Aluminum decreases the glutathione regeneration

[Guest guest]

Dr. Woleski,

Here's another published " scientific " article for you

to review on Aluminum. As a " doctor " you must be

aware that oxidative damage is associated with cancer

and many other diseases.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

5486972 & dopt=Abstract

Aluminum decreases the glutathione regeneration by the

inhibition of NADP-isocitrate dehydrogenase in

mitochondria.

Murakami K, Yoshino M.

Department of Biochemistry, Aichi Medical University

School of Medicine, Nagakute, Aichi 480-1195, Japan.

Effect of aluminum on the NADPH supply and glutathione

regeneration in mitochondria was analyzed. Reduced

glutathione acted as a principal scavenger of reactive

oxygen species in mitochondria. Aluminum inhibited the

regeneration of glutathione from the oxidized form,

and the effect was due to the inhibition of

NADP-isocitrate dehydrogenase the only enzyme

supplying NADPH in mitochondria. In cytosol, aluminum

inhibited the glutathione regeneration dependent on

NADPH supply by malic enzyme and NADP-isocitrate

dehydrogenase, but did not affect the glucose

6-phosphate dehydrogenase dependent glutathione

formation. Aluminum can cause oxidative damage on

cellular biological processes by inhibiting

glutathione regeneration through the inhibition of

NADPH supply in mitochondria, but only a little

inhibitory effect on the glutathione generation in cytosol

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