Re: Olfactory ensheathing cells (OECs)

[Guest guest]

Well, Pete, you can bet if I get a chance to open my mouth in Cleveland, I'll be asking for a professional opinion on this very subject! Thanks!Debbi

Olfactory ensheathing cells (OECs)

There is much talk these days about using olfactory nerves to help regrow damaged nerve tissue in the spinal column. Some patients who are paraplegic have been give partial restoration of previously lost functions. The olfactory nervous system has an ability for regrowth that is uncharacteristic of other CNS areas.

In other words nasal nerves cells grow back when damaged, while other nerve cells don't. Nerve cells only pass signals from one point to another. So nose nerves can be used to replace spinal nerves. Paralyzed rats regained the ability to walk after OECs were implanted at the spinal cord break.

Does anyone think that the same principle could be used to try to restore lost LES function or Peristalsis?

http://www.ucs.mun.ca/~r82kmw/OEGessay.html

http://ntp.neuroscience.wisc.edu/neuro630/AddReading/Raisman2001.pdf

http://www.jneurosci.org/cgi/content/short/23/21/7783

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=10756071 & dopt=Abstract

http://www.blackwell-synergy.com/links/doi/10.1111/j.1469-7580.2004.00257.x/enhancedabs/

Boston Pete

[Guest guest]

Why not? Just where would they implant them though? At the ganglion in the spinal column or along a nerve channel somewhere ? What I haven't quite figured out is -are the nerves destroyed completely along the whole length of the nerve or only at the end section that leads to the E? Any one got any ideas?

JoanJohannesburg South Africajpearse@...

Olfactory ensheathing cells (OECs)

There is much talk these days about using olfactory nerves to help regrow damaged nerve tissue in the spinal column. Some patients who are paraplegic have been give partial restoration of previously lost functions. The olfactory nervous system has an ability for regrowth that is uncharacteristic of other CNS areas.

In other words nasal nerves cells grow back when damaged, while other nerve cells don't. Nerve cells only pass signals from one point to another. So nose nerves can be used to replace spinal nerves. Paralyzed rats regained the ability to walk after OECs were implanted at the spinal cord break.

Does anyone think that the same principle could be used to try to restore lost LES function or Peristalsis?

http://www.ucs.mun.ca/~r82kmw/OEGessay.html

http://ntp.neuroscience.wisc.edu/neuro630/AddReading/Raisman2001.pdf

http://www.jneurosci.org/cgi/content/short/23/21/7783

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=10756071 & dopt=Abstract

http://www.blackwell-synergy.com/links/doi/10.1111/j.1469-7580.2004.00257.x/enhancedabs/

Boston Pete

[Guest guest]

Thanks Pete,

Was that ever an interesting concept. I spent the last hour reading about migrating cells. I truly think it is feasable. I needed that hour to be able to stop laughing over Debbi thinking she could go to the conference and not open her mouth :-) Debbi, you'll never be able to do it! Honestly, I am looking forward to hearing about the conference. I wish I didn't live so far away. I sure hope you know I'm just teasing. Sometimes words don't come across the same way in an e-mail.

I really did laugh though,

.

[Guest guest]

Yes, , I knew you were teasing! LOL I know you well enough to know that it's pretty rare to find anything even CLOSE to being mean anywhere in you!!!

You'll be missed at the conference... it sure would be fun to get ALL of us together!Deb

Thanks Pete,

Was that ever an interesting concept. I spent the last hour reading about migrating cells. I truly think it is feasable. I needed that hour to be able to stop laughing over Debbi thinking she could go to the conference and not open her mouth :-) Debbi, you'll never be able to do it! Honestly, I am looking forward to hearing about the conference. I wish I didn't live so far away. I sure hope you know I'm just teasing. Sometimes words don't come across the same way in an e-mail.

I really did laugh though,

.

[Guest guest]

Joan,

This is something I know nothing about. Most of my interest has been put into understanding the anatomical problems associated with achalasia. I will look into the neurological sides of achalasia. If anyone can share some information on this I would appreciate it.

Pete

-----Original Message-----From: Joan Pearse [mailto:jpearse@...]Sent: Wednesday, April 14, 2004 2:06 PMachalasia Subject: Re: Olfactory ensheathing cells (OECs)

Why not? Just where would they implant them though? At the ganglion in the spinal column or along a nerve channel somewhere ? What I haven't quite figured out is -are the nerves destroyed completely along the whole length of the nerve or only at the end section that leads to the E? Any one got any ideas?

JoanJohannesburg South Africajpearse@...

Olfactory ensheathing cells (OECs)

There is much talk these days about using olfactory nerves to help regrow damaged nerve tissue in the spinal column. Some patients who are paraplegic have been give partial restoration of previously lost functions. The olfactory nervous system has an ability for regrowth that is uncharacteristic of other CNS areas.

In other words nasal nerves cells grow back when damaged, while other nerve cells don't. Nerve cells only pass signals from one point to another. So nose nerves can be used to replace spinal nerves. Paralyzed rats regained the ability to walk after OECs were implanted at the spinal cord break.

Does anyone think that the same principle could be used to try to restore lost LES function or Peristalsis?

http://www.ucs.mun.ca/~r82kmw/OEGessay.html

http://ntp.neuroscience.wisc.edu/neuro630/AddReading/Raisman2001.pdf

http://www.jneurosci.org/cgi/content/short/23/21/7783

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=10756071 & dopt=Abstract

http://www.blackwell-synergy.com/links/doi/10.1111/j.1469-7580.2004.00257.x/enhancedabs/

Boston Pete

[Guest guest]

I’ll be doing my best to keep her in

line , but I don’t know…I have a funny feeling that the two of

us might be trouble together! LOL

Seriously speaking, I hope Deb does get a chance to get a few words in! She’s a

wonderful representative for the group and I’m hoping that our presence

will be appreciated and that it will be an informative experience for all.

We’ll be sure to take good notes so

we can report back to everyone! I’m

bringing my voice recorder along so I don’t miss a thing.

Hopefully we’ll get a chance to visit

with in the hospital while we’re there, so if anyone would like to

share any well wishes for her, I’ll print them up and take them to her!

I’ll be leaving early tomorrow morning,

and Deb and I will be off to Cleveland tomorrow afternoon!

Sandi

Re: Olfactory

ensheathing cells (OECs)

Thanks

Pete,

Was that ever an interesting concept. I spent the last hour reading

about migrating cells. I truly think it is feasable. I needed that

hour to be able to stop laughing over Debbi thinking she could go to the

conference and not open her mouth :-) Debbi, you'll never be able

to do it! Honestly, I am looking forward to hearing about the

conference. I wish I didn't live so far away. I sure hope you know I'm

just teasing. Sometimes words don't come across the same way in an

e-mail.

I

really did laugh though,

.

[Guest guest]

wrote:

Does

anyone think that the same principle could be used to try to restore lost

LES function or Peristalsis?

I think it should be used to " try " to fix it. At a research

level anyway. The failure of the process to fix the cut retinal ganglion

cell axons in the rat sounds troubling to me. This, I think, is more like

the problem with the E than spinal cord injury. But differences in the

rat may make it not work for the rat and yet work for us. So there is

hope. Also, they are learning about the chemistry that prevents nerves

from just growing new connections and making repairs. The research could

lead to other way fix the E. Thanks for providing those links. Very

interesting.

notan

[Guest guest]

Joan wrote:

are

the nerves destroyed completely along the whole length of the nerve or

only at the end section that leads to the E? Any one got any

ideas?

My impression is that there is mainly degeneration of the esophageal

myenteric plexus of Auerbach, particularly the loss of ganglion cells. I

have also read that in early achalasia there is a more selective loss of

inhibitory postganglionic neurons and less degeneration of other parts of

the plexus. I see the esophageal myenteric plexus as a network in the

esophagus with preganglionic nerve meeting post ganglinonic nerve at

junctions in the esophagus called ganglions. So, my impression is that it

starts with the

inhibitory postganglionic nerves, which have their cell bodies in the

ganglions. Later there is degeneration of other nerves in the plexus, but

I assume that the degeneration does not extend to parts of the

preganglionic nerves outside the plexus. I could be wrong, so if you find

otherwise, pleases let us know.

notan

[Guest guest]

My answer was not complete. You can also have

achalasia from degeneration of the vagal motor nuclei at the brainstem.

There does not seem to be much written about this form of

achalasia.

notan

Joan wrote:

are

the nerves destroyed completely along the whole length of the nerve or

only at the end section that leads to the E? Any one got any

ideas?

notan

wrote:

My impression is that there is mainly degeneration of the esophageal

myenteric plexus of Auerbach, particularly the loss of ganglion cells. I

have also read that in early achalasia there is a more selective loss of

inhibitory postganglionic neurons and less degeneration of other parts of

the plexus. I see the esophageal myenteric plexus as a network in the

esophagus with preganglionic nerve meeting post ganglinonic nerve at

junctions in the esophagus called ganglions. So, my impression is that it

starts with the

inhibitory postganglionic nerves, which have their cell bodies in the

ganglions. Later there is degeneration of other nerves in the plexus, but

I assume that the degeneration does not extend to parts of the

preganglionic nerves outside the plexus. I could be wrong, so if you find

otherwise, pleases let us know.