Vitamin Supplement Use During Breast Cancer Treatment & Survival

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BCO NEWS

Vitamin Supplement Use During Breast Cancer Treatment and Survival: A

Prospective Cohort Study

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_+_

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Author Affiliations

Authors' Affiliations:1Division of Epidemiology, Department of Medicine,

Vanderbilt University School of Medicine, Nashville, Tennessee, and

2Shanghai Center for Disease Control and Prevention and Shanghai Institute of

Preventive Medicine, Shanghai, PR China

Abstract

Background: Antioxidants may protect normal cells from the oxidative

damage that occurs during radiotherapy and certain chemotherapy regimens;

however, the same mechanism could protect tumor cells and potentially reduce

effectiveness of cancer treatments. We evaluated the association of vitamin

supplement use in the first 6 months after breast cancer diagnosis and during

cancer treatment with total mortality and recurrence.

Methods: We conducted a population-based prospective cohort study of 4,877

women aged 20 to 75 years diagnosed with invasive breast cancer in

Shanghai, China, between March 2002 and April 2006. Women were interviewed

approximately 6 months after diagnosis and followed up by in-person interviews

and record linkage with the vital statistics registry.

Results: During a mean follow-up of 4.1 years, 444 deaths and 532

recurrences occurred. Vitamin use shortly after breast cancer diagnosis was

associated with reduced mortality and recurrence risk, adjusted for multiple

lifestyle factors, sociodemographics, and known clinical prognostic factors.

Women who used antioxidants (vitamin E, vitamin C, multivitamins) had 18%

reduced mortality risk (HR = 0.82, 95% CI: 0.65-1.02) and 22% reduced

recurrence risk (HR = 0.78, 95% CI: 0.63-0.95). The inverse association was

found

regardless of whether vitamin use was concurrent or nonconcurrent with

chemotherapy, but was present only among patients who did not receive

radiotherapy.

Conclusions: Vitamin supplement use in the first 6 months after breast

cancer diagnosis may be associated with reduced risk of mortality and

recurrence.

Impact: Our results do not support the current recommendation that breast

cancer patients should avoid use of vitamin supplements. Cancer Epidemiol

Biomarkers Prev; 20(2); 262-71. ©2010 AACR. This article is featured in

Highlights of This Issue, _p. 217_

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Supplemental Tables

_http://cebp.aacrjournals.org/content/suppl/2010/12/21/1055-9965.EPI-10-1072

..DC1/EPI-10-1072R1_Shu_Supp_Tables.pdf_

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Footnotes

Note: Supplementary data for this article are available at Cancer

Epidemiology, Biomarkers and Prevention Online (http://cebp.aacrjournals.org/).

RESOURCES

Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of

Resveratrol, a Potential Cancer Chemopreventive Agent.

http://cebp.aacrjournals.org/content/16/6/1246.short?rss=1 & ssource=mfc

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