Piracetam useful against cancer

[Guest guest]

This was posted to MCSFN, here on egroups. I thought that this might

be interesting, since some of us are using pirecetam, and I know of

at least on PWC who is coping with cancer as well... (I know it's

potentially going off into off-topic territory...but...)

Laurie Lassesen

Carcinogenesis and the central nervous system.

Author von Metzler A; Nitsch C Address Source Cancer Detect

Prev, 1986, 9:3-4, 259-77 Abstract Wistar rats were injected with

the carcinogen 3-MC. The effect of psychoactive drugs on tumor-

bearing rats was examined with respect to tumor growth, survival

time, and remissions. CNS drugs were given both prophylactically and

therapeutically. Psychopharmaceuticals like piracetam and pyrithioxin

as well as catecholamine-agonists like imipramine had a definite

antineoplastic effect. This effect was increased when combined with

other CNS drugs and, in particular, the combination of piracetam with

chemotherapeutic agents resulted in a high rate of remission and

reduced the toxicity of chemotherapy. Surgical removal of tumors and

subsequent treatment with CNS drugs led to a high rate of cure

without metastasis. After tumor appearance, we found cerebral

neuropathological changes as described in the paraneoplastic

syndrome. The EEGs of 3-MC-injected rats showed early pathognomic

changes in frequency and amplitude. Similar changes were found in

animals with transplantation tumors ( carcinoma and Jensen

sarcoma). The EEG pattern was normalized after surgical removal of

Jensen sarcoma and treatment with piracetam and pyrithioxin. These

EEG changes might have occurred as a result of transmitter

metabolism; ie, carcinogenesis of both induced tumors and

transplanted tumors was accompanied by an increase of GABA content in

hypothalamus and hippocampus and a reduced concentration of

monoamines or their metabolites in hypothalamus and caudate nucleus.

Long-term treatment with piracetam or imipramine again arrested all

these changes. More recently, we achieved good results with the

combination of CNS drugs and cAMP agonists. We therefore conclude

that carcinogenesis interferes with the metabolism or availability of

cyclic nucleotides and transmitters that regulate their level. CNS

drugs may effect a new balance resulting in tumor suppression.

[Guest guest]

Wow, great news, thanks Laurie for posting it

Stania

-----Pùvodní zpráva-----

Od: Laurie L. <laurie@...>

Komu: egroups <egroups>

Datum: 23. srpna 2000 23:31

Pøedmìt: Piracetam useful against cancer

>This was posted to MCSFN, here on egroups. I thought that this might

>be interesting, since some of us are using pirecetam, and I know of

>at least on PWC who is coping with cancer as well... (I know it's

>potentially going off into off-topic territory...but...)

>Laurie Lassesen

>

>

>Carcinogenesis and the central nervous system.

>Author von Metzler A; Nitsch C Address Source Cancer Detect

>Prev, 1986, 9:3-4, 259-77 Abstract Wistar rats were injected with

>the carcinogen 3-MC. The effect of psychoactive drugs on tumor-

>bearing rats was examined with respect to tumor growth, survival

>time, and remissions. CNS drugs were given both prophylactically and

>therapeutically. Psychopharmaceuticals like piracetam and pyrithioxin

>as well as catecholamine-agonists like imipramine had a definite

>antineoplastic effect. This effect was increased when combined with

>other CNS drugs and, in particular, the combination of piracetam with

>chemotherapeutic agents resulted in a high rate of remission and

>reduced the toxicity of chemotherapy. Surgical removal of tumors and

>subsequent treatment with CNS drugs led to a high rate of cure

>without metastasis. After tumor appearance, we found cerebral

>neuropathological changes as described in the paraneoplastic

>syndrome. The EEGs of 3-MC-injected rats showed early pathognomic

>changes in frequency and amplitude. Similar changes were found in

>animals with transplantation tumors ( carcinoma and Jensen

>sarcoma). The EEG pattern was normalized after surgical removal of

>Jensen sarcoma and treatment with piracetam and pyrithioxin. These

>EEG changes might have occurred as a result of transmitter

>metabolism; ie, carcinogenesis of both induced tumors and

>transplanted tumors was accompanied by an increase of GABA content in

>hypothalamus and hippocampus and a reduced concentration of

>monoamines or their metabolites in hypothalamus and caudate nucleus.

>Long-term treatment with piracetam or imipramine again arrested all

>these changes. More recently, we achieved good results with the

>combination of CNS drugs and cAMP agonists. We therefore conclude

>that carcinogenesis interferes with the metabolism or availability of

>cyclic nucleotides and transmitters that regulate their level. CNS

>drugs may effect a new balance resulting in tumor suppression.

>

>

>

>

>This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

>