Re: complement

[Guest guest]

Hi, Dave,

Thanks for the info on complement and potential therapeutic complement

inhibitors.

Just wanted to comment that complement activation requires a surface of some

kind, with an antigen-bound antibody. Without the surface, there isn't any

way to keep the various factors together long enough to get activation. So

peptides (like from leaky gut) are unlikely to give activation.

Also, complement is IgG-specific. IgE, the classical allerigy antibody type,

doesn't work.

Jerry

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[Guest guest]

" Jerry " <jerrycam@h...> wrote:

>>>>>> .....Just wanted to comment that complement activation

requires a surface of some kind, with an antigen-bound antibody.

Without the surface, there isn't any way to keep the various factors

together long enough to get activation. So peptides (like from leaky

gut) are unlikely to give activation. Also, complement is IgG-

specific. IgE, the classical allerigy antibody type, doesn't

work.<<<<<

Jerry, from what I've read, increased permeability of the gut

stimulates the classic hypersensitivity responses to foods and

components on the normal gut flora; bacterial endoxtoxins, cell wall

polymers and dietary gluten may cause " non-specific " activation of

inflammatory pathways mediated by complement and by cytokines.

I'm not sure current medical researcher are fully aware of all that

is going on...most of the stuff is not yet 2 years old.

The way I understand, one can become allergic to pieces of bacteria

(endotoxin) that get into the blood stream via a leaky gut, which

stimulates the complement system. Why can't one become allergic to

fillers and chemcials in the same fashion, especially in the kidneys?

Dave