The complement system #4 & #5

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Immunopharmacology 2000 Aug;49(1-2):133-48

Complement inhibitors: a resurgent concept in anti-inflammatory

therapeutics.

Sahu1 A, Lambris JD

Protein Chemistry Laboratory, Department of Pathology and Laboratory

Medicine, University of Pennsylvania, 401 Stellar-Chance

Laboratories, 19104, Philadelphia, PA, USA.

[Medline record in process]

In addition to its essential role in immune defense, the complement

system contributes to tissue damage in many clinical conditions.

Thus, there is a pressing need to develop therapeutically effective

complement inhibitors to prevent these adverse effects. This concept,

though old, received little scientific attention until recently. Data

from animal models of diseases that have been produced using

complement-deficient, knockout, and transgenic animals, as well as

data demonstrating that complement proteins are produced in many

important tissue sites (including the brain) have attracted the

interest of many basic research scientists and applied scientists

from the biotechnology field and larger pharmaceutical firms. This

resurgence of interest has generated a wealth of new information in

the field of complement inhibition. In this article, we

comprehensively review up-to-date information in the field of

complement inhibitors.

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Licorice extract inhibits complement. 3 abstracts:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search & DB=PubMed