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If you copy the whole link you find this under: The whole link is till

abstract but in and e-mails sometimes part of the link doesn't work.

Gr. Kees Braam

J Mol Med. 2001;78(12):708-20. Related Articles, Links

Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.

Pavelic K, Hadzija M, Bedrica L, Pavelic J, Dikic I, Katic M, Kralj M,

Bosnar MH, Kapitanovic S, Poljak-Blazi M, Krizanac S, Stojkovic R, Jurin

M, Subotic B, Colic M.

Ruder Boskovic Institute, Division of Molecular Medicine, Zagreb, Croatia.

pavelic@...

Natural silicate materials, including zeolite clinoptilolite, have been

shown to exhibit diverse biological activities and have been used

successfully as a vaccine adjuvant and for the treatment of diarrhea. We

report a novel use of finely ground clinoptilolite as a potential adjuvant

in anticancer therapy. Clinoptilolite treatment of mice and dogs suffering

from a variety of tumor types led to improvement in the overall health

status, prolongation of life-span, and decrease in tumors size. Local

application of clinoptilolite to skin cancers of dogs effectively reduced

tumor formation and growth. In addition, toxicology studies on mice and

rats demonstrated that the treatment does not have negative effects. In

vitro tissue culture studies showed that finely ground clinoptilolite

inhibits protein kinase B (c-Akt), induces expression of p21WAF1/CIP1 and

p27KIP1 tumor suppressor proteins, and blocks cell growth in several

cancer cell lines. These data indicate that clinoptilolite treatment might

affect cancer growth by attenuating survival signals and inducing tumor

suppressor genes in treated cells.

Publication Types:

Clinical Trial

PMID: 11434724 [PubMed - indexed for MEDLINE]

>

> Why do you give sites that don't open?

> It is very annoying.

>

>

> -- Check out Entrez PubMed

>

> Click here: Entrez PubMed

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=npg & cmd=Retrieve &

> db=PubMed & list_uids=11434724 & dopt=Abstract

>

>

>

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