Guest guest Posted February 8, 2010 Report Share Posted February 8, 2010 yes Cozaar can increase renin. The post dex aldo means you don't have GRA. Good news.Never give me a reading of "normal". I need the numbers. If you salt intake was much lower that the first measurement then that will also increase renin.But it would have to be a lot lower so need to know that the Na (and K) was. CE Grim MDOn Feb 8, 2010, at 6:15 PM, Dana wrote:Dr. Grim now I am totally confused. I got my blood work back today but have not talked to the endo docs yet. In Mid-November my Aldo was 4.9 (4-31) and my Renin was <0.15 (1.31-3.95) The results I got back today are the following Aldo (post dex suppression) 3.3 (1-16) and my Renin was 7.59 (0.15-2.33) the normals are a little different because this time they had me laying down for 15 minutes prior to the blood draw because they were also taking blood for plasma free metanephrines. The difference medication wise is that in November I was on 50mg of Cozaar and 20mg of Nadolol and now I am on 100mg Cozaar and 40mg of Coreg CR.The urine NA was normal, Cl was low 74 (110-250), and we don't have the Potassium back yet.I am just a little confused on how my renin can go from being extremely low <0.15 to being so high of 7.59. Is Cozaar affecting the results and just confusing the issue? Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2010 Report Share Posted February 8, 2010 Sorry about the normal comment NA was 74 (40-220) the problem is I don't have a NA value from the first time. Dana Sent from my Verizon Wireless BlackBerryFrom: Clarence Grim <lowerbp2@...>Date: Mon, 08 Feb 2010 18:36:36 -0600<hyperaldosteronism >Subject: Re: Blood Results yes Cozaar can increase renin. The post dex aldo means you don't have GRA. Good news.Never give me a reading of "normal". I need the numbers. If you salt intake was much lower that the first measurement then that will also increase renin.But it would have to be a lot lower so need to know that the Na (and K) was. CE Grim MDOn Feb 8, 2010, at 6:15 PM, Dana wrote:Dr. Grim now I am totally confused. I got my blood work back today but have not talked to the endo docs yet. In Mid-November my Aldo was 4.9 (4-31) and my Renin was <0.15 (1.31-3.95) The results I got back today are the following Aldo (post dex suppression) 3.3 (1-16) and my Renin was 7.59 (0.15-2.33) the normals are a little different because this time they had me laying down for 15 minutes prior to the blood draw because they were also taking blood for plasma free metanephrines. The difference medication wise is that in November I was on 50mg of Cozaar and 20mg of Nadolol and now I am on 100mg Cozaar and 40mg of Coreg CR.The urine NA was normal, Cl was low 74 (110-250), and we don't have the Potassium back yet.I am just a little confused on how my renin can go from being extremely low <0.15 to being so high of 7.59. Is Cozaar affecting the results and just confusing the issue? Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2010 Report Share Posted February 8, 2010 Now I need to know if this is the Na concentration/L or the total amount in the 24 hr urine. If the total amount then it is lower than most folks. If a concentration multiply this by your urine volume in the collection to get amount excreted (and eaten). Use the following notation when talking about Na in urine [Na] = sodium concentration as in mM/L or mEq/L ENA = sodium excreted. Should be E with the Na as a subscript but can't seem to do this in my email. UV = urine volume ENa = [Na] x UV Clarence E. Grim, BS, MS, MD Specializing in Primary Aldosteronism, Difficult High Blood Pressure and recent evolutionary forces on high blood pressure in populations today. On Monday, February 08, 2010, at 06:43PM, <cowdoc@...> wrote: > Sorry about the normal comment NA was 74 (40-220) the problem is I don't have a NA value from the first time. Dana Sent from my Verizon Wireless BlackBerry From: Clarence Grim <lowerbp2mac> Date: Mon, 08 Feb 2010 18:36:36 -0600 <hyperaldosteronism > Subject: Re: Blood Results yes Cozaar can increase renin. The post dex aldo means you don't have GRA. Good news. Never give me a reading of "normal". I need the numbers. If you salt intake was much lower that the first measurement then that will also increase renin. But it would have to be a lot lower so need to know that the Na (and K) was. CE Grim MD On Feb 8, 2010, at 6:15 PM, Dana wrote: Dr. Grim now I am totally confused. I got my blood work back today but have not talked to the endo docs yet. In Mid-November my Aldo was 4.9 (4-31) and my Renin was <0.15 (1.31-3.95) The results I got back today are the following Aldo (post dex suppression) 3.3 (1-16) and my Renin was 7.59 (0.15-2.33) the normals are a little different because this time they had me laying down for 15 minutes prior to the blood draw because they were also taking blood for plasma free metanephrines. The difference medication wise is that in November I was on 50mg of Cozaar and 20mg of Nadolol and now I am on 100mg Cozaar and 40mg of Coreg CR. The urine NA was normal, Cl was low 74 (110-250), and we don't have the Potassium back yet. I am just a little confused on how my renin can go from being extremely low <0.15 to being so high of 7.59. Is Cozaar affecting the results and just confusing the issue? Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2010 Report Share Posted February 8, 2010 I am sorry about the unclear information sodium concentration was 34 MEQ/L and the sodium excretion was 74 MEQ/24 HRS. Total urine volume for the 24 HRS was 2170 ml. DanaSent from my Verizon Wireless BlackBerryFrom: lowerbp2 <lowerbp2@...>Date: Mon, 08 Feb 2010 20:02:43 -0600<hyperaldosteronism >Subject: Re: Blood Results Now I need to know if this is the Na concentration/L or the total amount in the 24 hr urine. If the total amount then it is lower than most folks. If a concentration multiply this by your urine volume in the collection to get amount excreted (and eaten).Use the following notation when talking about Na in urine[Na] = sodium concentration as in mM/L or mEq/LENA = sodium excreted. Should be E with the Na as a subscript but can't seem to do this in my email. UV = urine volumeENa = [Na] x UVClarence E. Grim, BS, MS, MDSpecializing in Primary Aldosteronism, Difficult High Blood Pressure and recent evolutionary forces on high blood pressure in populations today.On Monday, February 08, 2010, at 06:43PM, <cowdocsbcglobal (DOT) net> wrote:> Sorry about the normal comment NA was 74 (40-220) the problem is I don't have a NA value from the first time. Dana Sent from my Verizon Wireless BlackBerryFrom: Clarence Grim <lowerbp2mac>Date: Mon, 08 Feb 2010 18:36:36 -0600<hyperaldosteronism >Subject: Re: Blood Results yes Cozaar can increase renin. The post dex aldo means you don't have GRA. Good news.Never give me a reading of "normal". I need the numbers. If you salt intake was much lower that the first measurement then that will also increase renin.But it would have to be a lot lower so need to know that the Na (and K) was. CE Grim MDOn Feb 8, 2010, at 6:15 PM, Dana wrote:Dr. Grim now I am totally confused. I got my blood work back today but have not talked to the endo docs yet. In Mid-November my Aldo was 4.9 (4-31) and my Renin was <0.15 (1.31-3.95) The results I got back today are the following Aldo (post dex suppression) 3.3 (1-16) and my Renin was 7.59 (0.15-2.33) the normals are a little different because this time they had me laying down for 15 minutes prior to the blood draw because they were also taking blood for plasma free metanephrines. The difference medication wise is that in November I was on 50mg of Cozaar and 20mg of Nadolol and now I am on 100mg Cozaar and 40mg of Coreg CR.The urine NA was normal, Cl was low 74 (110-250), and we don't have the Potassium back yet.I am just a little confused on how my renin can go from being extremely low <0.15 to being so high of 7.59. Is Cozaar affecting the results and just confusing the issue? Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2010 Report Share Posted February 8, 2010 Dr. Grim is there any significance to the low chloride? CL concentration was 34 mEq/L and CL excretion was 74 mEq/ 24 HRS the same as the sodium. Lab error maybe? DanaSent from my Verizon Wireless BlackBerryFrom: lowerbp2 <lowerbp2@...>Date: Mon, 08 Feb 2010 20:02:43 -0600<hyperaldosteronism >Subject: Re: Blood Results Now I need to know if this is the Na concentration/L or the total amount in the 24 hr urine. If the total amount then it is lower than most folks. If a concentration multiply this by your urine volume in the collection to get amount excreted (and eaten).Use the following notation when talking about Na in urine[Na] = sodium concentration as in mM/L or mEq/LENA = sodium excreted. Should be E with the Na as a subscript but can't seem to do this in my email. UV = urine volumeENa = [Na] x UVClarence E. Grim, BS, MS, MDSpecializing in Primary Aldosteronism, Difficult High Blood Pressure and recent evolutionary forces on high blood pressure in populations today.On Monday, February 08, 2010, at 06:43PM, <cowdocsbcglobal (DOT) net> wrote:> Sorry about the normal comment NA was 74 (40-220) the problem is I don't have a NA value from the first time. Dana Sent from my Verizon Wireless BlackBerryFrom: Clarence Grim <lowerbp2mac>Date: Mon, 08 Feb 2010 18:36:36 -0600<hyperaldosteronism >Subject: Re: Blood Results yes Cozaar can increase renin. The post dex aldo means you don't have GRA. Good news.Never give me a reading of "normal". I need the numbers. If you salt intake was much lower that the first measurement then that will also increase renin.But it would have to be a lot lower so need to know that the Na (and K) was. CE Grim MDOn Feb 8, 2010, at 6:15 PM, Dana wrote:Dr. Grim now I am totally confused. I got my blood work back today but have not talked to the endo docs yet. In Mid-November my Aldo was 4.9 (4-31) and my Renin was <0.15 (1.31-3.95) The results I got back today are the following Aldo (post dex suppression) 3.3 (1-16) and my Renin was 7.59 (0.15-2.33) the normals are a little different because this time they had me laying down for 15 minutes prior to the blood draw because they were also taking blood for plasma free metanephrines. The difference medication wise is that in November I was on 50mg of Cozaar and 20mg of Nadolol and now I am on 100mg Cozaar and 40mg of Coreg CR.The urine NA was normal, Cl was low 74 (110-250), and we don't have the Potassium back yet.I am just a little confused on how my renin can go from being extremely low <0.15 to being so high of 7.59. Is Cozaar affecting the results and just confusing the issue? Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2010 Report Share Posted February 9, 2010 All Chloride comes from salt. So if you were on a low sodium diet that would do it unless you lost some urine. CE Grim MD Clarence E. Grim, BS, MS, MD Specializing in Primary Aldosteronism, Difficult High Blood Pressure and recent evolutionary forces on high blood pressure in populations today. On Monday, February 08, 2010, at 08:20PM, <cowdoc@...> wrote: > Dr. Grim is there any significance to the low chloride? CL concentration was 34 mEq/L and CL excretion was 74 mEq/ 24 HRS the same as the sodium. Lab error maybe? Dana Sent from my Verizon Wireless BlackBerry From: lowerbp2 <lowerbp2mac> Date: Mon, 08 Feb 2010 20:02:43 -0600 <hyperaldosteronism > Subject: Re: Blood Results Now I need to know if this is the Na concentration/L or the total amount in the 24 hr urine. If the total amount then it is lower than most folks. If a concentration multiply this by your urine volume in the collection to get amount excreted (and eaten). Use the following notation when talking about Na in urine [Na] = sodium concentration as in mM/L or mEq/L ENA = sodium excreted. Should be E with the Na as a subscript but can't seem to do this in my email. UV = urine volume ENa = [Na] x UV Clarence E. Grim, BS, MS, MD Specializing in Primary Aldosteronism, Difficult High Blood Pressure and recent evolutionary forces on high blood pressure in populations today. On Monday, February 08, 2010, at 06:43PM, <cowdocsbcglobal (DOT) net> wrote: > Sorry about the normal comment NA was 74 (40-220) the problem is I don't have a NA value from the first time. Dana Sent from my Verizon Wireless BlackBerry From: Clarence Grim <lowerbp2mac> Date: Mon, 08 Feb 2010 18:36:36 -0600 <hyperaldosteronism > Subject: Re: Blood Results yes Cozaar can increase renin. The post dex aldo means you don't have GRA. Good news. Never give me a reading of "normal". I need the numbers. If you salt intake was much lower that the first measurement then that will also increase renin. But it would have to be a lot lower so need to know that the Na (and K) was. CE Grim MD On Feb 8, 2010, at 6:15 PM, Dana wrote: Dr. Grim now I am totally confused. I got my blood work back today but have not talked to the endo docs yet. In Mid-November my Aldo was 4.9 (4-31) and my Renin was <0.15 (1.31-3.95) The results I got back today are the following Aldo (post dex suppression) 3.3 (1-16) and my Renin was 7.59 (0.15-2.33) the normals are a little different because this time they had me laying down for 15 minutes prior to the blood draw because they were also taking blood for plasma free metanephrines. The difference medication wise is that in November I was on 50mg of Cozaar and 20mg of Nadolol and now I am on 100mg Cozaar and 40mg of Coreg CR. The urine NA was normal, Cl was low 74 (110-250), and we don't have the Potassium back yet. I am just a little confused on how my renin can go from being extremely low <0.15 to being so high of 7.59. Is Cozaar affecting the results and just confusing the issue? Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2010 Report Share Posted February 9, 2010 You were on an excellent DASH diet. Unless you had been on diuretics and stopped. Clarence E. Grim, BS, MS, MD Specializing in Primary Aldosteronism, Difficult High Blood Pressure and recent evolutionary forces on high blood pressure in populations today. On Monday, February 08, 2010, at 08:11PM, <cowdoc@...> wrote: > I am sorry about the unclear information sodium concentration was 34 MEQ/L and the sodium excretion was 74 MEQ/24 HRS. Total urine volume for the 24 HRS was 2170 ml. Dana Sent from my Verizon Wireless BlackBerry From: lowerbp2 <lowerbp2mac> Date: Mon, 08 Feb 2010 20:02:43 -0600 <hyperaldosteronism > Subject: Re: Blood Results Now I need to know if this is the Na concentration/L or the total amount in the 24 hr urine. If the total amount then it is lower than most folks. If a concentration multiply this by your urine volume in the collection to get amount excreted (and eaten). Use the following notation when talking about Na in urine [Na] = sodium concentration as in mM/L or mEq/L ENA = sodium excreted. Should be E with the Na as a subscript but can't seem to do this in my email. UV = urine volume ENa = [Na] x UV Clarence E. Grim, BS, MS, MD Specializing in Primary Aldosteronism, Difficult High Blood Pressure and recent evolutionary forces on high blood pressure in populations today. On Monday, February 08, 2010, at 06:43PM, <cowdocsbcglobal (DOT) net> wrote: > Sorry about the normal comment NA was 74 (40-220) the problem is I don't have a NA value from the first time. Dana Sent from my Verizon Wireless BlackBerry From: Clarence Grim <lowerbp2mac> Date: Mon, 08 Feb 2010 18:36:36 -0600 <hyperaldosteronism > Subject: Re: Blood Results yes Cozaar can increase renin. The post dex aldo means you don't have GRA. Good news. Never give me a reading of "normal". I need the numbers. If you salt intake was much lower that the first measurement then that will also increase renin. But it would have to be a lot lower so need to know that the Na (and K) was. CE Grim MD On Feb 8, 2010, at 6:15 PM, Dana wrote: Dr. Grim now I am totally confused. I got my blood work back today but have not talked to the endo docs yet. In Mid-November my Aldo was 4.9 (4-31) and my Renin was <0.15 (1.31-3.95) The results I got back today are the following Aldo (post dex suppression) 3.3 (1-16) and my Renin was 7.59 (0.15-2.33) the normals are a little different because this time they had me laying down for 15 minutes prior to the blood draw because they were also taking blood for plasma free metanephrines. The difference medication wise is that in November I was on 50mg of Cozaar and 20mg of Nadolol and now I am on 100mg Cozaar and 40mg of Coreg CR. The urine NA was normal, Cl was low 74 (110-250), and we don't have the Potassium back yet. I am just a little confused on how my renin can go from being extremely low <0.15 to being so high of 7.59. Is Cozaar affecting the results and just confusing the issue? Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 14, 2011 Report Share Posted December 14, 2011 Dear all could you look at my daughters blood results please serum vitamin B12 274 ng/L range (210- 9120 serum ferritin 37 ug/L range (9-292) Thyroid Function test serum ft4 level 18.3 pmol/L range (9.0 21.0) Serum TSH level 2.51 mu/L range (0.35- 5.50) Thank you Janet Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 15, 2011 Report Share Posted December 15, 2011 Not a good Christmas present to have Janet. Your daughter's vitamin B12 of 274 is right at the bottom of the range, and this is one test that should be right at the top of the reference range for it to be normal. I see you added a '0' at the end of 912 - but 912 will be the top of the range. She should be showing a level above 800. This is so low I would question her GP as to the possibility of getting a course of B12 injections. Her serum ferritin too is too low and should be above 90 in the reference range. She needs at least 200mgs Ferrous Fumerate or Ferrous Glutamate twice daily and foods that are high in iron. A free T4 level of 18 is quite high for somebody who is not taking any thyroid hormone replacement. For those not on treatment, free T4 should be just over the middle of the reference range. It could be that the thyroxine her thyroid is secreting is not converting to the active thyroid hormone T3, but we need to see her free T3 result to see whether that result is showing too low. Certainly, her TSH should be around 1.0 to be normal, and if she lived in other countries in Europe, i.e. Sweden, Germany, Belgium, a TSH reading of 2.5 would result in thyroid hormone replacement being started. Has the GP made any suggestions after seeing these results? Luv - Sheila Dear all could you look at my daughters blood results please serum vitamin B12 274 ng/L range (210- 9120 serum ferritin 37 ug/L range (9-292) Thyroid Function test serum ft4 level 18.3 pmol/L range (9.0 21.0) Serum TSH level 2.51 mu/L range (0.35- 5.50) Thank you Janet Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 16, 2011 Report Share Posted December 16, 2011 > > Not a good Christmas present to have Janet. Your daughter's vitamin B12 of > 274 is right at the bottom of the range, and this is one test that should be > > > Has the GP made any suggestions after seeing these results? > > Luv - Sheila > Hi Sheila >Thanks for your reply, i went with my daughter who has special needs to the doctors last night to discuss B12 and iron levels, and i was told the results were within normal ranges which is what i expected then went on to say if my daughter was eating a healthy diet, that there shouldn't be any problems. I went on to explain that my daughter will not eat any red meat not a lot of veg, or fruit...... Waste of time i think of even bothering to go and to speak to GP I am very concerned, what should i do now?? Janet Quote Link to comment Share on other sites More sharing options...
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