Re: cortisol and Hippocampus

[Guest guest]

> Could this be why we have memory problems?

>

> http://sln.fi.edu/brain/stress/cortisol.html

> Nil

Nil,

Thanks for posting this. Looks like it could be part of the puzzle.

I plan to study it.

Rich

[Guest guest]

thanks Nil... the link in your posting

http://sln.fi.edu/brain/stress/cortisol.html

It lead onto another site called the Human Brain .. the lin Institute

which is very useful... i would thoroughly recommend the Human Brain Site...

the are many good points in there which relate directly to how the brain

controls hormones and how we can affect our health by how we think.

Interested to know if others find this useful.

[Guest guest]

Hi Rich and All,

I would love to find a natural substance

that could

suppress cortisol so as to be able to have a better functioning brain

and body. Any ideas?

Thanks

Mike

[Guest guest]

I was just searching for that.

found this

http://www.dadamo.com/napharm/store3/template2/cortiguard.htm

I also read somewhere else that high doses of B1/B6 combination also

suppresses HPA axis activity. Not tried yet!

Nil

Re: Re: cortisol and Hippocampus

| Hi Rich and All,

| I would love to find a natural substance

| that could

| suppress cortisol so as to be able to have a better functioning brain

| and body. Any ideas?

|

| Thanks

|

| Mike

|

|

|

|

| This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

|

|

[Guest guest]

> Hi Rich and All,

> I would love to find a natural substance

> that could

> suppress cortisol so as to be able to have a better functioning

brain

> and body. Any ideas?

>

>

Thanks

>

> Mike

Mike,

Do you know for sure that your cortisol level is elevated? The

reason I ask is that I think that cortisol is elevated in the early

stages of CFS, in response to a combination of various types of

stress, but according to measurements in several PWCs, it appears

that cortisol output is frequently found to below normal later on in

the illness, and also often varying in phase from its normal daily

cycle.

Rich

[Guest guest]

Hey Rich,

An additional research area is the effects of CRH output in response

to stress in CFS, but more of interest would be the effects of CRH

output in the environment of blunted cortisol output. Since these

two are interwoven in the negative feedback loop, if cortisol is in

fact blunted, then maybe it isn't able to adequately provide the

negative feedback, and thus there is CRH flooding the body,

especially under additional stressors. Possibly it is the CRH that

cause the brain symptoms, not actually the cortisol. Just food for

thought and research.

Mark

> > Hi Rich and All,

> > I would love to find a natural

substance

> > that could

> > suppress cortisol so as to be able to have a better functioning

> brain

> > and body. Any ideas?

> >

> >

> Thanks

> >

> > Mike

>

> Mike,

>

> Do you know for sure that your cortisol level is elevated? The

> reason I ask is that I think that cortisol is elevated in the early

> stages of CFS, in response to a combination of various types of

> stress, but according to measurements in several PWCs, it appears

> that cortisol output is frequently found to below normal later on

in

> the illness, and also often varying in phase from its normal daily

> cycle.

>

> Rich

[Guest guest]

I read that CfS people had inadaquate amounts of CRH secretion in their

bodies. I don't have the link now but it was at one of the Goldstein's

reports. How does that sound to you? Could this be correct? For which level

of the illness? I would think for the last level. Thanks.

Nil

Re: cortisol and Hippocampus

| Hey Rich,

| An additional research area is the effects of CRH output in response

| to stress in CFS, but more of interest would be the effects of CRH

| output in the environment of blunted cortisol output. Since these

| two are interwoven in the negative feedback loop, if cortisol is in

| fact blunted, then maybe it isn't able to adequately provide the

| negative feedback, and thus there is CRH flooding the body,

| especially under additional stressors. Possibly it is the CRH that

| cause the brain symptoms, not actually the cortisol. Just food for

| thought and research.

| Mark

|

|

|

|

|

|

|

| > > Hi Rich and All,

| > > I would love to find a natural

| substance

| > > that could

| > > suppress cortisol so as to be able to have a better functioning

| > brain

| > > and body. Any ideas?

| > >

| > >

| > Thanks

| > >

| > > Mike

| >

| > Mike,

| >

| > Do you know for sure that your cortisol level is elevated? The

| > reason I ask is that I think that cortisol is elevated in the early

| > stages of CFS, in response to a combination of various types of

| > stress, but according to measurements in several PWCs, it appears

| > that cortisol output is frequently found to below normal later on

| in

| > the illness, and also often varying in phase from its normal daily

| > cycle.

| >

| > Rich

|

|

|

| This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

|

|

[Guest guest]

> Hey Rich,

> An additional research area is the effects of CRH output in

response

> to stress in CFS, but more of interest would be the effects of CRH

> output in the environment of blunted cortisol output. Since these

> two are interwoven in the negative feedback loop, if cortisol is in

> fact blunted, then maybe it isn't able to adequately provide the

> negative feedback, and thus there is CRH flooding the body,

> especially under additional stressors. Possibly it is the CRH that

> cause the brain symptoms, not actually the cortisol. Just food for

> thought and research.

> Mark

Mark,

I still have a lot to learn about the behavior of the HPA axis in

CFS. My understanding is that in many cases the adrenal glands in

PWCs would function properly if they received the appropriate ACTH

stimulation from the pituitary, which depends on the appropriate

secretion of CRH by the hypothalamus, but that the hypothalamus is

not putting out CRH as it should. The result is that the adrenals

actually shrink in size, for lack of stimulation. I think there was

a study that showed they could be half normal size in some cases.

Efforts to treat this by giving corticosteroid hormones have not been

very successful, apparently because this does not match the level of

corticosteroids to the variation in stress experienced by the body.

I think this is what Dr. Cheney means by lack of proper dynamic

response. The important thing seems to be that the operation of the

hypothalamus has to be fixed. Perhaps this is where the growth

hormone and growth factors treatment comes in.

On the other hand, there are those who talk about adrenal exhaustion,

which I take to mean that the adrenals have been overdriven for so

long by stress-stimulated CRH and ACTH secretion that they are no

longer able to repond properly by secreting cortisol. In this case,

perhaps treating with low level corticosteroids or adrenal extracts

might allow the adrenals to rest, so that they would then be able to

function normally again.

I think there are others whose circadian rhythm for cortisol

secretion has become out-of-phase with or even completely

desynchronized from the sun's day/night cycle. I'm not sure what

causes this.

I think it's important to determine which is the situation in a

particular case, in order to know how to properly treat it. As I

say, I don't think I have a very good grasp of this whole HPA axis

subject in CFS.

Rich

[Guest guest]

I am dealing with these glands in the brain structurally through neuro

cranial restucturing. One might get results through cranial sacral work or

osteopathic manipulation. I have had some solid results in energy

improvement and shifting to a daytime schedule. If you are interested

interview practitioners to find one that sees the connections to you

condition.

Re: cortisol and Hippocampus

> Hey Rich,

> An additional research area is the effects of CRH output in

response

> to stress in CFS, but more of interest would be the effects of CRH

> output in the environment of blunted cortisol output. Since these

> two are interwoven in the negative feedback loop, if cortisol is in

> fact blunted, then maybe it isn't able to adequately provide the

> negative feedback, and thus there is CRH flooding the body,

> especially under additional stressors. Possibly it is the CRH that

> cause the brain symptoms, not actually the cortisol. Just food for

> thought and research.

> Mark

Mark,

I still have a lot to learn about the behavior of the HPA axis in

CFS. My understanding is that in many cases the adrenal glands in

PWCs would function properly if they received the appropriate ACTH

stimulation from the pituitary, which depends on the appropriate

secretion of CRH by the hypothalamus, but that the hypothalamus is

not putting out CRH as it should. The result is that the adrenals

actually shrink in size, for lack of stimulation. I think there was

a study that showed they could be half normal size in some cases.

Efforts to treat this by giving corticosteroid hormones have not been

very successful, apparently because this does not match the level of

corticosteroids to the variation in stress experienced by the body.

I think this is what Dr. Cheney means by lack of proper dynamic

response. The important thing seems to be that the operation of the

hypothalamus has to be fixed. Perhaps this is where the growth

hormone and growth factors treatment comes in.

On the other hand, there are those who talk about adrenal exhaustion,

which I take to mean that the adrenals have been overdriven for so

long by stress-stimulated CRH and ACTH secretion that they are no

longer able to repond properly by secreting cortisol. In this case,

perhaps treating with low level corticosteroids or adrenal extracts

might allow the adrenals to rest, so that they would then be able to

function normally again.

I think there are others whose circadian rhythm for cortisol

secretion has become out-of-phase with or even completely

desynchronized from the sun's day/night cycle. I'm not sure what

causes this.

I think it's important to determine which is the situation in a

particular case, in order to know how to properly treat it. As I

say, I don't think I have a very good grasp of this whole HPA axis

subject in CFS.

Rich

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Can anyone explain me what cranial sacral work is or give me a link that

has a good explanation of what it is. I made a search at web but still could

not understand what it is.Is it energy work? or is it mechanical?

Thanks.

Nil

RE: Re: cortisol and Hippocampus

| I am dealing with these glands in the brain structurally through neuro

| cranial restucturing. One might get results through cranial sacral work or

| osteopathic manipulation. I have had some solid results in energy

| improvement and shifting to a daytime schedule. If you are interested

| interview practitioners to find one that sees the connections to you

| condition.