and the progression of varicose veins were almost entirely

eliminated.

>

>

>

> I tried 300 mg of Ca 2-AEP and 100 mg of Mg 2-AEP daily in

December 03.

> There was a very marked and quite unexpected increase in immune

response,

> marked by left sinus constriction, nasal and bronchial mucus,

fatigue and

> some nausea. Many other supplements have produced this and some

more

> intensely, but only for a short time. This started after maybe two

hours

> and was continuous except for the usual easing of sinus

constriction

> during the night. After 24 hours, strong and sustained pains in

those

> tissues that needed to be kept warm to avoid chronic pain,

particularly

> the legs from the knees down and an area above the left shoulder

blade,

> began and continued strongly - a sure sign that magnesium levels

were

> rising enough to start normalising metabolism. Increased levels of

calcium

> and magnesium were confirmed by an elimination of tartar formation

and by

> the usual thirsty, soapy taste in the mouth, though not by a

greatly

> increased need for water.

>

>

>

> This was a process that I had been through many times before and

the next

> stage had always been epigastric discomfort and diarrhoea, but not

this

> time -- not at all. The immune response eased after 48 hours and

my energy

> levels were significantly higher than before.

>

>

>

> Rob

[Guest guest]

> Following hints from research papers that the problem might lie in

> cellular membranes, I've been looking for a mineral transporter

that could deliver the mineral to this site. There are others

> too, including the colamine phosphates or 2-AEP.

> This form of calcium and also magnesium and other minerals is a

complex

> subject not made easier by the lack of agreement on terminology. The

> pioneer of therapeutic use of 2-AEP was Hans Nieper.

Bob:

Rob as you, or someone said, the FDA made companies quit selling the

Hans Nieper 2-AEP Cal, Mag and Pot because they made claims that it

could possibly cure cancer. I did a search and all companies who did

sell it said on their website that they were out of it. I found a

company in NM who had 8 bottles of the 2-AEP comples (had all three

of the minerals). I only bought two of them to see if they worked. I

started taking them friday so too soon to tell. One thing I did read

in my research was the 2-AEP calcium can repair cellular membrane!

Isn't that what Kane is saying and treating? If could do

that it would be so much cheaper and easier. If it does work, now I

have to find it in Canada, off-shore or somewhere.

Bob Harrington