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Genetically Engineered Cells May Stimulate Natural

Defense Against Epstein-Barr Virus (EBV)

A study published in the most recent issue of the

Journal of Virology describes a novel process that

researchers say may help in the development of a

vaccine for treatment and prevention of Epstein-Barr

virus (EBV). EBV has been associated with a number of

malignant conditions, especially in people with compromised

immune systems.

Scientist took dendritic (nerve) cells, which direct the

immune response at a cellular level, and genetically

modified them to react against EBV. This EBV-immune

response information is then stored until needed using

altered adenoviruses. These viruses that cause respiratory

or eye infections are used in genetic therapy to carry

specific anti-tumor genes.

Scientists reported that this method was successful in

stimulating EBV-specific immune-response cells in test

tubes; further testing will decide the potential of this

genetic technology for EBV-associated malignancies.

12-19-99

Source: Dendritic cells transduced with an adenovirus

vector encoding Epstein-Barr virus latent membrane

protein 2B: a new modality for vaccination. Journal of Virology

1999;73(12):10416-10425.

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