Possible mechanism by which vaccines such as smallpox can predispose to autoimmune illness such as MS

[Guest guest]

From Meryl in 2002

The following abstract reports research that used a recombinant vaccinia

virus as a nonspecific inducer of multiple sclerosis, following challenge

with an agent that showed molecular mimicry to a CNS protein. This could

define a mechanism by which some vaccines increase the risk of subsequent

autoimmune illness.

Vaccinia is the virus that comprises all smallpox vaccines.

Meryl Nass, MD

J Neurovirol 2001 Jun;7(3):220-7 Related Articles, Books, LinkOut

Viruses can silently prime for and trigger central nervous system

autoimmune disease.

Theil DJ, Tsunoda I, F, Whitton JL, Fujinami RS.

Department of Neurology, University of Utah School of Medicine, Salt Lake

City, Utah 84132, USA.

Although many viruses have been isolated from patients with multiple

sclerosis (MS), as yet, no one agent has been demonstrated to cause MS. In

contrast, epidemiological data indicate that viral infections are

associated with exacerbations of MS. Here, we present data showing that

virus infections can subclinically prime animals for central nervous system

(CNS) autoimmune disease; long after the original infection has been

eradicated, a nonspecific challenge/infection can trigger an exacerbation.

The priming infectious agent must show molecular mimicry with self-CNS

antigens such as glial fibrillary acidic protein (GFAP), myelin associated

glycoprotein (MAG) or myelin proteolipid protein (PLP). The subsequent

challenge, however, may be nonspecific; complete Freund's adjuvant (CFA),

or infection with a recombinant vaccinia virus encoding an irrelevant

protein, could trigger CNS disease. In the CNS, we could detect a

mononuclear cell infiltration, but no demyelination was found. However, if

the pathogenesis of MS is similar to that of this novel animal model for

CNS autoimmune disease, our findings could help explain why exacerbations

of MS are often associated with a variety of different viral infections.

PMID: 11517396

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Sheri Nakken, R.N., MA, Classical Homeopath

Vaccination Information & Choice Network, Nevada City CA & Wales UK

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