Multi-dose vials require a preservative to prevent microbial contamination

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Statement of American Journal of Pediatrics in 2000

Other vaccines such as diphtheria-tetanus, meningococcal, and influenza

vaccines will still contain thimerosal after the first quarter of 2001.

Diphtheria-tetanus (DT) and meningococcal vaccines are not recommended for

children as part of the recommended childhood immunization schedule.

Influenza vaccine is not recommended routinely for infants under 6 months of

age, but should be given to infants and children 6 months of age and older

who are at high risk of morbidity and mortality from the influenza virus.

Continued use of these products as indicated is recommended until thimerosal

is removed or until new products without thimerosal are licensed.

The vaccination of children in much of the world will continue to require

the use of multi-dose vials for reasons of cost, production, and storage

capacity. Multi-dose vials require a preservative to prevent microbial

contamination after the vial is opened. While thimerosal is currently the

preferred preservative, manufacturers are encouraged to seek alternatives.