Zinc protection of mercury-induced hepatic toxicity in mice

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Biol Pharm Bull 2000 Mar;23(3):305-8 Related Articles, Books

Zinc protection of mercury-induced hepatic toxicity in mice.

Afonne OJ, Orisakwe OE, Ndubuka GI, Akumka DD, Ilondu N.

Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe

University, Nnewi, Anambra State, Nigeria.

The actions and interactions of heavy metals on certain organ functions have

been of concern, since occupational exposure to certain

metals results in impairment of functions. Studies were carried out to determine

the effects of zinc (Zn) and mercury (Hg) on murine

liver. CD-1 male mice were administered 4 ppm HgCl2, 800 ppm ZnCl2, 4 ppm

HgCl2+800 ppm ZnCl2 or deionized water in their drinking

water for 12 weeks. Histological evaluation of the liver confirmed the toxic

effects of Hg, as well as the normal morphology of the

Zn-exposed animals. A combined treatment of both metals resulted in protection

of the Hg-induced liver damage by Zn. The results of

this experiment indicate that Hg has a toxic effect on liver, while Zn has a

protective action against such toxic effects.