lactic acid

[Guest guest]

Hi,

As one with definate lactic acidosis, I'm learning what I can about it.

Apparently lactic acid builds up in muscles with exercise and activity, but

then burns off. If lactic acid builds up it acts as poison causing free

radical damage, pain, weakness (exercise intolerance) and brain dysfunction.

Sometimes lactic acid is seen in brain with an MRS, and it can be seen in

organic blood and urine testing.

I have lactic acidosis due to faulty acting mitochondria - mitos have holes

in them, was told at CC that lactic acidosis always indicates a problem with

mitochondria. The treatment, *not cure*, is large doses of CO-Q 10,

carnitine, alpha lipoic acid, selenium, Vit. C and E. These antioxidents

are used to lessen the free radical damage to tissues. The mito cocktail is

tailored to the person depending on what disorder one has, but the above are

standard.

Recommendations from the June International Mito Conference

for Mito Cocktail include the following:

Suggested to most of my patients:

CoQ10 5-15 mg. per kg/daily (formula = weight divided by 2.2

multiplied by 10)

levo-carnitine Variable, starting dose 330

mg/kg/day

(Carnitor) typical max. of 100 mg/kg (330mg 3x/day of

levocarnitine or carnitor

as it is called by script)

Riboflavin (B2) 100-400 mg/ day

Second Tier Supplements:

Acetyl-L-Carnitine 250-1000 mg/day

Thiamine (B1) 50-100 mg/day

Nicotinamide (B3) 50-100 mg./day

Vit. E 200-400 I U, 1-3 day

Vit. C 100-500 mg., 1-3 day

Lipoic Acid 60-200 mg, 3 a day

Selenium 25-50 mcg. day

beta-Carotene 10,000 I U every other day

to daily

Biotin 2.5 -10 mg. day

Folic Acid 1-10 mg day

Meds., Minerals, Vitamins, Substrates that may be

helpful

(Only to be used under physicians directions)

Calcium Variable

Magnesium Variable

Vitamin K3 5-30 mg./day

Succinate 6 gram/ day

Creatine 5 gm bid after initial load

Uridine To be determined

Citrates Variable

Prednisone Variable

There are clinical trials now on DCA (don't know long name), which is a drug

used in Canada to reduce lactic acid. One of the members on my mito list,

is involved with it now in SanDiago. But for now, the tx is large doses of

antioxidents to reduce damage.

If anyone has been told this could be a problem, please take it seriously as

it is genetic and can be *passed to children* - even if you are the first to

have a mutation - due to toxins, infection, or recessive inheritance. A big

concern is malignant hyperthermia during surgery as wrong anesthesia can

kill, and is most common in people with mito. Friend of mine's first sign

was the hyperthermia, but she is in almost total denial about effects on

her kids.

If anyone is interested there is more info at the United Mitochrondrical

Disease Foundation at http://www.umdf.org.

I was wondering how you used the epsom salts for lactic acid - in the bath?

Bi-carbs have also been used, but are not necessarily effective according to

scientific community now.

Hope this helps and take care,

Christie

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> From: " phoenix " <phoenixx@...>

>Judith,

>>I don't know if the post exertion pain and exhaustion is lactic acid. It

might be part of the story.

>

>When trying to explain my symptoms to others, I've often used the example

of a marathon runner - who can do the run, but might hit that " brick wall "

that I've heard them describe - where suddenly they cannot run anymore, or

how someone will feel the effects of a work-out the day after. So, I

thought it's possible that I may have a more extreme version of this.

Another thing is, that I've been deficient in vitamins and minerals for a

long time , so I'm probably deficient in amino acids too. There's one more

thing that makes me want to reduce lactic acid. I find epsom salt balts

very very helpful, I've read that they reduce lactic acid, if that's what

they're doing that helps give me relief, then maybe taking something orally

will help keep it under control. Even if it's not the whole picture, and

something will reduce my pain even a little - I'll take it!

>

>I really don't know anyhtining more, I'm just experimenting, and I thought

amino acids would be safe enough to do so with.

>>Take care,

>>Phoenix

>-------------------

>

>

> From: Judith F Wisdom

>> But do we know that this reaction is lactic acid?

>> I too am very interested in the lactic acid mechanism as a possible one

> for the terrible exhuastion and pain, but I can't say with confidence

> that it is. Do you know something I don't?

>

>