Ynt: Klonopin and immune system--a and Doris

[Guest guest]

I have history of using long term usage of Marplan,MAO inibator..I am

suspicious that it might have contributed to my illness..

See below link.

http://www.holistic-online.com/Remedies/CFS/cfs_drugs_causing_CFS.htm

Nil

Re: Klonopin and immune system--a and Doris

| > Immunomodulatory effect of ligands active at the peripheral

| > benzodiazepine receptor (PBR) was examined in human peripheral blood

| > mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed

| > phytohemagglutinin (PHA) and concanavalin A (ConA) induced

| > proliferation of PBMC. All three ligands inhibited interleukin-3-

| > like activity (IL-3-LA) secretion, while the production of

| > interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only.

| > The selective central benzodiazepine ligand clonazepam did not

| > affect the cellular immune functions examined. Our results indicate

| > an in-vitro immuno-suppressive activity of peripheral and mixed, but

| > not central type benzodiazepine ligands. "

|

| Rich,

|

| Bringing up this connection is interesting. I'm wondering now about how

widely used Valium was (isn't that a shorter acting benzo?) back in the

60's? and 70's? I think it was. I was rx'd Valium a

| few yrs before I came down with full blown CFS. I was under unbelievable

stress from a bad marraige and job at the same time and had to go to the ER

for hyperventilating and my hands were numb.

| They rx/d 6 MONTHS worth of valium (take 3 times a day) right then and

there. Well, of course it totally doped me so bad I couldn't even move so I

did not take it that long or that often, but now I

| have to wonder if using the benzo's PRIOR to CFS could have been a

contributing factor by suppressing the immune system? Does anyone else have

a history of benzo's prior to CFS? You notice Valium

| isn't used nearly as much anymore.

|

| Marcia

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discussed here, please consult your doctor.

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