Oxygen + Cancer Refs

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Hi,

Here are some references to support the use of active oxygen in cancer

therapy, as suggested in Protocol 1.

1: Natl Cancer Inst Monogr 1977 Dec;46:163-9

Hyperbaric oxygen and radiation therapy in the management of glioblastoma.

Chang CH

A pilot clinical trial on radiotherapy of glioblastoma with and without

hyperbaric oxygen was performed at the Columbia-Presbyterian Medical Center.

Eighty previously untreated patients with histologically proved glioblastoma

were evaluated; 38 were irradiated under hyperbaric oxygen and 42 (controls) in

atmospheric air. The survival rates were calculated according to the actuarial

analysis method. At the end of 18 months, the survival rate appeared

considerably higher in the oxygen group (28%) than in the controls (10%). At the

end of 36 months, no patients in the control group survived, whereas 2 patients

in the oxygen group were alive beyond 45 and 48 months, respectively.

PMID: 206835, UI: 78177153

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TI Ozone and gynecologic radiotherapy

AU Hernuss-P; Muller-Tyl-E; Wicke-L

SO Strahlentherapie. 1975 Nov; 150(5): 493-9

ISSN 0039-2073

LA GERMAN

CP GERMANY,-WEST

PT JOURNAL-ARTICLE

UI 76130722

Abstract

Ozone is used in medicine as well as in other spheres. Papers reporting good

results

of ozone treatment in carcinoma seemed of particular interest. The efficacy of

ozone as an adjuvant to the irradiation of carcinosarcomas of rats was confirmed

by us. On account of this fact ozone was introduced by us as an

adjuvant to the irradiation of women with gynaecological cancer and

appeared to give good results. The mechanism of action of ozone is

not yet fully clarified and several theories are discussed.

Investigations are currently being undertaken in respect to the

behaviour of several substances in the organism during ozone therapy.

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TI: Antitumor Effects of Hydrogen Peroxide in vivo.

DT: July 9, 1981

AU: C.F. and Z.A. Cohn

SO: J. Exp. Med, Vol. 154, November 1981, pp 1539-1553

AB: Hydrogen peroxide, a secretory product of mononuclear

phagocytes, accounts for a considerable portion of their

nonphagocytic lysis of tumor cells in at least three

circumstances: when certain secretagogues are added, when

antitumor antibody is present, or when the tumor cells are

coated with eosinophil peroxidase. Granulocytes also

secrete H2O2, which may participate in their cytotoxic

effects in a variety of situations.

In the present study we sought to devise a nontoxic way to

deliver hydrogen peroxide to sites of malignancy in vivo and

to test its antitumor efficacy.

Finally, preformed or enzymatically generated H2O2, with or without a

peroxidase, lyses tumor cells.

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TI: Rationale For Treatment of Cancer with Ozone

DT: 1988

AU: Boguslaw Lipinski, Ph.D.

SO: Boston Cardiovascular Health Center and Tufts University

School of Medicine One Washington Street, Wellesley, MA.

02181

AB: In cancer there is an abnormally high concentration of

artificial, food-derived AOs and low oxygen supply. Under

such conditions there is no lipid peroxidation products

formed and thus no inhibitors are present to control cell

division. This situation, similar to that occurring in the

anaerobic cells can be reversed by introduction of strong

oxidants such as oxygen or ozone in the presence of

sufficient concentration of natural antioxidants (vitamin C

and E). Intraarterial administration of ozone might,

therefore, prove to be an effective treatment for many types

of cancer.

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Ozone Selectively Inhibits Growth of Human Cancer Cells

Science Vol. 209, 22 Aug 1980, pp. 931-933

Abstract:

The growth of human cancer cells from lung, breast, and uterine

tumors was selectively inhibited in a dose-dependent manner by

ozone at 0.3 to 0.8 part per million of ozone in ambient air

during 8 days of culture. Human lung diploid fibroblasts served

as noncancerous control cells. The presence of ozone at 0.3 to

0.5 part per million inhibited cancer cell growth 40 and 60

percent, respectively. The non-cancerous lung cells were

unaffected at these levels. Exposure to ozone at 0.8 part per

million inhibited cancer cell growth more than 90 percent and

control cell growth less than 50 percent. Evidently, the

mechanisms for defense against ozone damage are impaired in

human cancer cells.

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Adv Exp Med Biol 1984;169:613-9

Effectiveness of respiratory hyperoxia, of normobaric and of hyperbaric oxygen

atmospheres in improving tumor oxygenation.

Mueller-Klieser W, Vaupel P, Manz R

Tumor oxygenation during respiratory hyperoxia is dependent on the tumor growth

site, on the growth stage, and hence on the vascular pattern. Diffusion of O2

from the surrounding atmosphere contributes considerably to the oxygenation of

subcutaneous tumors during normobaric exposure to a pure O2 atmosphere. However,

hypoxia (lack of oxygen) is still present in the tumor core under these

conditions,

and pressurization up to 4 bar is required to completely eradicate these hypoxic

areas, thus enhancing the radiosensitivity of the tumors.

PMID: 6731116, UI: 84227650

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Aronoff, B. L. (1965) " " Regional Oxygenation in Neoplasm. "

Cancer. Vol 18.

Gerson, Max. (1990) A Cancer Therapy. Bonita, CA: Gerson

Institute/Pulse.

Samoszuk, M.K. et.al. (1989) " In Vitro Sensitivity of Hodgkins

Disease to Hydrogen Peroxide, " Cancer. Vol. 63.

Sasaki, H., et. al. (1967) " Application of Hydrogen Peroxide

to Maxillary Cancer, " Yonago Acta Medica Vol. 11/3. 109.

Sweet, F. et. a;. (1980) " Ozone Selectivity Inhibits Growth of

Cancer Cells. " Science. Aug 22. 931-932.

Varro, J. (1983) " Ozone Apllications in Cancer Cases, " Medical

Applications of Ozone. Norwalk, Conn: International Ozone

Association, Pan American Committee.

Warburg, Otto.(1966) The Prime Cause and Prevention of Cancer.

Wurzburg: K. Triltsch.

Grunder, H.G., E. Bauer, G. Tramer, E. Utesch. (1976)

" Intravenous Ozone in Irradiated and Non-Irradiated Tumors in Mice. "

Strahlenther, Vol151. 151-154, 480-486,522-529.

Hernuss, P. (1973) " The Effects of Ozone in RadioTherapy for

Tumors in Animal Experiments. " Fortschr auf dem Geb der Roentgenstr

und der Nuklearned.Suppl. 196.

, C.F. and Z. A. Cohn. (1981) " Antitumor Effects of

Hydrogen Peroxide in Vivo, " Journal of Experimental Medicine. Vol.

149.

esu, L., Luzzi, E., Bocci, V., (1990) " Studies on the

Biological Effects of Ozone: Induction of Tumor Necrosis

Factor (TNF-a) on Human Leukocytes. Lymphokine and Cytokine

Research. Vol. 10.5: 409-412.

Teske, H.J., J. Haller, B. Badenber, G. Hoppe (1972)

" Studies of the Effect of Ozone on Tumor Growth and the Action of

Irradiation. " Deutschr. Roentgenkongr. (Stuttgart)

TI Regional hyperoxygenation: an important factor in the

potentiation of antineoplastic chemotherapy

AU Nervi-C; Casale-C; Cortese-M

SO Tumori. 1969 May-Jun; 55(3): 153-9

ISSN 0300-8916

LA ITALIAN

CP ITALY

PT JOURNAL-ARTICLE

UI 70281300

TI Combined therapy of intra-arterial injection of hydrogen

peroxide solution and irradiations in maxillary cancer

AU Sasaki-H; Wakuya-T; Oda-K; Yamazaki-Y

SO Nippon-Jibiinkoka-Gakkai-Kaiho. 1971 Feb; 74(2): 398-9

ISSN 0030-6622

LA JAPANESE

CP JAPAN

PT JOURNAL-ARTICLE

UI 72003396

TI Studies on the effect of ozone on tumor growth and radiation

effect (animal experiments)

AU Teske-HJ; Haller-J; Badenberg-B; Hoppe-G

SO Fortschr-Geb-Rontgenstr-Nuklearmed. 1972: Suppl:12-4

ISSN 0015-8151

LA GERMAN

CP GERMANY,-WEST

PT JOURNAL-ARTICLE

UI 73053628

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