Leukemia + Beta Glucan

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Hi,

here is some general information on beta glucan and leukemia.

Beta Glucan can be extracted in a laboratory from several sources - usually

certain mushrooms or bakers

yeast.

The survival Rate of mice challenged with leukemia increased as the dosage

of beta glucan increased. 'Protective Effect of Glucan Against Systemic

Stapyloccocus aureau Septicemia in Normal and Leukemic Mice', Diluzio and

, Infection and Immunity, June 1978.*

Chronic administration of glucan to aging mice with

lymphocytic leukemia significantly improved their survival (DiLuzio, 1980).

SOURCE - Microbiologica 1983 Jul; 6(3):207-20

AU - Cassone A - Scaringi L - Pesce CD - Titti F - Bistoni F - Marconi P

TI - Suppression of Friend leukemia cell-induced tumours by

cellular preparations of Candida albicans.

ABSTRACT - Inactivated cellular preparations and cell wall materials of Candida

albicans

(CA) were tested for their capacity to suppress the growth of Friend Leukemia

Cell (FLC)-

induced tumours and the infection by Friend Leukemia Virus (FLV) in

histocompatible mice.

In particular, mice given 10(7) yeast cells, inactivated by cold alkali, on

days -14 and

+1 with respect to 10(4) FLC challenge on day 0 did not develop tumors.

Therefore, the

observed antitumor activity by CA was not mediated by antiviral effects but

possibly due

to an " adjuvant-type " , nonspecific, immunopotentiation of host antitumor

response, as

documented in other animal tumor models.

MH - Candida albicans|*IM

MH - Leukemia, Experimental|*TH

UI - 84038960

----------------------------------------------------------

Sakagami H Kawazoe Y

NOVEL ELUCIDATION OF THE MECHANISM OF INDUCTION OF VARIOUS

IMMUNOPOTENTIATING ACTIVITIES BY A PROTEIN-BOUND POLYSACCHARIDE, PSK

(MEETING ABSTRACT)

In: Anticancer Res (1990) 10(5B):1472

A protein-bound polysaccharide, PSK, extracted from the mycelium of

Coriolus versicolor (Fr) Quel, has been recognized for its host-

mediated antitumor and antimicrobial activity in mice. PSK and F4

stimulated the differentiation of human myelogenous leukemia cell

lines toward monocyte/macrophages, induced by various cytokines such

as tumor necrosis factor (TNF) and interferon-r (IFN-r). Binding

studies with 125I-TNF or 125I-IFN-r suggest that the stimulating

effect of the active PSK subfractions might be associated with

inhibition of the downregulation of receptor binding of these

cytokines. The data suggest that (1) immunopotentiation activity

of PSK might be ascribed, at least in part, to the stimulation or

production of various cytokines, and (2) PSK might have some unique

component(s) which directly stimulate the macrophage/PMN function.

Tokyo Japan

UI 92675773

-----------------------------------------------

PSK is an extract from the mushrom coliolus versicolor.

1: Cancer Immunol Immunother 1991;34(2):133-7

Potentiation of T cell immunity against radiation-leukemia-virus-induced

lymphoma by polysaccharide K.

Yefenof E, Einat E, Klein E

Lautenberg Centre for General and Tumour Immunology, Hebrew University Hadassah

Medical School, Jerusalem, Israel.

C57BL mice inoculated with radiation leukemia virus (RadLV) develop preleukemic

cells long before the onset of leukemia. These cells are potentially immunogenic

but fail to elicit an immune response in the host because of the appearance of

virus-specific suppressor T cells. We have studied the effect of polysaccharide

K (PSK) on the generation of RadLV-specific cell-mediated immune responses in

vitro. Long-term exposure to PSK in culture potentiated the ability of immunized

T cells to respond to a RadLV-induced lymphoma. It also abrogated the

suppressive activity of suppressor T cells and simultaneously boosted the

ability of reactive T cells to respond. The dual immunostimulating activity of

PSK resulted in the generation of T cytotoxic lymphocytes that could lyse

lymphoma cells in vitro. The results suggest that PSK could be used as a

prophylactic immune response modifier in preleukemia.

PMID: 1760817, UI: 92103646

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