Two falling iron balls

[Guest guest]

On November 22, 1999, this letter was first posted to the e-mail resource 'cures for canceregroups'.

www.jsr1936.com The Cure for Cancer? jsr1936@...

I believe that enlightenment comes about with the sharing of ideas, opinions and facts.

Socrates said it best-

" The only good is knowledge and the only evil is ignorance. "

CANCER -

My fellow citizens, I hope you are as curious as I am about the answers which will be forthcoming from the medical community about Thioproline/Cancer.

I have been waiting two years for an answer from the National Institutes of Health (NIH), and thus far the silence is deafening. This letter is being e-mailed to Harold Varmus, M.D., Director, National Institutes of Health (NIH) execsec1@....

The 'ghost' of the Spanish study continues to haunt cancer research; I wasn't even looking for it; I stumbled upon it at about 3:15 P.M., Tuesday, September 9, 1997; my primary research at the time was HIV/AIDS; cancer was the furthest thought from my mind.

Every Monday I shall post to this Internet resource, cures for canceregroups, this letter and the following letters -

1. 'To Dr. Varmus, Director, National Institutes of Health (NIH)', first posted to cures for canceregroups on November 7, 1999

2. 'San Diego Clinic - Dr. Vazquez, sdc12@...', first posted November 14

3. 'Response to a critic', first posted November 15

4. ' Gammill/ S. Debate', first posted November 16

5. 'Congressional Committee to investigate NIH', first posted November 17

6. 'Pure' Thioproline - Not 'Equal' and L-cysteine', first posted November 19

7. 'Inspiration to write letters', first posted November 20.

If this is unnecessarily repetitive and counter-productive, I shall follow the guidance and will of this e-group owner, Mr. Bob Hurt, as to how he wants me to proceed.

I will cease these postings only if medical clinical trials prove me wrong.

Until then, I want the world to come to the realization that there exists within The Internet a resource which describes every week possible cures for cancer and chronic myelogenous leukemia (CML) and describes every week possible ways to lessen the ravages of HIV/AIDS, Alcohol Abuse, Lou Gehrig's Disease, and Macular Degeneration, and that source is cures for canceregroups.

This letter repeats several passages from the aforementioned letters; however I feel the need to post all of them in their entirety.

I think that these eight letters are a pretty good distillation of all that I have posted to this e-group (42 letters in total). My first letter posting began on August 21, 1999; it was a response to Gammill's, Sc.D., criticism of passages from my website www.jsr1936.com.

My answer to 's most recent criticism -

To Gammill, Sc.D.,

, if it had not been for your posting of November 20, 'Re:Inspiration to write letters--J.S.', this letter would never have been written.

, thank you.

, I don't know whether this story is true, but let's assume it is.

The Italian astronomer and physicist, Galileo (1564-1642), maintained that if two iron balls of different sizes and weights were dropped from any height they would both land on the ground at the same time.

The learned men of the time, followers of Aristotle, who said that heavy bodies fell faster than lighter ones, bitterly opposed Galileo's new theory.

The learned men laughed and said, " You are insane, Galileo. Everybody knows that the heavier ball will be the first to hit the ground. "

Galileo said, " All right gentlemen, let's just see. "

And then Galileo showed them two iron balls. One was a cannon ball about the size of a bowling ball, and the other iron ball was no larger than that of a golf ball.

Galileo said, " Gentlemen, please accompany me to the Leaning Tower of Pisa. I'll ascend the tower, and since it is leaning, you can clearly see me at the top. Please observe that I will be dropping the balls at the same time. Several of you gentlemen can accompany me to the top of the tower to observe me to make sure that I am not applying any added force when I release the balls. I will simply open my hands and let the balls fall of their own weight. "

The learned men agreed.

Galileo called out from the top of the tower to the men below, " Gentlemen, are you ready to observe? "

The learned men at the base of the tower laughed back their reply, " Yes indeed, Galileo. Oh, you are such a fool! "

Galileo let loose of the balls, and lo and behold! - the balls hit the ground at the same time; there was no variance whatsoever.

The learned men did not know what to say. They were dumbfounded.

A simple experiment proved whether Galileo was right or wrong.

, this is all that I have been imploring the National Institutes of Health (NIH) to do throughout the past two years - drop the balls - that is to say - repeat, with modifications, a clinical trial in which these results were obtained when Thioproline was administered to cancer patients -

" .....Histological studies showed involution and transformation into low-grade malignancies and disappearance of evidence of cancer. "

Thioproline " .....had a considerable antitumour effect in epidermoid carcinoma of the head and neck. Definite signs of activity were observed in epidermoid carcinoma of other regions and in other solid tumours, such as breast, renal, ovary, thyroid, and parotid cancer. "

My fellow citizens - reflect for a moment - A clinical trial was conducted 20 years ago in which human beings were administered Thioproline. This is an established medical event which is recorded in one of the foremost and prestigious medical journals of the world - 'The Lancet', January 12, 1980, pages 68 to 70.

I am simply asking, and this is all that I have been asking for since November, 1997, that this trial be repeated, but this time 'mega-doses' of Thioproline and vitamin C and 'above average' amounts of magnesium, zinc, and manganese would be administered to the patients orally.

My suggestion for the protocol - why not follow that of the original clinical trial - from letter No. 2 -

" The criteria used in the selection of patients were: pathological diagnosis of advanced cancer resistant to treatment; physical condition allowing outpatient care; measureable tumour for evaluation of the response; no other cancer treatment in the 4 weeks before, or during thioproline treatment; and informed consent by patients. "

" Clinical assessment included history and examination, measurement of tumours, chest X-ray, ECG, complete blood counts, liver profile, and urine analysis. These assessments were made before treatment began, and every 1-3 weeks during treatment. "

Would it be fair to ask for a clinical trial of one month duration?

The cancer patients would swallow these substances daily;see page 7 to 9 (left hand side pagination) of www.jsr1936.com for further details:

1. 10,000 mg. of vitamin C (ascorbic acid). Mr. Jerry Rollins bought the 'NOW' brand - not timed release.

2. 3 tablets containing magnesium, zinc and manganese. 'NOW' sells " Full Spectrum Minerals " which contains these elements

3. 40 mg/kg. of Thioproline. Twenty years ago only 5mg/kg. of this acid was orally administered. Not much of a result was achieved. But guess what? The one case where they did get a result was renal (kidney) cancer. It is my understanding that this cancer is almost impossible to cure.

The one variable will be the maximum amount of Thioproline which can be swallowed.

The Lethal Dosage amount of Thioproline is 210 mg/kg.

I wish to suggest that vitamin C would afford enough protection to allow the administration of this amount. Indeed, perhaps double this amount could be administered - 420 mg/kg. Indeed, perhaps triple this amount could be administered - 630 mg/kg.

The following is Jerry Rollins' experience after subjecting himself to 'mega-doses' of Thioproline (which he generated in his body by swallowing 'Equal' and L-cysteine); this is his September 5, 1999 posting to cures for canceregroups; he had directed it to another member of the group who has prostate cancer -

" I appreciate your comments and - So....for better or worse I'm finished with the 12 day ' Cure'. Except for the closely scheduled regimen it was not harmful in anyway I can as yet determine.No kidney aches, bladder strain, headache, upset stomach....as a matter of fact I don't see how it can do me any good if there's not some suffering. Isn't that a fact of life...no gain without pain? Tuesday I'll have a PSA test so we'll all see. Won't it be fantastic if I can stop cantron, etc. and not worry about debilitating hormone followed by chemo. Of course the '12 day' is chemo but apparently a harmless and quick one. It's nice to know there are many out there monitoring my progress. If it's worked all I'll need do is to take what's necessary to keep my immune system in top shape. "

S. - I am not at all happy with the evidence which has been assembled against Thioproline. I would be generous if I called it 'scanty'.

I would like for an investigative committee of Congress to ask Dr. Varmus and other National Institutes of Health officials if my No. 1 letter pretty much includes the totality of the negativity which has surfaced against Thioproline.

If this be the case, I am shocked, dumbfounded and dismayed that the paucity of research which I cite in Letter No. 1 constituted the basis for abnegating interest in a compound which showed such glowing promise.

Unless there are facts 'out there' of which I am not aware, I am forced to conclude with a sense of amazement that the medical community of the world has had at its disposal for the past 20 years a possible cure for cancer but has not done anything to promote its development.

The following information is found in letter No. 1 -

In answer to his critics the co-author of the Spanish study stated:

" .....However, reports of our later work given at scientific meetings or in the pipeline, confirm that thioproline does induce reverse transformation and that the whole concept, despite its complexities, is promising. "

In this decade Professor V. Schally, a Nobel Laureate, and his colleagues have achieved amazing laboratory results with a compound which incorporates Thioproline -

" .....Since antagonists of this class (j.s.r. -containing Thioproline) inhibit growth of various tumors in animal cancer models, some of them may have clinical applications. "

" .....BN antagonists such as RC-3950-II (j.s.r. - containing Thioproline) may have important therapeutic applications for the treatment of various malignancies such as prostatic, gastric, and pancreatic cancer, small cell lung carcinoma, and other tumors. "

THIS JUST OCCURRED TO ME AS I WRITE THIS LETTER TODAY, NOVEMBER 22, 1999 - WHAT DOES PROFESSOR SCHALLY MEAN WITH THE WORDS - " .....INHIBIT GROWTH OF VARIOUS TUMORS IN ANIMAL CANCER MODELS..... " ?

Refer to Letter No. 1; refer to the letter in it written by 'T.F. Slater'; this might be the most important document of them all; I am not a biochemist, and I do not understand much of it, but I found this passage intriguing (remember that Thioproline is Thiazolidine-4-carboxylic acid) -

" .....The thiazolidine and furan derivatives produced by interaction of 4-hydroxy-alk-2-en-1-als with cysteine have been studied over many years for anti-tumour action on animal tumours, and some of the parent hydroxy-unsaturated aldehydes have also been tested on human cancer. "

Professor Schally and his colleagues: " .....INHIBIT GROWTH OF VARIOUS TUMORS IN ANIMAL CANCER MODELS..... "

T.F. Slater: " .....ANTI-TUMOUR ACTION ON ANIMAL TUMOURS..... "

These passages are from my No. 6 letter, but they bear repeating at this time because I have added some dates -

" When the investigative committee of the Congress of the United States of America convenes, I hope to see answers to these questions from Dr. Varmus and other health officials of the National Institutes of Health -

In 1979 it was published that the National Cancer Institute initially sponsored research on Thioproline (contract NO1-CM-53792) which lead to a clinical trial involving human beings in Spain.

Glowing results were obtained and reported in January, 1980.

Why didn't the National Cancer Institute sponsor a clinical trial in the United States which would have investigated Thioproline's effectiveness upon human beings?

Later in 1980 why was the National Cancer Institute content to sponsor research (grant CA-24543, Contract NO1-CM-97278) in which experiments were merely done upon rats and mice?

Dr. Varmus, I assume the National Cancer Institute (NCI) conducted meetings to compare and contrast the research which I have thus far cited (Letter No. 1). Am I over-looking any other important studies which the NCI may have taken into consideration?

Dr. Varmus, are minutes of those meetings available which could be made public to the American populace?

Dr. Varmus, on what basis did the NCI decide to discontinue efforts to investigate the possibilities of the Brugarolas/Gosalvez research? What was the key factor which abnegated interest in Thiazolidine-4-carboxylic acid (Thioproline) as an anti-cancer agent? Could it have been its toxicity?

In addition, the committee should obtain from the NIH the reason why no definitive answer has ever been rendered to my proposal that a new clinical trial should be initiated to explore the anti-cancer possibilities of 'mega-doses' of Thioproline and vitamin C (ascorbic acid) and 'above average' amounts of magnesium, zinc and manganese.

I have been continually making this proposal to the NIH since November 23, 1997; refer to the last page of www.jsr1936.com; that picture was published in the newspaper on February 14, 1999; since that time I have written numerous additional letters to the NIH imploring it to do an anti-cancer clinical trial in the manner I describe.

As I write this letter today, I have still not received a definitive response from the NIH. "

Finally, I would like the investigative committee of Congress to ask Dr. Varmus and two or three other officials of the NIH, who I have previously written to but never received a received a response, this simple question -

" In their opinion, would it be worthwhile to repeat the Spanish clinical trial in the manner I describe. If their answer is 'No', what is their reasoning?

My fellow citizens, my research show how the Ascorbic Acid Flush negates the toxicity of Thioproline. This medical procedure could provide mankind with the golden key to unlock the power of Thioproline. If I speak the truth, if the body is 'saturated' with vitamin C (ascorbic acid), 'mega-doses' of Thioproline could be swallowed.

Sources and prices of Thiazolidine-4-carboxylic acid (Thioproline) -

Sigma-Aldrich cost of 10 grams - $11.80

P.O. Box 355 cost of 100 grams - $64.80

Milwaukee, Wisconsin 53201

phone (800) 771-6737, extension 5343

FAX (414) 273-4979

Alfa Aesar cost of 10 grams - $7.80

A Matthey Catalog Company, Inc. cost of 50 grams - $29.80

30 Bond Street cost of 250 grams - $132.00

Ward Hill, Massachusetts 01835-8099

phone (978) 521-6300

A Sigma-Aldrich company official has told me that they could supply the acid to the patient's physician; however, first the physician would have to file an 'Investigative New Drug Application' with the Food and Drug Administration (FDA).

After the patient's physician had obtained FDA approval, Sigma-Aldrich could send the acid to that physician and be in accordance with the law.

The Alfa Aesar company official said that the acid could be supplied to legitimate researchers but was noncommital about the possibility of supplying it to the physician of the patient.

The acid is chemically easy to make and the process is not dangerous. In addition, no one's patent right would be infringed upon if a person chose to make it or chose to have a knowledgeable high school chemistry student make it. See page 7 of www.jsr1936.com.

I wish to remind everyone that out of the over 9,000,000 entries contained in 'MedLine', Thioproline (Thiazolidine-4-carboxylic acid) is one of the very few substances which is specifically labelled as being 'anti-cancer' (see pages 3 and 4 of www.jsr1936.com).

CHRONIC MYELOGENOUS LEUKEMIA (CML) -

Thanks to Mrs. Judy Singer, a member of cures for canceregroups, a became aware of the word, 'penicillamine' in late August, 1999.

If you type " Penicillamine and Leukemia " into 'Medline' (www.ncbi.nlm.nih.gov/pubmed) you will find that there are 23 entries (as of November 22) which are devoted to this subject. I have found the following one to be the most interesting; the Unique Identifier number is 96273151; I have taken one sentence from it:

" .....Human acute myelogenous leukemia cells were especially sensitive to PSH plus copper..... " PSH is d-penicillamine.

A relationship exists between Penicillamine and Thiazolidine-4-carboxylic acid (Thioproline).

The 1999 edition of the PHYSICIAN'S DESK REFERENCE (PDR) states on page 1766 that penicillamine " reacts readily with formaldehyde or acetone to form a thiazolidine-4-carboxylic acid. "

I will state unequivocally that the " thiazolidine-carboxylic acid " which the PDR mentions is the same as that which I cite on pages one and two of www.jsr1936.com. I challenge the scientific and medical community of the world to refute me.

Since vitamin C (ascorbic acid) protects against the toxicity of Thiazolidine-4-carboxylic acid, might it also protect against the toxicity of penicillamine?

On about October 12, 1999, I called Dr. Cathcart's office; I believe Dr. Cathcart is a former associate of Dr. Linus ing; Dr. Cathcart's website is www.orthomed.com and it reads:

'ORTHOMOLECULAR MEDICINE

VITAMIN C

ROBERT F. CATHCART, M.D.

and left this question - " Does vitamin C afford protection against the toxicity of penicillamine? "

The next day Dr. Cathcart's secretary called me and said that, " Dr. Cathcart doesn't have any personal experience with what you mentioned, but in theory he could see how vitamin C could protect against penicillamine. "

1. A scientific fact - Human acute myelogenous leukemia cells are especially sensitive to d-penicillamine plus copper.

2. A scientific opinion - Vitamin C could possibly protect against penicillamine.

3. A scientic hypothesis - 'Mega-doses' of d-penicillamine plus copper and vitamin C will cure chronic myelogenous leukemia.

Would the National Institutes of Health (NIH) be interested in giving this hypothesis a clinical trial? Is the NIH willing to see the two iron balls drop?

HIV/AIDS -

It is my hope that the investigative committee of Congress will ascertain the thoughts of Ms. Thurman about my proposal to utilize L-2-Methylthiazolidine-4-carboxylic acid (L-MTCA) and N-Acetyl Cysteine (NAC) as an anti-HIV agent.

Ms. Thurman is the Director, National Aids Policy Office, and the details about L-MTCA and NAC are in www.jsr1936.com.

Alcohol Abuse -

It is my hope that the investigative committee of Congress will ascertain the thoughts of Satcher, M.D., Ph.D., about my proposal to add this third statement to the alcohol warning label -

(3) PROPER METABOLISM OF ALCOHOL REQUIRES THE INGESTION OF ABOVE AVERAGE AMOUNTS OF ZINC, VITAMIN B-6 AND VITAMIN C.

All of the details are in www.jsr1936.com.

I would be willing to bet that not one drinker in a million is aware of the critical need of zinc in his or her diet; could a deficiency of this element in the diet be the precursor to the development of alcoholism if a person is a habitual drinker of alcohol?

Dr. Satcher is Surgeon General of the United States of America.

Lou Gehrig's Disease -

See page 19 of www.jsr1936.com.

Macular Degeneration -

See pages 19 and 20 of www.jsr1936.com.

My fellow citizens, farewell for now. Your Congressman is just a telephone call away.

Yours truly, S. , P.O. Box H, Hobart, Indiana 46342 (219) 763-1933

e-mail copy to Harold Varmus, M.D., Director, National Institutes of Health (NIH), Bethesda, land,

execsec1@..., (301) 496-2433

Mail copies to -

President Clinton, The White House, Washington, D.C.

Ms. Thurman, Director, National Aids Policy Office, The White House, Washington, D.C.

Donna E. Shalala, Ph.D., Secretary of Health and Human Services, Washington, D.C.

Satcher, M.D., Ph.D., Surgeon General of the United States of America, Rockville, land

Harold Varmus, M.D., Director, National Institutes of Health (NIH), Bethesda, land

Professor V. Schally, Veterans Affairs Medical Center, New Orleans, Louisiana

F. Cathcart, M.D., 'Orthomolecular Medicine', Los Altos, California

Mr. Jon Huntsman and M. Prescott, M.D., Executive Director,

'Huntsman Cancer Institute', Salt Lake City, Utah

Dr. Vazquez, San Diego Clinic, sdc12@..., California

Dr. Hulda , 'Self Health Resource Center', Chula Vista, California

e-mail copies to various persons