Re: general unhappy ranting: Domperidone

[Guest guest]

Debbie writes:

Hey, I live just down the street from a Pfizer (used to be Pharmacia, used to be Pharmacia & Upjohn, and originally was just plain old Upjohn) manufacturing facility.... maybe the fumes from that are what's making my kid into such a little rascal! LOL

Deb

Girl, hush your mouth...the stock will go down if

that gets out. Besides I am inclined to believe

it is more the genes. LOL.

[Guest guest]

Jan,

I know people who work for the FDA, they are human like us and wants us to have what is best for us. I agree with Debbi about knowing the side effects. The FDA refuses approval of drugs in the US for usually two reasons: Safety and Efficacy.

Efficacy means how well does it work. This is only part of the study. The primary concern of the FDA is to preserve and protect the health of the American people. Just because a drug is effective does not mean that it is safe to use. As a Pharmaceutical Scientist, I have worked on many compounds that are remarkably powerful and are very dangerous to be exposed to. I have experimented with active ingredients that cause infertility, impotence, birth defects, spontaneous abortion, cancer, and even death.

Many drugs work very well such as Thalidomide, Thalidomide is a drug that was introduced on to the European and Canadian market in 1957. Thalidomide soon became a drug prescribed to pregnant women to combat symptoms associated with morning sickness. When taken during the first trimester of pregnancy, Thalidomide prevented the proper growth of the fetus resulting in horrific birth defects in thousands of children around the world. These children were born in the late 1950's and early 1960's and became known as "Thalidomide babies". Canada has a support group for its victims of Thalidomide.The problem never happened in the US. The FDA of the US requested additional studies on the effect of this drug on expecting mothers be done before it could be approved in the US. The drug was found to be unsafe before the drug company completed the study. If the FDA refuses to approve this drug then there are probably very good reasons for it.

Boston Pete

-----Original Message-----From: Debbi Heiser [mailto:heiser@...]Sent: Tuesday, March 09, 2004 9:25 AMachalasia Subject: Re: general unhappy ranting

Jan wrote:

Hey guys,I felt so embarassed to rant and rave like I did, you guys are so nice to put up with my complaints!

Seriously, Jan, don't give it a second thought. I did a "poor pathetic me" rant about a month or so ago (after my son witnessed a major spewing episode), and even though I've got it much better than many people, nobody cared that I was ranting. Most of us have BTDT (been there done that) and we know what it feels like physically and emotionally. Ranting lets you vent it out, and venting it out can be very freeing. You're among friends here.

Well, the GI doc today recommended I go to www.donperidone.com to get that medication over the Internet to help with my"unspecific motility disorder". (thats how he described my problem)

Jan, there is a list of places (including some in the US) to get Domperidone here: http://www.breastfeedingonline.com/domperidonewhere.shtml

One of the side effects of the drug is that it increases breastmilk production in lactating women.

The thing that concerns me, though, is what I read on this info sheet: http://www.inhousedrugstore.com/digestive/motilium-information-physicians.html

Studies in humans have shown intravenous and oral domperidone to increase the duration of antral and duodenal contractions, to increase the gastric emptying of liquids and semi-solids in healthy subjects and in patients in whom it was delayed, and to increase lower oesophageal sphincter pressure in healthy subjects.

It seems to me that if your doc suspects that you could possibly have the early signs of achalasia, a drug that INCREASES LES pressure is NOT gonna be a good idea. Also, there is a connection between the drug and breast tumors. If there is a history of breast cancer in your family, I would discuss it fully with both a doctor AND a pharmacist before I took a drug like this. B/c it's not FDA approved, your doc may not be fully aware of the potential side effects, so I would want to verify that he knows about both the pros and cons before taking the drug.

I hope you're feeling better, and please DO feel free to vent anytime. We're here to support each other!Deb

[Guest guest]

BostonPete wrote:

As a Pharmaceutical Scientist, I have worked on many compounds that are remarkably powerful and are very dangerous to be exposed to. I have experimented with active ingredients ......

Hey, now we know where Pete gets his great sense of humor!!! :oP Hey, I live just down the street from a Pfizer (used to be Pharmacia, used to be Pharmacia & Upjohn, and originally was just plain old Upjohn) manufacturing facility.... maybe the fumes from that are what's making my kid into such a little rascal! LOLDeb

[Guest guest]

Pete –

How strange that you brought up Thalidomide….this

is a drug that I had never heard of until this past weekend when my

father-in-law was visiting from Las

Vegas. He has scleroderma

and for the past 4 months has been prescribed Thalidomide, he told me about the

history of birth defects, and in fact before the prescription will be renewed

each month, he has to answer a survey and swear that he wont even be sexually

active without a condom. How scary….and I am 6 months pregnant so I was

making sure not to even touch his pill bottle!!

Off topic, but just struck me so strange

that Thalidomide came up again, we’ve been doing searches on line to

learn a little more about it over the last few days.

All the best,

Re: general

unhappy ranting

Jan wrote:

Hey guys,I felt so embarassed to rant and rave like I did,

you guys are so nice to put up with my complaints!

Seriously, Jan, don't

give it a second thought. I did a " poor pathetic me " rant about

a month or so ago (after my son witnessed a major spewing episode), and even

though I've got it much better than many people, nobody cared that I was

ranting. Most of us have BTDT (been there done that) and we know what it

feels like physically and emotionally. Ranting lets you vent it out, and

venting it out can be very freeing. You're among friends here.

Well, the GI doc today recommended I go to www.donperidone.com to get that

medication over the Internet to help with my " unspecific motility

disorder " . (thats how he described my problem)

Jan, there is a list

of places (including some in the US) to get Domperidone here: http://www.breastfeedingonline.com/domperidonewhere.shtml

One of the side

effects of the drug is that it increases breastmilk production in lactating

women.

The thing that

concerns me, though, is what I read on this info sheet: http://www.inhousedrugstore.com/digestive/motilium-information-physicians.html

Studies in humans have shown intravenous

and oral domperidone to increase the duration of antral and duodenal

contractions, to increase the gastric emptying of liquids and semi-solids in

healthy subjects and in patients in whom it was delayed, and to increase lower oesophageal

sphincter pressure in healthy subjects.

It seems to me that if

your doc suspects that you could possibly have the early signs of achalasia, a

drug that INCREASES LES pressure is NOT gonna be a good idea. Also, there

is a connection between the drug and breast tumors. If there is a history

of breast cancer in your family, I would discuss it fully with both a doctor

AND a pharmacist before I took a drug like this. B/c it's not FDA approved,

your doc may not be fully aware of the potential side effects, so I would want

to verify that he knows about both the pros and cons before taking the drug.

I hope you're feeling

better, and please DO feel free to vent anytime. We're here to support

each other!

Deb