Vitamin C May Interfere With Chemotherapy Of Cancer Tumors

[Guest guest]

Hello,

Greetings from MindBrain.

I would just once love to read an e mail that is just facts dealing with

prostate cancer or for that fact, any cancer.

You mention in your opening statement, that Vitamin C may, note the word may

not be a good idea to take when undergoing chemo therapy.

Then in the last paragraph, the statement says that more studies have to be

done in order to see what tumor cells do with vitamin C...come on...lets help

us people who have cancer...

Mindbrain.

[Guest guest]

Sometimes, it's not wise to supplement when using Chemo.

Consider the following.

After reading this, I personally concluded that I would not advise on any

nutrition to anyone undergoing chemo.

Do your Chemo, then work like mad to get well. Remember that if you are

using Chemo, that it's going to be more work to clean up the residual drugs

and damage from the drugs. Chemo is not safe, or without complications.

Be well,

Date: Wed, 15 Sep 1999 21:29:43 -0500

From: Webster <michelle@...>

Subject: [NH] Vitamin C May Interfere With Chemotherapy Of Cancer Tumors

Vitamin C May Interfere With Chemotherapy Of Cancer Tumors

Memorial Sloan-Kettering Cancer Center <http://www.mskcc.org>

Contact: Joanne <publicaffairs@...> 212-639-3573

http://www.eurekalert.org/releases/mskc-cts091499.html

9-15-99

Cancer tumors shown to consume large amounts of vitamin C. Researchers are

cautious about cancer patients taking vitamin C supplements .

New York - Researchers at Memorial Sloan-Kettering Cancer Center have found

that cancer tumors consume large amounts of vitamin C. Their findings,

which are reported in the September 15 issue of Cancer Research, may shed

new light on the nutritional needs of tumors.

" This study is the first to demonstrate exactly how cancer cells acquire

large quantities of vitamin C, " said Dr. Golde, senior author of the

study and Physician-in-Chief of Memorial Hospital.

Although the role that vitamin C plays in tumors is not yet known, recent

studies have shown that there may be possible

interactions between dietary antioxidants and chemotherapy treatment.

Vitamin C is a powerful antioxidant that consumes free radicals - or toxic

substances in the body that can also be generated from chemotherapy agents

to destroy cancer cells.

" It's possible that taking large amounts of vitamin C could interfere with

the effects of chemotherapy or even radiation

therapy, since these therapies often kill cells in part by using oxidative

mechanisms. It's conceivable then, that vitamin C

might make cancer treatment less effective and therefore, reasonable that

cancer patients undergoing chemotherapy

should avoid taking large amounts of this vitamin, " said Dr. Golde.

Earlier research by Dr. Golde and his colleagues had established that

specific glucose transporter molecules were

responsible for transporting vitamin C into cells. This process ascorbic

acid, is converted into the form of dehydroascorbic acid and transported

into the cell. Once inside, the vitamin is converted back to ascorbic acid.

This discovery prompted Dr. Golde's team to explore whether glucose

transporter molecules and vitamin C might function in cancer cells, as

malignant cells devour more glucose than normal cells to obtain the energy

they need to grow. Subsequently, their laboratory studies with myeloid

leukemia cells showed that the cells accumulated high levels of vitamin C

through their glucose transporters.

Building on this research, the researchers hypothesized that human

leukemia, breast and prostate cancer cells would acquire large amounts of

vitamin C in the same way. To find out, mice were injected with human

cancer cells of the breast, prostate and blood and, after tumors had

developed, were injected with ascorbic acid, dehydroascorbic acid, or

sucrose (as a measure of blood volume). All tumors were subsequently

analyzed for vitamin C content. The researchers found that the tumors

readily took up vitamin C by a process involving the conversion of ascorbic

acid to dehydroascorbic acid.

" Now we know that tumors acquire and retain large amounts of vitamin C. So,

it appears that tumors have nutritional needs, similar to other healthy

cells that take in large amounts of the vitamin, " said Dr. Agus,

first author of the study and an oncologist at Memorial Sloan-Kettering

Cancer Center. " More studies need to be done to determine what the tumor

cells do with the vitamin C once they get it. "

____________

Memorial Sloan-Kettering Cancer Center is the world's oldest and largest

private institution devoted to prevention, patient care, research, and

education in cancer. Throughout its long distinguished history, the Center

has played a leadership role in defining the standard of care for patients

with cancer. In 1999, Memorial Sloan-Kettering was named the nation's best

cancer care center for the seventh consecutive year by U.S. News and World

Report.

[Guest guest]

Hello MindBrain,

Her is somethin I think you will find interesting.

INTERESTING.

A PILOT SURVEY: STANDARD CANCER THERAPY COMBINED WITH NUTRACEUTICAL DIETARY

SUPPLEMENTATION IMPROVES TREATMENT RESPONSES AND PATIENT QUALITY OF LIFE G.Hyl

and, M.D.,D.,M.T, Medcenter One, Dept. Radiation Oncology, Bismarck,

North Dakota.

In thousands of cancer cases evaluated by H. , 87% of those with

" spontaneous remissions " had made major dietary changes prior to tumor

regression. The Dietary Supplement Health Education Act of 1994 resulted in

millions of US citizens adding a plethora of supplements to their diets. A

favorable response by 5 patients that failed all cancer therapy was noted

after it was stopped. We found that they had consumed phytonutrient and

phytogenin containing dietary supplements. A search revealed that Busbee et.

al 1994 found a glyconutrient in these diet supplements increased

IL-1,IL-6,INF andTNF production in monocyte cultures. See et. al 1999

reported enhanced NK lymphocyte cytolytic function in response to multiple

glyconutrients. Barhomi et. al 1997 found glyconutriens increased

intracellular reduced-glutathione protection 50% in liver cells. Such

activity provides a potentioal differential effect for tumor cell destruction

and normal cell protection. To increase our observations, patients with

malignancies were solicited from a 3 state area and 127 volunteered to add

nutraceuticals to their diet. 100 patients returned a quality of life survey

focusing on weight loss, fatigue, nausea, vomiting, pain control, ability to

complete treatments on schedule, physical activity and sense of well being.

40% of the group had failed standard therapy and were in a state of

progressive disease. 60% were starting radiation or chemo-therapy. 85%

reported improvements in the above clinical perameters. The phytogenin

supplement contains plant sterols for nutrient based endocrine support.

Ovarian, breast, uterine, and prostate malignancy patients werediscouraged

from taking this nutrient. Some elected to add the phytogenin to their diet

and they reported the best preservation of appetite, muscle mass, and had the

least side-effects during treatment. Patients with a diagnoses of ovarian

carcinoma, astrocytoma grade IV, lymphoma with mild marrow suppression, a

massive pelvic myxosarcoma, and colon adenocarcinoma with brain metastasis

had unprecendented responses. Conclusions: Nutraceutical dietary supplements

(1) do not inhibit tumor cell destruction by radiation and chemotherapy (2)

enhance tumor cell destruction (3) protect normal cells from radiation and

cytotoxic damage (4) induce reductions in tumor mass in malignancies

resistant to all treatments (5) improve quality of life for patients by

reducing treatment toxicity and side effects from radiation and chemotherapy.

A formal, controlled clinical study is warranted to further evaluate the

effects of nutraceutical dietary supplementation in combination with standard

cancer therapy.

Fisher institute for Medical Research, P.O. Box 530689, Grand Prairie Texas

75053 E-mail helen@... (972) 660-3219 FAX (972) 660-1245

[Guest guest]

I didn't say a thing. I posted, in it's entirety, an article.

Be well,

At 06:02 PM 01/26/2000 EST, you wrote:

>Hello,

>Greetings from MindBrain.

>

>I would just once love to read an e mail that is just facts dealing with

>prostate cancer or for that fact, any cancer.

>

>You mention in your opening statement, that Vitamin C may, note the word may

>not be a good idea to take when undergoing chemo therapy.

>

>Then in the last paragraph, the statement says that more studies have to be

>done in order to see what tumor cells do with vitamin C...come on...lets

help

>us people who have cancer...

>

>Mindbrain.

>

>

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