Re: Genetic Link Found. Interesting article!

[Guest guest]

benitez wrote:

Very interesting article regarding a genetic mutation

in CFIDS.

-------------

Hi Benitez,

I think this is the article you referenced. I thought

that this was interesting also particularly this

sentence as I invariably feel worst from about an hour

after breakfast up to midday: " Those who have the

gene mutation show a particular kind of chronic

fatigue that is worst in the morning. "

>>>1. Genetic link to CFS is explored

A possible genetic link to CFS has been presented in a

paper to the 11th International Congress of

endocrinology, held in Sydney, Australia on Oct. 30.

Dr. Torpy, an endocrinology researcher at the

University of Queensland has examined over 30 members

of a family in Australia who exhibit chronic fatigue,

and a number of whom have CFS. These patients showed

a particular gene mutation which was associated with

a lower than normal level of a protein called cortisol

binding globulin. In fact, Dr. Torpy has found that:

" People who inherit one copy of the mutated gene

produce only half the normal amount of protein, and

people with two copies do not produce any of this

protein at all, " according to an interview given to

the Australian Associated Press.

The protein enables the hormone cortisol to be

transported in the blood. Cortisol is produced by the

adrenal glands in response to stress, and it plays a

role in immune response. While these patients show

low levels of cortisol, they nonetheless show normal

levels of ACTH, therefore they do not have 's

disease. Those who have the gene mutation show a

particular kind of chronic fatigue that is worst in

the morning. It is not yet clear what proportion of

CFS patients have the gene mutation.

Variants of this gene mutation have also been found in

two other families that are subject to chronic

fatigue, one in Brazil and another in France.

A broader study is being made among some 300 CFS

patients in Queensland and . In addition, a

treatment trial is being planed that involves

glucocorticoid supplements. A paper on the initial

study is expected to be published by March or April of

next year.

[Thanks to Dr. Torpy for providing information

for this article. Much information was also drawn

from a newswire story by the Australian Associated Press.]

__________________________________________________

[Guest guest]

I am going to Australia to do some CFS research and testing. do you

have the contact for Dr Torphy form the article. No luck searching the UQ

website

Thanks

Ho

Email: justinho@...

Re: Genetic Link Found. Interesting article!

> benitez wrote:

>

> Very interesting article regarding a genetic mutation

> in CFIDS.

> -------------

>

> Hi Benitez,

>

> I think this is the article you referenced. I thought

> that this was interesting also particularly this

> sentence as I invariably feel worst from about an hour

> after breakfast up to midday: " Those who have the

> gene mutation show a particular kind of chronic

> fatigue that is worst in the morning. "

>

>

> >>>1. Genetic link to CFS is explored

>

> A possible genetic link to CFS has been presented in a

> paper to the 11th International Congress of

> endocrinology, held in Sydney, Australia on Oct. 30.

>

> Dr. Torpy, an endocrinology researcher at the

> University of Queensland has examined over 30 members

> of a family in Australia who exhibit chronic fatigue,

> and a number of whom have CFS. These patients showed

> a particular gene mutation which was associated with

> a lower than normal level of a protein called cortisol

> binding globulin. In fact, Dr. Torpy has found that:

> " People who inherit one copy of the mutated gene

> produce only half the normal amount of protein, and

> people with two copies do not produce any of this

> protein at all, " according to an interview given to

> the Australian Associated Press.

>

> The protein enables the hormone cortisol to be

> transported in the blood. Cortisol is produced by the

> adrenal glands in response to stress, and it plays a

> role in immune response. While these patients show

> low levels of cortisol, they nonetheless show normal

> levels of ACTH, therefore they do not have 's

> disease. Those who have the gene mutation show a

> particular kind of chronic fatigue that is worst in

> the morning. It is not yet clear what proportion of

> CFS patients have the gene mutation.

>

> Variants of this gene mutation have also been found in

> two other families that are subject to chronic

> fatigue, one in Brazil and another in France.

>

> A broader study is being made among some 300 CFS

> patients in Queensland and . In addition, a

> treatment trial is being planed that involves

> glucocorticoid supplements. A paper on the initial

> study is expected to be published by March or April of

> next year.

>

> [Thanks to Dr. Torpy for providing information

> for this article. Much information was also drawn

> from a newswire story by the Australian Associated Press.]

>

> __________________________________________________

>

[Guest guest]

Hi ,

Sry I have no contact information, article was from

CFS News archives.

J

-------------

I am going to Australia to do some CFS research and

testing. do

you

have the contact for Dr Torphy form the article.

__________________________________________________