Re: fibrinogen, hyper-coagulation and licorice?????

[Guest guest]

Hi Dave,

What protocol would you suggest for this

pharmacological action of GA, bearing in mind that

some may not wish to increase cortisol bioactivity due

to concerns over possible side effects from chronic

regular usage. Would it work if taking the LE with

food (which would reduce the cortisol enhancing

effects as the GA would not be being effectively

hydrolysed into its active form to inhibit 18 beta

HSD, the enzyme that breaks down cortisol).

Essentially, is it possible to maximise the thrombin

inhibition whilst minimising inhibition of 18 beta

HSD? What dose and frequency would you suggest, how

about 100mg GA (eg, 1g Baschetti extract) per day with

breakfast, or well before breakfast if you intend to

boost cortisol aswell?

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Dave wrote:

If licorice is inhibiting thrombin and thrombin is

contributing to hyper-coagulation, then

hyper-coagulation might be related to CFS.

__________________________________________________

[Guest guest]

on <jamesinspace@y...> wrote:

> What protocol would you suggest for this

> pharmacological action of GA, bearing in mind that

> some may not wish to increase cortisol bioactivity due

> to concerns over possible side effects from chronic

> regular usage.

I'm not so sure that chronic use of licorice will increase cortisol

bioactivity. Dr. Posnecker gets good results by keeping his patients

on Baschetti every day for months. Baschetti inhibits 11 beta

hydroxysteriod dehydrogenase, the enzyme that deactivates cortisol.

But 11 beta hydroxysteriod dehydrogenase also has a feedback

mechanism. The more you inhibit this enzyme, the more enzyme the

body makes. You are not increasing cortisol bioactivity by any great

amount after 3-4 weeks on licorice extract simply because your body

is cranking up 11 berta hydroxysteroid dehydrogenase to the point

that the GA is no longer boosting cortisol much. This is why I

always recommended going off baschetti for a few days every week, or

taking it on an every other day schedule. Posnecker never did this

and his protocol got much better results over the long run than mine,

which is why I started looking around for other ways PWCs might be

benefiting from baschetti.

> Would it work if taking the LE with

> food (which would reduce the cortisol enhancing

> effects as the GA would not be being effectively

> hydrolysed into its active form to inhibit 18 beta

> HSD, the enzyme that breaks down cortisol).

Don't think so. Cutting down on amount of GA converted to 18-beta GA

by adding food will likely produce less thrombin inhibition. 18-beta

GA is the ingredient that is active against thrombin.

> Essentially, is it possible to maximise the thrombin

> inhibition whilst minimising inhibition of 18 beta

> HSD? What dose and frequency would you suggest, how

> about 100mg GA (eg, 1g Baschetti extract) per day with

> breakfast, or well before breakfast if you intend to

> boost cortisol aswell?

Dave