Guest guest Posted August 2, 2001 Report Share Posted August 2, 2001 > We will be starting on TMG next week. I'm just wondering if any > of you use this. I will copy my reply here from the other list. I tried TMG with two of my children with language delays. I had heard it really helps some kids with language. But with my kids, one of them got sooooo sick I thought I would have to take him to the hospital. I started on 1/2 the recommended dose, but I stopped after two days. Then the next week I tried again, at 1/4 the recommended dose, same problems. So I would recommend you start with a very small dose, like 1/4 the recommended dose, just to be sure your child can tolerate it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2001 Report Share Posted August 2, 2001 Hi Dana, what about DMG? I am trying DMG with my son , who is non-verbal. He was saying about 100 words between the ages of 1 and 4 but then gradually lost them all. He is now 8 years old. I would be interested in hearing from anyone who tried DMG. (Pickering, Ontario) danaatty@yah oo.com 08/02/2001 cc: (bcc: /TOR/NorthAmerica/MCKINSEY) 10:58 AM Subject: [ ] Re: TMG Please respond to enzymesandau tism > We will be starting on TMG next week. I'm just wondering if any > of you use this. I will copy my reply here from the other list. I tried TMG with two of my children with language delays. I had heard it really helps some kids with language. But with my kids, one of them got sooooo sick I thought I would have to take him to the hospital. I started on 1/2 the recommended dose, but I stopped after two days. Then the next week I tried again, at 1/4 the recommended dose, same problems. So I would recommend you start with a very small dose, like 1/4 the recommended dose, just to be sure your child can tolerate it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2001 Report Share Posted August 2, 2001 I would be > interested in hearing from anyone who tried DMG. > I tried DMG, the little tablets that dissolve under the tongue or in your mouth, and my older son reacted very badly. I tried it 3 different times. His reaction is a noticeable pathetic whining and wailing like a wounded animal. Younger son didn't react positive or negative. My kids always had language so that may be one reason it wasn't needed. But keep an eye open. Some kids who react to the DMG do better on the TMG and vice versa. . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2001 Report Share Posted August 2, 2001 > > Hi Dana, what about DMG? I am trying DMG with my son , who is > non-verbal. He was saying about 100 words between the ages of 1 and 4 but > then gradually lost them all. He is now 8 years old. I would be > interested in hearing from anyone who tried DMG. I never tried DMG so I don't know. But because of my one child's reaction to TMG, I would not want to consider the DMG. I would just recommend you give about 1/4 dose at first, and then work up if your son tolerates it. Then give it for about a month, to see if your son would benefit from it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2001 Report Share Posted August 8, 2001 My son sounds a lot like yours. He is on Thera Nu Condensed (close to SuperNu Thera, but a lot less powder to get down a 2 year old), Peptizyde and Zyme Prime. I have ordered the TMG liquid w/folic acid and B12. I hope the liquid goes into milk etc, as I know he won't take anymore syringes full of yucky stuff. He already has enough of those! I won't start the TMG for a couple weeks however, I want him to be on enzymes for a while first. I also have a RX for Nystatin I have to work in somewhere too. Ugh. Too many things to try. Poor little fella, I hope none of this stuff hurts my little boy. Let me know how you are doing! Becky > We will be starting on TMG next week. I'm just wondering if any > of you use this. Our DAN dr. said that with most kids, words starts > coming after they're on TMG. That makes me a little excited! He is > taking EnzymAid & SuperNuThera now. Tomorrow I will start him on EFA > powder...I have no idea how am I going to put that in his food! > > Anyway, any info about these stuff would be great! > > TIA, > yhen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2001 Report Share Posted August 8, 2001 We have on both P5P and TMG. The two seem to work together very well for . He was non verbal until three days after stopping dairy products when he identified four numbers verbally in front of my 'very negative to the diet' mother who nearly died of shock!! Now of course she is completely converted having nearly had me locked away for insanity! We then put on P5P to start with and found his speech increased quite a lot. Once we added TMG with folic acid, about a month later, we saw such a change in him. It is certainly not just speech but EVERYTHING. His eye contact, his awareness to the world, his humour, his concentration etc etc. When we ran out of TMG the other week it was horrendous and we are under no doubt that the TMG works for him. We also made a daily log to record improvements. This has played an important part in his official diagnosis which he received last week. One tip I would give anyone starting on P5P or TMG is take it slowly. We only added 1 ml every few days until reaching the level required. This way we were able to establish ' maximum dosage by his reactions and also we felt it gave the body and also time to adjust as he acted as though he was seeing the world through new eyes for the first time (the pre school teachers words not mine). Good luck all, hope you have as much luck as we did. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2001 Report Share Posted August 9, 2001 : What is P5P and how do you get it? What is it supposed to do for the system? Thanks. Joan Re: [ ] Re: TMG We have on both P5P and TMG. The two seem to work together very well for . He was non verbal until three days after stopping dairy products when he identified four numbers verbally in front of my 'very negative to the diet' mother who nearly died of shock!! Now of course she is completely converted having nearly had me locked away for insanity! We then put on P5P to start with and found his speech increased quite a lot. Once we added TMG with folic acid, about a month later, we saw such a change in him. It is certainly not just speech but EVERYTHING. His eye contact, his awareness to the world, his humour, his concentration etc etc. When we ran out of TMG the other week it was horrendous and we are under no doubt that the TMG works for him. We also made a daily log to record improvements. This has played an important part in his official diagnosis which he received last week. One tip I would give anyone starting on P5P or TMG is take it slowly. We only added 1 ml every few days until reaching the level required. This way we were able to establish ' maximum dosage by his reactions and also we felt it gave the body and also time to adjust as he acted as though he was seeing the world through new eyes for the first time (the pre school teachers words not mine). Good luck all, hope you have as much luck as we did. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2001 Report Share Posted August 9, 2001 Joan, It is large dose vitamins including B6 I think which is supposed to help communication. If you go to WWW.Kirkmanlabs.com they have a good site which will give you all of the details. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2001 Report Share Posted August 9, 2001 Apologies to Rhonda and Joan, Rhonda is quite right but you threw me. I hadn't realised that your heading was about TMG but the question you asked me was about P5P. These are two seperate things of course, either way if you want to clarify contents www.kirkmanlabs.com will have the details. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2001 Report Share Posted August 9, 2001 Hi Joan, TMG is NOT a mega vitamin with high concentrations of B6. TMG stands for Trimethylglycine, an amino acid. I believe the product is referring to is Super-Nu-Thera, also sold by Kirkmans, which is a high dose multi-vitamin. They do have some good articles on the use of TMG, but I wanted to clarify that TMG is not a multi-vitamin. It has seemed to help with expressive language and communication for my son. Rhonda > Joan, > > It is large dose vitamins including B6 I think which is supposed to help > communication. If you go to WWW.Kirkmanlabs.com they have a good site which > will give you all of the details. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2003 Report Share Posted April 22, 2003 Sorry - my mistake - he's been on *4* caps/day for a very long time, not 2. Thanks, Michele Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2003 Report Share Posted April 22, 2003 My daughter took TMG with good results (1/4 tsp 2-3 times a day) before she started Houston enzymes. Then on enzymes she started getting a rash that I was advised was from too much vit B absorption so we cut back on the TMG until we wound up eliminating it without any regression. A couple of months ago I decided to reintroduce it at a very small dose (1/8 tsp max) a couple times a day and had excellent results. We saw mood improvement, better attention span and she has seemed to get fewer colds so I think it boosted her immune system. I have not tried/don't plan to increase the dose. --- In , hugsfam5@c... wrote: > My son has been on 2 caps of TMG for a very long time with no verbal benefits > noted (I was told it was to help him verbally if at all). I'm taking him off > it for a few days to see if there is any other reason to continue. It's been > recommended for me to keep increasing the dosage as some children get very > high dosages of TMG before seeing benefits. I'm not sure if I should try that > or not. Anyone with TMG experiences they can share? > > Thanks in advance, > Michele Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2003 Report Share Posted April 24, 2003 TMG and B12 are both part of what is called " one carbon metabolism " . A folic acid derivative (5-methyl-tetrahydrofolate) donates a methyl group (which is 3 hydrogens bonded to a carbon) to homocysteine to form methionine. Methionine is part of a number of pathways involved in DNA repair and synthesis, methylation of phospholipids and membrane fluidity, neurotransmitter function, etc. Usually, vitamin B12 is utilized to transfer the methyl group from folate to homcysteine to form methionine. An alternative but less common pathway is the utilization of TMG as the methyl donor to homocysteine to form methionine. Another word for TMG is betaine. Thus, if the B12 cycle is abnormal for some reason, supplementation with TMG can compensate. Homocysteine is also converted via several reactions to glutathione. Vitamin B6 and magnesium are needed for one of the steps in this pathway. Valentina Scharpf wrote: >>Then on enzymes she started >>getting a rash that I was advised was from too much vit B absorption >>so we cut back on the TMG until we wound up eliminating it without >>any regression. >> >> > >Am I missing something here? >What's the connection between TMG and the B vitamins? >I mean are you saying that TMG is a B vitamin? >Can you please explain? I don't understand... > > >Valentina > > > >======================================================= > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2003 Report Share Posted April 24, 2003 Sorry...the TMG also has folic acid and vit B in it. This is a Kirkman mix. We had already eliminated the Super Nu Thera and thought that would get rid of enough B, but apparently even the lesser amount in the TMG caused a reaction. It is apparently because the enzymes cause a higher level of absorbtion. --- In , Valentina Scharpf <val@t...> wrote: > > Then on enzymes she started > > getting a rash that I was advised was from too much vit B absorption > > so we cut back on the TMG until we wound up eliminating it without > > any regression. > > Am I missing something here? > What's the connection between TMG and the B vitamins? > I mean are you saying that TMG is a B vitamin? > Can you please explain? I don't understand... > > > Valentina Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2003 Report Share Posted April 24, 2003 Sallie, >Message: 25 > Date: Wed, 23 Apr 2003 18:12:46 -0600 > From: Sallie Bernard <sbernard@...> >Subject: Re: Re: TMG > >TMG and B12 are both part of what is called " one carbon metabolism " . A >folic acid derivative (5-methyl-tetrahydrofolate) donates a methyl group >(which is 3 hydrogens bonded to a carbon) to homocysteine to form >methionine. Methionine is part of a number of pathways involved in DNA >repair and synthesis, methylation of phospholipids and membrane >fluidity, neurotransmitter function, etc. Usually, vitamin B12 is >utilized to transfer the methyl group from folate to homcysteine to form >methionine. An alternative but less common pathway is the utilization of >TMG as the methyl donor to homocysteine to form methionine. Another word >for TMG is betaine. Thus, if the B12 cycle is abnormal for some reason, >supplementation with TMG can compensate. > > can or should? >Homocysteine is also converted via several reactions to glutathione. >Vitamin B6 and magnesium are needed for one of the steps in this pathway. > > > Thanks Thanks Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2003 Report Share Posted April 24, 2003 Betaine supplementation has been used for Down Syndrome, those with the Down mutation (MTHFR gene), heart disease, and other homocysteine-related diseases with success. It is being tested in Angelman syndrome and Rett syndrome, but I don't believe the results are in yet. These disorders result from abnormal methylation. The Autism Research Institute tracks success (by parental report) of various supplements for autism and I believe they say betaine helps in a good percent of cases but certainly not all. So probably the words " should " or " can " are both wrong and it should be " might " . I also forgot to add that thimerosal, at very low concentrations, is a potent inhibitor of the folate-homocysteine-methionine pathway. wrote: >Sallie, > > > >>Message: 25 >> Date: Wed, 23 Apr 2003 18:12:46 -0600 >> From: Sallie Bernard <sbernard@...> >>Subject: Re: Re: TMG >> >>TMG and B12 are both part of what is called " one carbon metabolism " . A >>folic acid derivative (5-methyl-tetrahydrofolate) donates a methyl group >>(which is 3 hydrogens bonded to a carbon) to homocysteine to form >>methionine. Methionine is part of a number of pathways involved in DNA >>repair and synthesis, methylation of phospholipids and membrane >>fluidity, neurotransmitter function, etc. Usually, vitamin B12 is >>utilized to transfer the methyl group from folate to homcysteine to form >>methionine. An alternative but less common pathway is the utilization of >>TMG as the methyl donor to homocysteine to form methionine. Another word >>for TMG is betaine. Thus, if the B12 cycle is abnormal for some reason, >>supplementation with TMG can compensate. >> >> >> >> >can or should? > > > >>Homocysteine is also converted via several reactions to glutathione. >>Vitamin B6 and magnesium are needed for one of the steps in this pathway. >> >> >> >> >> >Thanks > >Thanks > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2003 Report Share Posted April 24, 2003 > Sorry...the TMG also has folic acid and vit B in it. This is a > Kirkman mix. Ok, now I understand. Thanks for making that clear Valentina Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2003 Report Share Posted April 24, 2003 > >Thus, if the B12 cycle is abnormal for some reason, > >supplementation with TMG can compensate. > > > > > can or should? Can. But... The enzyme that uses TMG to turn homocysteine into methionine exists mostly in the liver and kidney. The other enzyme (methionine synthase) that uses B12 and folate for the same reaction is expressed in most tissues (less expressed in liver and kidneys), including brain and heart. So I guess even if TMG can compensate for the problem, I think you still have to do something to stimulate the other pathway too (methionine synthase). I think it's very important. Valentina Quote Link to comment Share on other sites More sharing options...
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