Guest guest Posted December 7, 2001 Report Share Posted December 7, 2001 They sit there and lie! Dawn in NC ******************************************************** Ask the Experts on . . . Vaccine Overload? http://pediatrics.medscape.com/Medscape/pediatrics/AskExperts/2001/12/PED-ae 28.html ---------------------------------------------------------------------------- ---- Question Is there a danger of " immunological fatigue " with so many vaccines being recommended, ie, can the immune system go on responding to an indefinite number of antigens? Dr. S. Kulkarni Response from Steele, MD, 12/4/01 There is no evidence that the administration of a large number of vaccines given at a single timepoint results in reduced protection as contrasted with giving the vaccines at separate intervals. This issue has been very carefully studied. Going back to the 1970s it was thought that only one vaccine could be given at any particular time. A number of vaccine clinical trials were designed to answer this question, and we are assured that what we are doing is absolutely appropriate for providing maximum protection and optimal health to children. Suggested Reading Halperin SA, King J, Law B, et al. Safety and immunogenicity of Haemophilus influenzae-tetanus toxoid conjugate vaccine given separately or in combination with a three-component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine for the first four doses. Clin Infect Dis. 1999;28:995-1001. Mackay IR, Rosen FS. Vaccines and vaccination. N Engl J Med. 2001;345:1042-1053. G. Childhood immunizations. N Engl J Med. 1992;327:1794-1800. All material on this website is protected by copyright. Copyright © 1994-2001 by Medscape Inc. All rights reserved. Quote Link to comment Share on other sites More sharing options...
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