Re: HLA-DQ

[Guest guest]

Donna--what is DQ2-- from Boston

________________________________

From: Donna <donna9513@...>

achalasia

Sent: Wed, December 1, 2010 11:16:31 AM

Subject: HLA-DQ

 

Notan, What other problems are we talking about in regards to DQ2? I can take

it! I'm almost 62 yrs. old acquired MdDS 11 yrs. ago, dysphagia now Achalasia 2

yrs. ago. I have become one tough old broad.

LOL! Gotta find some humor where possible!

Donna Hall

Notan wrote:

> HLA-DQ Antigens present: DQ2

Of interest in achalasia seems to be HLA-DQ1 but not HLA-DQ2. DQ2 is

associated with enough other problems so people with it probably don't

want achalasia added to the list.

[Guest guest]

, I know exactly how to describe an HLA-DR, DQ phenotype test, I know it

is important in matching organ donors and identifying antigens. I did find that

DQ2 has a high association with autoimmune. I haven't been diagnosed with

Coeliac disease, but nor have I been tested.

Perhaps Notan can add his wisdom. Donna Hall

http://en.wikipedia.org/wiki/Human_leukocyte_antigen

DQ2 has the highest association of any HLA serotype with autoimmune disease,

close to 95% of all coeliacs have DQ2, of that 30% have 2 copies of DQ2. Of the

DQ2 homozygotes who eat wheat, life long risk is between 20 and 40% for coeliac

disease.

> > HLA-DQ Antigens present: DQ2

>

> Of interest in achalasia seems to be HLA-DQ1 but not HLA-DQ2. DQ2 is

> associated with enough other problems so people with it probably don't

> want achalasia added to the list.

>

>

>

>

>

>

>

>

[Guest guest]

Donna wrote:

> What other problems are we talking about in regards to DQ2?

Idiopathic sporadic ataxia, celiac (coeliac) disease, gluten ataxia,

type 1 diabetes, Stiff-Person syndrome (SPS), autoimmune thyroid

disease, multiple sclerosis, narcolepsy and autoimmune polyendocrine

syndromes. I am sure there are others too.

For those that are wondering, HLA-DQ2 refers to genes that are part of

the genetics involved in providing a way for the immune system to

determine cells of the body, self, from non-self cells and antigens.

HLA-DQ1, another reference to these types of genes, is believed to carry

some increased risk for achalasia. On a positive note, DQ1 has also been

link to longevity in one study.

notan

[Guest guest]

Thanks Notan,

I have hypothyroidism, however my Dr. just lowered my dosage, but I have to be

rechecked in 5 weeks.

As for any type of ataxia, the other rare condition I have Mal de Debarquement

causes balance problems. The exact cause of this is unknown at this time, other

then it is a neurological disorder, somewhat like an internal Parkinsons with no

outward and observable movements. The sensations (rocking) runs all the way

from the top of my head, down my spine/legs/feet. Sometimes I feel that the

esophageal spasms I have is directly a result or at least offspring of this

other disorder. No way to verify it of course.

Donna Hall

> > What other problems are we talking about in regards to DQ2?

>

> Idiopathic sporadic ataxia, celiac (coeliac) disease, gluten ataxia,

> type 1 diabetes, Stiff-Person syndrome (SPS), autoimmune thyroid

> disease, multiple sclerosis, narcolepsy and autoimmune polyendocrine

> syndromes. I am sure there are others too.

>

> For those that are wondering, HLA-DQ2 refers to genes that are part of

> the genetics involved in providing a way for the immune system to

> determine cells of the body, self, from non-self cells and antigens.

> HLA-DQ1, another reference to these types of genes, is believed to carry

> some increased risk for achalasia. On a positive note, DQ1 has also been

> link to longevity in one study.

>

> notan

>