Intracellular calcium ions in FMS

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[CO-CURE] RES: Role of intracellular calcium ions in the

physiopathology of FMS

> Role of intracellular calcium ions in the

> physiopathology of fibromyalgia syndrome.

>

> Boll Soc Ital Biol Sper 2000 Jan-Feb;76(1-2):1-4

>

> Magaldi M, Moltoni L, Biasi G, Marcolongo R.

>

> Institute of Rheumatology, University of Siena,

> Policlinico Le e, Viale Bracci 1, I-53100 Siena.

>

> PMID: 11449822

>

> Calcium ions have a key role in the physiology of

> muscular contraction: changes in calcium ion

> concentration may be involved in the pathogenesis of

> fibromyalgia. Although the plasmatic level of calcium

> in fibromyalgia patients is always in the normal

> range, it seemed interesting to evaluate the

> intracellular calcium concentration.

>

> The study was carried out on two groups of subjects:

> 70 affected by fibromyalgia and 40 healthy controls.

>

> The results obtained show that in fibromyalgia

> patients the intracellular calcium concentration is

> significantly reduced in comparison to that of healthy

> controls: the reduced intracellular calcium

> concentration seems to be a peculiar characteristic of

> fibromyalgia patients and may be potentially

> responsible for muscular hypertonus.

>

> The effective role of this anomaly in the

> physiopathology of fibromyalgia and the potential role

> of drugs active on the calcium homeostasis are still

> to be confirmed.

>

>

>

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