Guest guest Posted December 24, 2003 Report Share Posted December 24, 2003 The worm research wasn't flawed, but like all research it is incomplete. There is no Grand Unified Experiment which will address all questions and quash every quibble. The roundworm is useful for studying longevity as its genes are very similar to mammalian (murine) in the regulation of CoQ7 which is involved in biological rhythms and life span. It is most active in heart, muscle, liver, and kidney. The roundworm genes that have been identified as conferring increased longevity do so by granting resistance to external stresses, such as high temperatures, radiation and oxidative damage. Ubiquinone (coenzyme Q) possesses a lipophilic side chain of isoprene subunits of varying length. Different biological processes have varying sensitivities to the chain length. This is being studied in many countries as no one has the answers yet. CoQ10 has been available for popular use for a couple of decades and has shown itself to be safe and useful for a number of chronic ailments. I have seen no miracles with cancer from its use. As the head of the molecule can be either an electron donor or acceptor we can assume that it may take some tweaking with dosages, synergists, and isoprene chain lengths to reveal its most productive anticancer use. The prooxidant properties of ubiqinone may be exactly what is needed for fighting cancer -- with a trade off that it may accelerate DNA degradation of paranchymal tissues of necessary organs. This is nothing new in the world of anticancer agents. I would not advise healthy people to use large doses of ubiquinone without first soberly reflecting on The Law of Unintended Consequences. another flawed study..... > It is very hard to compare worms to people... it is a long shot at best! > > You can Double the Lifespan of rats by feeding them every other day. > So what does that mean? > I would rather be dead than eat every other day. > > also you can take " antioxidants " to combat the " pro-oxidant " effects of > coenzyme Q 10. > > did they try that in the study???? I think not! > > > VGammill wrote: > > > > Researchers More than Double Worms Lifespan > > > > Researchers have more than doubled the lifespan of worms by simply depriving > > them of a micronutrient called coenzyme Q. Drs. Pamela L Larsen and > > F e found that adult worms fed on a coenzyme Q diet lived 59% > > longer than those fed a normal diet. Coenzyme Q is an antioxidant that helps > > to transport electrons during cellular respiration, however Larsen and > > e say that their results suggest that the substance may also have a > > " pro-oxidant " effect. If this is true, reducing the animals' consumption of > > coenzyme Q may extend lifespan by lowering oxidative damage to cells. > > However, the researchers say that it is not possible to lengthen the > > animals' lifespan simply by feeding them a coenzyme Q-free diet from birth, > > as worms fed such a diet were found to be significantly more likely to > > develop reproductive defects. > > > > SOURCE/REFERENCE: Science 2001; 295:120-123 > > > > Get HUGE info at http://www.cures for cancer.ws, and post your own links there. Unsubscribe by sending email to cures for cancer-unsubscribeegroups or by visiting htt > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 24, 2003 Report Share Posted December 24, 2003 The worm research wasn't flawed, but like all research it is incomplete. There is no Grand Unified Experiment which will address all questions and quash every quibble. The roundworm is useful for studying longevity as its genes are very similar to mammalian (murine) in the regulation of CoQ7 which is involved in biological rhythms and life span. It is most active in heart, muscle, liver, and kidney. The roundworm genes that have been identified as conferring increased longevity do so by granting resistance to external stresses, such as high temperatures, radiation and oxidative damage. Ubiquinone (coenzyme Q) possesses a lipophilic side chain of isoprene subunits of varying length. Different biological processes have varying sensitivities to the chain length. This is being studied in many countries as no one has the answers yet. CoQ10 has been available for popular use for a couple of decades and has shown itself to be safe and useful for a number of chronic ailments. I have seen no miracles with cancer from its use. As the head of the molecule can be either an electron donor or acceptor we can assume that it may take some tweaking with dosages, synergists, and isoprene chain lengths to reveal its most productive anticancer use. The prooxidant properties of ubiqinone may be exactly what is needed for fighting cancer -- with a trade off that it may accelerate DNA degradation of paranchymal tissues of necessary organs. This is nothing new in the world of anticancer agents. I would not advise healthy people to use large doses of ubiquinone without first soberly reflecting on The Law of Unintended Consequences. another flawed study..... > It is very hard to compare worms to people... it is a long shot at best! > > You can Double the Lifespan of rats by feeding them every other day. > So what does that mean? > I would rather be dead than eat every other day. > > also you can take " antioxidants " to combat the " pro-oxidant " effects of > coenzyme Q 10. > > did they try that in the study???? I think not! > > > VGammill wrote: > > > > Researchers More than Double Worms Lifespan > > > > Researchers have more than doubled the lifespan of worms by simply depriving > > them of a micronutrient called coenzyme Q. Drs. Pamela L Larsen and > > F e found that adult worms fed on a coenzyme Q diet lived 59% > > longer than those fed a normal diet. Coenzyme Q is an antioxidant that helps > > to transport electrons during cellular respiration, however Larsen and > > e say that their results suggest that the substance may also have a > > " pro-oxidant " effect. If this is true, reducing the animals' consumption of > > coenzyme Q may extend lifespan by lowering oxidative damage to cells. > > However, the researchers say that it is not possible to lengthen the > > animals' lifespan simply by feeding them a coenzyme Q-free diet from birth, > > as worms fed such a diet were found to be significantly more likely to > > develop reproductive defects. > > > > SOURCE/REFERENCE: Science 2001; 295:120-123 > > > > Get HUGE info at http://www.cures for cancer.ws, and post your own links there. Unsubscribe by sending email to cures for cancer-unsubscribeegroups or by visiting htt > > > > > > Quote Link to comment Share on other sites More sharing options...
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