Re: New article in JAMA .... on

[Guest guest]

Huh?

slow girl in OH (dawn)

>

> http://ajpgi.physiology.org/cgi/content/abstract/288/5/G927?ct

>

>

> NEUROREGULATION AND MOTILITY Crural diaphragm inhibition during

esophageal distension correlates with contraction of the esophageal

longitudinal muscle in cats Jianmin Liu, L. Puckett, Torahiko

Takeda, Hwoon-Yong Jung, and Ravinder K. Mittal

> Department of Gastroenterology, University of California San Diego

and San Diego Veterans Affairs Medical Center, San Diego, California

> Submitted 6 August 2004 ; accepted in final form 16 December 2004

>

> Esophageal distension causes simultaneous relaxation of the lower

esophageal sphincter (LES) and crural diaphragm. The mechanism of

crural diaphragm relaxation during esophageal distension is not well

understood. We studied the motion of crural and costal diaphragm

along with the motion of the distal esophagus during esophageal

distension-induced relaxation of the LES and crural diaphragm. Wire

electrodes were surgically implanted into the crural and costal

diaphragm in five cats. In two additional cats, radiopaque markers

were also sutured into the outer wall of the distal esophagus to

monitor esophageal shortening. Under light anesthesia, animals were

placed on an X-ray fluoroscope to monitor the motion of the diaphragm

and the distal esophagus by tracking the radiopaque markers. Crural

and costal diaphragm electromyograms (EMGs) were recorded along with

the esophageal, LES, and gastric pressures. A 2-cm balloon placed 5

cm above the LES was used for esophageal distension. Effects

> of baclofen, a GABAB agonist, were also studied. Esophageal

distension induced LES relaxation and selective inhibition of the

crural diaphragm EMG. The crural diaphragm moved in a craniocaudal

direction with expiration and inspiration, respectively. Esophageal

distension-induced inhibition of the crural EMG was associated with

sustained cranial motion of the crural diaphragm and esophagus.

Baclofen blocked distension-induced LES relaxation and crural

diaphragm EMG inhibition along with the cranial motion of the crural

diaphragm and the distal esophagus. There is a close temporal

correlation between esophageal distension-mediated LES relaxation and

crural diaphragm inhibition with the sustained cranial motion of the

crural diaphragm. Stretch caused by the longitudinal muscle

contraction of the esophagus during distension of the esophagus may

be important in causing LES relaxation and crural diaphragm

inhibition.

>

> lower esophageal sphincter relaxation

>

> ---------------------------------

>

> Address for reprint requests and other correspondence: R. K.

Mittal, Univ. of California San Diego, 3350 La Jolla Village Dr., La

Jolla, CA 92161 (E-mail: rmittal@u... " + u + " @ " + d + " " //--> )

>

>

>

>

>

>

>

>

> Wooleeacre Productions

> Custom Screenprinting

> on a small scale!

>

>

>

>

>

>

>

> ---------------------------------

> Mobile

> Take with you! Check email on your mobile phone.

>

>