FW: orotic acid (calcium orotate)

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Terry Suttles

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Orotic Acid (vitamin B13)

Description: Orotic acid (vitamin B13) is manufactured by the body by

intestinal flora. Orotic acid (vitamin B13) facilitates the transport of

minerals across the cell membranes in your body, thus making these minerals

optimally bio-available.

Metabolic supplementation with orotic acid and magnesium orotate.

Rosenfeldt FL.

Orotic acid (OA), a naturally occurring substance, is a key intermediate in

the biosynthetic pathway of pyrimidines. Previous investigations in the

heart suggest that orotate can protect recently infarcted hearts against a

further ischemic stress and may be beneficial in certain types of

experimental cardiomyopathy. At the Hamburg symposium on magnesium orotate,

a number of studies of this form of metabolic supplementation were presented

that indicate orotic acid and its magnesium salt have a modest beneficial

effect on the myocardium under conditions of stress ranging from myocardial

infarction to severe physical exercise. The following conclusions can be

drawn: (1) Orotic acid can improve the energy status of the recently

infarcted myocardium (rat hearts). (2) Orotic acid may improve myocardial

purine and pyrimidine levels by stimulating hepatic release of uridine into

the bloodstream, which in turn augments depleted myocardial pyrimidines and

purines (rat heart). (3) Orotic acid improves the tolerance of the recently

infarcted heart to global ischemia (rats). (4) Magnesium orotate may reduce

the severity of chronic myocardial dysfunction and structural damage in

cardiomyopathy (cardiomyopathic hamsters). (5) Magnesium orotate may improve

exercise tolerance in patients with coronary artery disease and in trained

athletes (humans). (6) Magnesium orotate has only a weak inotropic effect,

if any, on normal hearts (rats). (7) Further clinical testing is indicated

to determine if the effects described could be of significant clinical

benefit in the treatment of heart disease.

Publication Types:

Congresses

Editorial

PMID: 9794088 [PubMed - indexed for MEDLINE]

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